SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 4 HIS A 479
LEU A 149
LEU A 145
LEU A 247
 None
 1.08A 1a4lD-4gx0A:
undetectable		 1a4lD-4gx0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 398
HIS A 359
PHE A 355
LEU A 353
ALA A 407
 None
ZN  A 606 (-3.5A)
None
None
None
 1.06A 1bzfA-4gx0A:
2.9		 1bzfA-4gx0A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.12A 1gtnB-4gx0A:
undetectable
1gtnC-4gx0A:
undetectable		 1gtnB-4gx0A:
8.70
1gtnC-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.13A 1gtnB-4gx0A:
undetectable
1gtnC-4gx0A:
undetectable		 1gtnB-4gx0A:
8.70
1gtnC-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.16A 1gtnH-4gx0A:
undetectable
1gtnI-4gx0A:
undetectable		 1gtnH-4gx0A:
8.70
1gtnI-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.18A 1gtnH-4gx0A:
undetectable
1gtnI-4gx0A:
undetectable		 1gtnH-4gx0A:
8.70
1gtnI-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.11A 1gtnM-4gx0A:
undetectable
1gtnN-4gx0A:
undetectable		 1gtnM-4gx0A:
8.70
1gtnN-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 None
ZN  A 606 (-3.5A)
None
None
None
 1.31A 1gtnO-4gx0A:
undetectable
1gtnP-4gx0A:
undetectable		 1gtnO-4gx0A:
8.70
1gtnP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 None
ZN  A 606 (-3.5A)
None
None
None
 1.26A 1gtnQ-4gx0A:
undetectable
1gtnR-4gx0A:
undetectable		 1gtnQ-4gx0A:
8.70
1gtnR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.00A 1sa1A-4gx0A:
5.5
1sa1B-4gx0A:
5.2		 1sa1A-4gx0A:
23.78
1sa1B-4gx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 231
CYH A 212
LEU A 213
ALA A 239
ALA A 225
 None
 1.00A 1sa1C-4gx0A:
5.5
1sa1D-4gx0A:
undetectable		 1sa1C-4gx0A:
23.78
1sa1D-4gx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.14A 1utdT-4gx0A:
undetectable
1utdU-4gx0A:
undetectable		 1utdT-4gx0A:
8.70
1utdU-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 THR A 142
PRO A 140
THR A 144
 None
 0.78A 209dC-4gx0A:
undetectable		 209dC-4gx0A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 PHE A 136
VAL A 178
GLU A 124
LEU A 125
ARG A 192
 None
 1.29A 2bxfB-4gx0A:
3.1		 2bxfB-4gx0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 GLY A 363
ALA A 367
ALA A 366
HIS A 391
 None
None
None
ZN  A 606 (-3.3A)
 0.69A 2ha4B-4gx0A:
undetectable		 2ha4B-4gx0A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 TYR A 119
VAL A 178
TYR A 163
ILE A 123
 None
 1.22A 2xz5B-4gx0A:
undetectable
2xz5E-4gx0A:
undetectable		 2xz5B-4gx0A:
16.79
2xz5E-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.21A 2xz5A-4gx0A:
undetectable
2xz5C-4gx0A:
undetectable		 2xz5A-4gx0A:
16.79
2xz5C-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.19A 2xz5C-4gx0A:
undetectable
2xz5D-4gx0A:
undetectable		 2xz5C-4gx0A:
16.79
2xz5D-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.20A 2xz5D-4gx0A:
undetectable
2xz5E-4gx0A:
undetectable		 2xz5D-4gx0A:
16.79
2xz5E-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 193
ALA A 196
VAL A 178
THR A 214
ILE A 223
 None
 1.10A 3czhA-4gx0A:
undetectable		 3czhA-4gx0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A 394
ILE A 409
ASP A 410
ALA A 412
ILE A 354
 None
 1.14A 3ddyA-4gx0A:
undetectable		 3ddyA-4gx0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
PO4  A 608 (-3.8A)
 0.96A 3ekxB-4gx0A:
undetectable		 3ekxB-4gx0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 368
ILE A 356
GLY A 256
ILE A 257
THR A 248
 None
 1.09A 3el5A-4gx0A:
undetectable		 3el5A-4gx0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 ARG A 253
VAL A 375
THR A 260
 None
 0.81A 3ndtA-4gx0A:
undetectable		 3ndtA-4gx0A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
PO4  A 608 (-3.8A)
 0.97A 3ndwB-4gx0A:
undetectable		 3ndwB-4gx0A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 606 (-3.3A)
ZN  A 606 (-3.5A)
 1.22A 3o1cA-4gx0A:
undetectable		 3o1cA-4gx0A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 606 (-3.3A)
ZN  A 606 (-3.5A)
 1.22A 3o1xA-4gx0A:
undetectable		 3o1xA-4gx0A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
PO4  A 608 (-3.8A)
 0.93A 3oxcB-4gx0A:
undetectable		 3oxcB-4gx0A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 PHE A 377
