SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 8 ILE A  64
ASN A 130
GLY A 159
LEU A 252
 None
 0.85A 1dzmA-4gwnA:
undetectable		 1dzmA-4gwnA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 GLY A 294
PRO A 292
ASP A 315
SER A 348
 None
 0.88A 1gxsA-4gwnA:
undetectable
1gxsB-4gwnA:
undetectable		 1gxsA-4gwnA:
21.14
1gxsB-4gwnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 ILE A 434
TRP A 432
LEU A 467
GLY A 446
PHE A 440
 None
 1.29A 1i00B-4gwnA:
undetectable		 1i00B-4gwnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 THR A 149
HIS A 152
GLU A 153
HIS A 156
TYR A 211
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
None
 0.41A 1j36A-4gwnA:
3.8		 1j36A-4gwnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 THR A 149
HIS A 152
GLU A 153
HIS A 156
TYR A 211
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
None
 0.41A 1j36B-4gwnA:
3.7		 1j36B-4gwnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 PHE A 545
TYR A 454
PRO A 452
 NAG  A 713 (-3.5A)
MAN  A 717 (-3.9A)
NAG  A 713 (-4.6A)
 1.13A 1mcnA-4gwnA:
undetectable
1mcnB-4gwnA:
undetectable
1mcnP-4gwnA:
undetectable		 1mcnA-4gwnA:
17.59
1mcnB-4gwnA:
17.59
1mcnP-4gwnA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.25A 1os2A-4gwnA:
9.7		 1os2A-4gwnA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.28A 1os2D-4gwnA:
9.7		 1os2D-4gwnA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 10 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.48A 1r55A-4gwnA:
6.4		 1r55A-4gwnA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 11 LEU A 138
ALA A 157
VAL A 118
LEU A  79
MET A 209
 None
 1.10A 1rlbF-4gwnA:
undetectable		 1rlbF-4gwnA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.34A 1uttA-4gwnA:
9.6		 1uttA-4gwnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.27A 1utzA-4gwnA:
9.5		 1utzA-4gwnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.30A 1utzB-4gwnA:
9.6		 1utzB-4gwnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.29A 1y93A-4gwnA:
9.2		 1y93A-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 SER A 242
ASP A 204
SER A 244
GLN A 151
 None
 1.08A 2cmlA-4gwnA:
undetectable		 2cmlA-4gwnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.71A 2einN-4gwnA:
undetectable		 2einN-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.29A 2hu6A-4gwnA:
9.3		 2hu6A-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 ASP A 353
SER A 316
LEU A 412
GLY A 413
 None
 1.21A 2j2pA-4gwnA:
undetectable
2j2pB-4gwnA:
undetectable		 2j2pA-4gwnA:
17.56
2j2pB-4gwnA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 8 LEU A 568
LEU A 501
ASP A 503
ASP A 572
 None
 1.06A 2j2pA-4gwnA:
undetectable
2j2pB-4gwnA:
undetectable		 2j2pA-4gwnA:
17.56
2j2pB-4gwnA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.41A 2jihA-4gwnA:
7.2		 2jihA-4gwnA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 8 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.39A 2jihB-4gwnA:
6.6		 2jihB-4gwnA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.18A 2ow9A-4gwnA:
9.4		 2ow9A-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.23A 2ow9B-4gwnA:
9.5		 2ow9B-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.20A 2ozrC-4gwnA:
9.5		 2ozrC-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.22A 2ozrD-4gwnA:
9.5		 2ozrD-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.38A 2ozrE-4gwnA:
9.6		 2ozrE-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 152
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.34A 2ozrF-4gwnA:
9.5		 2ozrF-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 11 LEU A 448
ILE A 441
ALA A 473
ARG A 511
LEU A 501
 None
 1.28A 2v0mA-4gwnA:
undetectable		 2v0mA-4gwnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.77A 3ablA-4gwnA:
undetectable		 3ablA-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.70A 3bvdA-4gwnA:
undetectable		 3bvdA-4gwnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 8 GLY A 413
GLY A 414
ILE A 380
SER A 350
SER A 411
 None
 1.14A 3d41A-4gwnA:
undetectable		 3d41A-4gwnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.34A 3hy7A-4gwnA:
7.8		 3hy7A-4gwnA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
 None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.36A 3hy7B-4gwnA:
4.2		 3hy7B-4gwnA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 12 SER A 316
LEU A 345
SER A 416
ILE A 380
SER A 348
 None
 1.39A 3iltB-4gwnA:
undetectable
3iltE-4gwnA:
undetectable		 3iltB-4gwnA:
19.49
3iltE-4gwnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 10 ILE A 380
SER A 348
SER A 316
LEU A 345
SER A 416
