SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		4 / 8 GLY A  15
ASN A  90
GLY A  14
VAL A 186
 None
NAP  A 301 (-3.4A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.8A)
 0.92A 1dbbH-4gvxA:
undetectable
1dbbL-4gvxA:
undetectable		 1dbbH-4gvxA:
22.51
1dbbL-4gvxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 12 ILE A  23
ALA A  22
GLY A  18
ILE A 224
GLY A  14
 None
None
NAP  A 301 (-3.5A)
None
NAP  A 301 (-3.2A)
 0.83A 2qe6A-4gvxA:
6.1		 2qe6A-4gvxA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 12 ILE A  23
ALA A  22
GLY A  18
ILE A 224
GLY A  14
 None
None
NAP  A 301 (-3.5A)
None
NAP  A 301 (-3.2A)
 0.93A 2qe6B-4gvxA:
5.9		 2qe6B-4gvxA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		3 / 3 ARG A  39
GLU A  63
SER A  24
 NAP  A 301 (-3.6A)
NAP  A 301 (-3.3A)
None
 0.91A 2xctD-4gvxA:
3.5		 2xctD-4gvxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		4 / 6 VAL A 107
GLN A  65
GLY A  92
LEU A 190
 None
NAP  A 301 ( 4.5A)
NAP  A 301 ( 3.7A)
NAP  A 301 (-3.7A)
 0.97A 3bjwE-4gvxA:
undetectable		 3bjwE-4gvxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 TYR A 117
SER A 139
ASN A 137
GLY A 158
ALA A 159
 None
 1.23A 4fh2A-4gvxA:
undetectable		 4fh2A-4gvxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 12 GLY A  20
GLY A  15
GLY A  14
ALA A 225
VAL A 186
 None
None
NAP  A 301 (-3.2A)
None
NAP  A 301 (-3.8A)
 0.88A 4htfA-4gvxA:
7.4		 4htfA-4gvxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 11 GLY A  14
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 NAP  A 301 (-3.2A)
None
None
None
None
 1.20A 4j4vA-4gvxA:
undetectable		 4j4vA-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 11 GLY A  15
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 None
 1.44A 4j4vA-4gvxA:
undetectable		 4j4vA-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 GLY A  14
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 NAP  A 301 (-3.2A)
None
None
None
None
 1.18A 4j4vB-4gvxA:
undetectable		 4j4vB-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 11 GLY A  14
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 NAP  A 301 (-3.2A)
None
None
None
None
 1.22A 4j4vD-4gvxA:
undetectable
4j4vE-4gvxA:
undetectable		 4j4vD-4gvxA:
21.92
4j4vE-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 11 GLY A  15
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 None
 1.38A 4j4vD-4gvxA:
undetectable
4j4vE-4gvxA:
undetectable		 4j4vD-4gvxA:
21.92
4j4vE-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 GLY A  14
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 NAP  A 301 (-3.2A)
None
None
None
None
 1.23A 4j4vA-4gvxA:
0.0
4j4vE-4gvxA:
0.0		 4j4vA-4gvxA:
21.92
4j4vE-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		5 / 10 GLY A  15
ALA A 228
VAL A  12
PRO A  42
PHE A  46
 None
 1.44A 4j4vA-4gvxA:
0.0
4j4vE-4gvxA:
0.0		 4j4vA-4gvxA:
21.92
4j4vE-4gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Burkholderia
multivorans) 		4 / 8 ALA A  73
THR A  77
THR A  80
ALA A  57
 None
 0.93A 5x2tI-4gvxA:
undetectable
5x2tJ-4gvxA:
undetectable
5x2tK-4gvxA:
undetectable
5x2tL-4gvxA:
undetectable		 5x2tI-4gvxA:
22.31
5x2tJ-4gvxA:
18.99
5x2tK-4gvxA:
22.31
5x2tL-4gvxA:
18.99