ILE A 416
LEU A 379
HIS A 391
HIS A 359
 None
None
None
ZN  A 606 (-3.3A)
ZN  A 606 (-3.5A)
 1.24A 3qgzA-4gx0A:
undetectable		 3qgzA-4gx0A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 TYR A 119
VAL A 178
TYR A 163
VAL A 187
ILE A 123
 None
 1.49A 4aftA-4gx0A:
0.0
4aftB-4gx0A:
0.0		 4aftA-4gx0A:
16.79
4aftB-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 VAL A 187
ILE A 123
TYR A 119
VAL A 178
TYR A 163
 None
 1.39A 4aftA-4gx0A:
0.0
4aftE-4gx0A:
0.0		 4aftA-4gx0A:
16.79
4aftE-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 ARG A 253
ARG A 249
ILE A 257
 None
 0.84A 4b7qA-4gx0A:
undetectable		 4b7qA-4gx0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 ARG A 253
ARG A 249
ILE A 257
 None
 0.82A 4b7qC-4gx0A:
undetectable		 4b7qC-4gx0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 TYR A 119
VAL A 178
TYR A 163
ILE A 123
 None
 1.29A 4bqtC-4gx0A:
undetectable
4bqtD-4gx0A:
undetectable		 4bqtC-4gx0A:
16.79
4bqtD-4gx0A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 ALA A 445
ILE A 362
LEU A 251
ASN A 446
 None
PO4  A 608 (-3.8A)
None
None
 1.15A 4g19A-4gx0A:
undetectable		 4g19A-4gx0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 225
ALA A 201
LEU A 211
LEU A 236
ALA A 241
 None
 1.08A 4k6iA-4gx0A:
undetectable		 4k6iA-4gx0A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 259
ILE A 416
LEU A 404
ILE A 439
THR A 260
 None
 1.12A 4km0B-4gx0A:
undetectable		 4km0B-4gx0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 259
ILE A 416
LEU A 404
ILE A 439
THR A 260
 None
 1.10A 4km2A-4gx0A:
undetectable		 4km2A-4gx0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 GLY A 358
ASP A 381
PHE A 377
ILE A 356
ALA A 366
 None
 1.04A 4wh5A-4gx0A:
undetectable		 4wh5A-4gx0A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eeuF-4gx0A:
undetectable
5eeuG-4gx0A:
undetectable		 5eeuF-4gx0A:
8.70
5eeuG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.15A 5eeuF-4gx0A:
undetectable
5eeuG-4gx0A:
undetectable		 5eeuF-4gx0A:
8.70
5eeuG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.10A 5eeuI-4gx0A:
undetectable
5eeuJ-4gx0A:
undetectable		 5eeuI-4gx0A:
8.70
5eeuJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.14A 5eeuI-4gx0A:
undetectable
5eeuJ-4gx0A:
undetectable		 5eeuI-4gx0A:
8.70
5eeuJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5eeuO-4gx0A:
undetectable
5eeuP-4gx0A:
undetectable		 5eeuO-4gx0A:
8.70
5eeuP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.14A 5eeuQ-4gx0A:
undetectable
5eeuR-4gx0A:
undetectable		 5eeuQ-4gx0A:
8.70
5eeuR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 606 (-3.5A)
None
None
None
None
 1.14A 5eeuQ-4gx0A:
undetectable
5eeuR-4gx0A:
undetectable		 5eeuQ-4gx0A:
8.70
5eeuR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eevF-4gx0A:
undetectable
5eevG-4gx0A:
undetectable		 5eevF-4gx0A:
8.70
5eevG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.16A 5eevF-4gx0A:
undetectable
5eevG-4gx0A:
undetectable		 5eevF-4gx0A:
8.70
5eevG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.10A 5eevI-4gx0A:
undetectable
5eevJ-4gx0A:
undetectable		 5eevI-4gx0A:
8.70
5eevJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.14A 5eevI-4gx0A:
undetectable
5eevJ-4gx0A:
undetectable		 5eevI-4gx0A:
8.70
5eevJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5eevO-4gx0A:
undetectable
5eevP-4gx0A:
undetectable		 5eevO-4gx0A:
8.70
5eevP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.13A 5eevQ-4gx0A:
undetectable
5eevR-4gx0A:
undetectable		 5eevQ-4gx0A:
8.70
5eevR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 606 (-3.5A)
None
None
None
None
 1.14A 5eevQ-4gx0A:
undetectable
5eevR-4gx0A:
undetectable		 5eevQ-4gx0A:
8.70
5eevR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eewF-4gx0A:
undetectable
5eewG-4gx0A:
undetectable		 5eewF-4gx0A:
8.70
5eewG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.15A 5eewF-4gx0A:
undetectable
5eewG-4gx0A:
undetectable		 5eewF-4gx0A:
8.70
5eewG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.09A 5eewI-4gx0A:
undetectable
5eewJ-4gx0A:
undetectable		 5eewI-4gx0A:
