SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens) 		4 / 7 GLU A 164
THR A 223
VAL A 224
ALA A 219
 None
 0.87A 1fo4B-4gwrA:
undetectable		 1fo4B-4gwrA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens) 		4 / 5 VAL A 183
VAL A 174
ASP A 171
SER A 169
 None
 1.25A 2x45A-4gwrA:
undetectable		 2x45A-4gwrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens) 		4 / 5 VAL A 183
VAL A 174
ASP A 171
SER A 169
 None
 1.14A 2x45C-4gwrA:
undetectable		 2x45C-4gwrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens) 		4 / 7 LEU A 228
VAL A 162
TYR A 186
GLU A 164
 None
 1.15A 5umwA-4gwrA:
undetectable
5umwF-4gwrA:
undetectable		 5umwA-4gwrA:
23.44
5umwF-4gwrA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens) 		5 / 12 VAL A 220
VAL A 162
ALA A 204
PHE A 243
LEU A 175
 None
 1.38A 6a7pB-4gwrA:
undetectable		 6a7pB-4gwrA:
11.49