SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 115
ALA A 166
ILE A 137
ILE A 153
ALA A 154
 None
 0.93A 2bxcA-4gvrA:
undetectable		 2bxcA-4gvrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 227
SER A 228
SER A 181
GLN A 179
 None
 1.06A 2cmlB-4gvrA:
undetectable		 2cmlB-4gvrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 227
SER A 228
SER A 181
GLN A 179
 None
 1.06A 2cmlD-4gvrA:
undetectable		 2cmlD-4gvrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 7 THR A  53
ILE A  50
GLY A  49
ILE A 211
 None
 0.78A 2y7wC-4gvrA:
undetectable		 2y7wC-4gvrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 114
GLY A  96
GLY A 110
ILE A 137
 None
 0.64A 4eatA-4gvrA:
undetectable		 4eatA-4gvrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 4 ASN A  31
GLY A  32
ASP A 130
ASP A 160
 None
 1.40A 4n49A-4gvrA:
undetectable		 4n49A-4gvrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  91
PRO A 111
ALA A   8
ILE A   7
LEU A  60
 None
 1.16A 5bw4B-4gvrA:
undetectable		 5bw4B-4gvrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 108
ASP A  37
ILE A  34
TYR A 104
 None
 1.05A 5iwuA-4gvrA:
undetectable		 5iwuA-4gvrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 11 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
 None
 1.06A 5x6yA-4gvrA:
undetectable		 5x6yA-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
 None
 1.04A 5x6yB-4gvrA:
undetectable		 5x6yB-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 11 VAL A 235
GLY A 207
GLU A  80
ALA A 188
LEU A 237
 None
 1.13A 5x6yC-4gvrA:
undetectable		 5x6yC-4gvrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		4 / 7 GLY A  39
SER A  45
GLY A  44
VAL A  42
 None
 0.76A 6ekzA-4gvrA:
undetectable		 6ekzA-4gvrA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A  84
THR A  82
LEU A   2
LEU A  60
GLY A  59
 None
 1.49A 6f3nC-4gvrA:
undetectable		 6f3nC-4gvrA:
22.48