SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 11 GLY A 585
HIS A 560
GLY A 620
LEU A 541
ILE A 540
 None
 0.96A 1jzsA-4gw9A:
undetectable		 1jzsA-4gw9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 9 GLY A 178
GLU A 174
GLY A 176
ASP A 481
ARG A 440
 None
 1.09A 1mxdA-4gw9A:
undetectable		 1mxdA-4gw9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 391
ILE A 385
TRP A 388
 None
 1.07A 1nodB-4gw9A:
undetectable		 1nodB-4gw9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 209
ILE A 253
SER A 468
LEU A 218
LEU A 258
 None
BLA  A 900 (-4.2A)
BLA  A 900 (-3.9A)
None
None
 1.17A 1s19A-4gw9A:
undetectable		 1s19A-4gw9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 547
LEU A 561
ILE A 540
GLY A 566
LEU A 594
 None
 1.01A 2lbdA-4gw9A:
undetectable		 2lbdA-4gw9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 389
GLY A 430
ALA A 423
ALA A 422
VAL A 421
 None
 0.94A 2oc8A-4gw9A:
undetectable		 2oc8A-4gw9A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 8 PHE A 324
THR A 493
ILE A 494
THR A 497
 None
 0.98A 3bpxA-4gw9A:
0.8
3bpxB-4gw9A:
undetectable		 3bpxA-4gw9A:
14.86
3bpxB-4gw9A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 5 ALA A  50
LEU A 247
GLY A  35
THR A 103
 None
 0.97A 3dl9A-4gw9A:
undetectable		 3dl9A-4gw9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 4 ILE A 494
PHE A 324
ILE A 353
THR A 497
 None
 1.17A 3ia4A-4gw9A:
undetectable		 3ia4A-4gw9A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 411
LEU A 405
SER A 402
THR A 414
 None
 1.06A 4d7bB-4gw9A:
undetectable		 4d7bB-4gw9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 458
ASN A  19
CYH A  20
GLU A  23
 None
None
BLA  A 900 (-1.6A)
None
 1.00A 4gkhD-4gw9A:
undetectable		 4gkhD-4gw9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 411
LEU A 405
SER A 402
THR A 414
 None
 1.04A 4i89A-4gw9A:
undetectable		 4i89A-4gw9A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 8 LEU A 271
VAL A 281
LEU A 313
LEU A 147
 None
 0.98A 4l1xA-4gw9A:
undetectable		 4l1xA-4gw9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		3 / 3 ARG A 343
ASP A 341
TRP A 342
 None
 0.95A 4xdqA-4gw9A:
undetectable		 4xdqA-4gw9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 422
ASP A 406
GLY A 419
SER A 418
THR A 414
 None
 1.19A 5hfjE-4gw9A:
undetectable		 5hfjE-4gw9A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 10 ILE A  47
LEU A  64
ILE A 118
LEU A 240
LEU A  58
 None
 1.16A 5ienB-4gw9A:
undetectable		 5ienB-4gw9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 411
LEU A 405
SER A 402
THR A 414
 None
 1.04A 5l4iA-4gw9A:
undetectable		 5l4iA-4gw9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 411
LEU A 405
SER A 402
THR A 414
 None
 1.02A 5l4iB-4gw9A:
undetectable		 5l4iB-4gw9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4gw9 BACTERIOPHYTOCHROME
(Rhodopseudomonas
palustris) 		5 / 11 LEU A 157
LEU A 302
ARG A 142
GLU A 139
ALA A 137
 None
 1.00A 5o96G-4gw9A:
undetectable		 5o96G-4gw9A:
17.88