SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3
(Sinorhizobium
meliloti) 		4 / 6 ALA A   8
LEU A   7
ILE A  94
SER A  92
 None
 1.06A 1sbrA-4gwbA:
undetectable
1sbrB-4gwbA:
undetectable		 1sbrA-4gwbA:
21.96
1sbrB-4gwbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3
(Sinorhizobium
meliloti) 		3 / 5 GLY A  14
GLY A  10
GLU A  50
 None
 0.49A 4z2eA-4gwbA:
2.0
4z2eD-4gwbA:
undetectable		 4z2eA-4gwbA:
14.97
4z2eD-4gwbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3
(Sinorhizobium
meliloti) 		4 / 8 SER A  92
ALA A  93
HIS A  74
LEU A  67
 None
 1.21A 5dzkF-4gwbA:
undetectable
5dzkT-4gwbA:
undetectable		 5dzkF-4gwbA:
22.57
5dzkT-4gwbA:
2.99