 None
 1.30A 3iltB-4gwnA:
undetectable
3iltE-4gwnA:
undetectable		 3iltB-4gwnA:
19.49
3iltE-4gwnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.24A 3kecA-4gwnA:
9.6		 3kecA-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 152
GLU A 153
HIS A 156
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
 0.13A 3kecB-4gwnA:
9.6		 3kecB-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.28A 3likA-4gwnA:
9.3		 3likA-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.29A 3lilA-4gwnA:
9.4		 3lilA-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.32A 3ljgA-4gwnA:
9.5		 3ljgA-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.27A 3lkaA-4gwnA:
9.3		 3lkaA-4gwnA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 10 PHE A 437
ILE A 434
ILE A 475
LEU A 467
HIS A 565
 None
 1.28A 3o1cA-4gwnA:
undetectable		 3o1cA-4gwnA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 ASN A 421
ASP A 418
GLU A 296
SER A 264
 None
NA  A 702 (-2.3A)
None
None
 0.99A 3p2kC-4gwnA:
undetectable		 3p2kC-4gwnA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.75A 3s33A-4gwnA:
undetectable		 3s33A-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.70A 3s38A-4gwnA:
undetectable		 3s38A-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.76A 3s39A-4gwnA:
undetectable		 3s39A-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.76A 3s3aA-4gwnA:
undetectable		 3s3aA-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.79A 3s3bA-4gwnA:
undetectable		 3s3bA-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.77A 3s3cA-4gwnA:
undetectable		 3s3cA-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.75A 3s3dA-4gwnA:
undetectable		 3s3dA-4gwnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.74A 3wg7A-4gwnA:
undetectable		 3wg7A-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.73A 3x2qN-4gwnA:
undetectable		 3x2qN-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.22A 4a7bA-4gwnA:
9.5		 4a7bA-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 SER A 456
TYR A 459
PHE A 461
PHE A 477
 None
 1.43A 4awuA-4gwnA:
undetectable		 4awuA-4gwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 MET A 302
ASP A 578
PHE A 437
 None
 1.00A 4xeyA-4gwnA:
undetectable		 4xeyA-4gwnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 MET A 302
ASP A 578
PHE A 437
 None
 0.98A 4xeyB-4gwnA:
undetectable		 4xeyB-4gwnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 7 ARG A 293
GLY A 349
SER A 411
LEU A 412
 None
 1.10A 5bphB-4gwnA:
undetectable		 5bphB-4gwnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 6 ARG A 293
GLY A 349
SER A 411
LEU A 412
 None
 1.06A 5bphD-4gwnA:
undetectable		 5bphD-4gwnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 ALA A 325
THR A 324
ALA A 323
ALA A 283
ASP A 315
 None
 1.10A 5l5zK-4gwnA:
undetectable
5l5zL-4gwnA:
undetectable		 5l5zK-4gwnA:
16.67
5l5zL-4gwnA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 9 ALA A 325
THR A 324
ALA A 323
ALA A 283
ASP A 315
 None
 1.11A 5l5zY-4gwnA:
undetectable
5l5zZ-4gwnA:
undetectable		 5l5zY-4gwnA:
16.67
5l5zZ-4gwnA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.29A 5n5jA-4gwnA:
9.3		 5n5jA-4gwnA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.25A 5n5kA-4gwnA:
9.2		 5n5kA-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.70A 5x1bN-4gwnA:
undetectable		 5x1bN-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.67A 5x1fN-4gwnA:
undetectable		 5x1fN-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.78A 5z84N-4gwnA:
undetectable		 5z84N-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.77A 5z85N-4gwnA:
undetectable		 5z85N-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.78A 5z86N-4gwnA:
undetectable		 5z86N-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.74A 5zcoN-4gwnA:
undetectable		 5zcoN-4gwnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		4 / 5 LEU A 252
TYR A 253
ILE A 147
GLY A 129
 None
 0.85A 6hd6A-4gwnA:
undetectable		 6hd6A-4gwnA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.73A 6hu9a-4gwnA:
undetectable		 6hu9a-4gwnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		3 / 3 HIS A 162
HIS A 156
HIS A 152
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.74A 6hu9m-4gwnA:
undetectable		 6hu9m-4gwnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 10 ASP A 353
GLY A 349
ASP A 281
THR A 324
SER A 318
 None
 1.31A 6mn1A-4gwnA:
undetectable		 6mn1A-4gwnA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens) 		5 / 10 ASP A 353
GLY A 349
ASP A 281
THR A 324
SER A 318
 None
 1.29A 6mn1B-4gwnA:
undetectable		 6mn1B-4gwnA:
10.53