8.70
5eewJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.14A 5eewI-4gx0A:
undetectable
5eewJ-4gx0A:
undetectable		 5eewI-4gx0A:
8.70
5eewJ-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.11A 5eewO-4gx0A:
undetectable
5eewP-4gx0A:
undetectable		 5eewO-4gx0A:
8.70
5eewP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.13A 5eewQ-4gx0A:
undetectable
5eewR-4gx0A:
undetectable		 5eewQ-4gx0A:
8.70
5eewR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 359
ALA A 366
THR A 418
ILE A 416
ALA A 365
 ZN  A 606 (-3.5A)
None
None
None
None
 1.14A 5eewQ-4gx0A:
undetectable
5eewR-4gx0A:
undetectable		 5eewQ-4gx0A:
8.70
5eewR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eexF-4gx0A:
undetectable
5eexG-4gx0A:
undetectable		 5eexF-4gx0A:
8.70
5eexG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.15A 5eexF-4gx0A:
undetectable
5eexG-4gx0A:
undetectable		 5eexF-4gx0A:
8.70
5eexG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5eexO-4gx0A:
undetectable
5eexP-4gx0A:
undetectable		 5eexO-4gx0A:
8.70
5eexP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eeyF-4gx0A:
undetectable
5eeyG-4gx0A:
undetectable		 5eeyF-4gx0A:
8.70
5eeyG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.16A 5eeyF-4gx0A:
undetectable
5eeyG-4gx0A:
undetectable		 5eeyF-4gx0A:
8.70
5eeyG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.11A 5eeyO-4gx0A:
undetectable
5eeyP-4gx0A:
undetectable		 5eeyO-4gx0A:
8.70
5eeyP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5eezF-4gx0A:
undetectable
5eezG-4gx0A:
undetectable		 5eezF-4gx0A:
8.70
5eezG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.15A 5eezF-4gx0A:
undetectable
5eezG-4gx0A:
undetectable		 5eezF-4gx0A:
8.70
5eezG-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5eezO-4gx0A:
undetectable
5eezP-4gx0A:
undetectable		 5eezO-4gx0A:
8.70
5eezP-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5ef0F-4gx0A:
undetectable
5ef0G-4gx0A:
undetectable		 5ef0F-4gx0A:
8.70
5ef0G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.16A 5ef0F-4gx0A:
undetectable
5ef0G-4gx0A:
undetectable		 5ef0F-4gx0A:
8.70
5ef0G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.11A 5ef0O-4gx0A:
undetectable
5ef0P-4gx0A:
undetectable		 5ef0O-4gx0A:
8.70
5ef0P-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5ef1F-4gx0A:
undetectable
5ef1G-4gx0A:
undetectable		 5ef1F-4gx0A:
8.70
5ef1G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.15A 5ef1F-4gx0A:
undetectable
5ef1G-4gx0A:
undetectable		 5ef1F-4gx0A:
8.70
5ef1G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5ef1O-4gx0A:
undetectable
5ef1P-4gx0A:
undetectable		 5ef1O-4gx0A:
8.70
5ef1P-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5ef2F-4gx0A:
undetectable
5ef2G-4gx0A:
undetectable		 5ef2F-4gx0A:
8.70
5ef2G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.16A 5ef2F-4gx0A:
undetectable
5ef2G-4gx0A:
undetectable		 5ef2F-4gx0A:
8.70
5ef2G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5ef2O-4gx0A:
undetectable
5ef2P-4gx0A:
undetectable		 5ef2O-4gx0A:
8.70
5ef2P-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
GLY A 358
ALA A 366
THR A 418
ILE A 356
 None
 1.11A 5ef3F-4gx0A:
undetectable
5ef3G-4gx0A:
undetectable		 5ef3F-4gx0A:
8.70
5ef3G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ALA A 365
HIS A 359
ALA A 366
THR A 418
ILE A 416
 None
ZN  A 606 (-3.5A)
None
None
None
 1.16A 5ef3F-4gx0A:
undetectable
5ef3G-4gx0A:
undetectable		 5ef3F-4gx0A:
8.70
5ef3G-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 GLY A 358
ALA A 366
THR A 418
ILE A 356
ALA A 365
 None
 1.12A 5ef3O-4gx0A:
undetectable
5ef3P-4gx0A:
undetectable		 5ef3O-4gx0A:
8.70
5ef3P-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A 365
ILE A 356
GLY A 256
ILE A 257
ILE A 362
 None
None
None
None
PO4  A 608 (-3.8A)
 1.13A 5kr0A-4gx0A:
undetectable		 5kr0A-4gx0A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ILE A 439
ILE A 426
LEU A 430
HIS A 434
 None
 1.00A 5vkqA-4gx0A:
8.2
5vkqB-4gx0A:
8.3		 5vkqA-4gx0A:
16.40
5vkqB-4gx0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ILE A 439
ILE A 426
LEU A 430
HIS A 434
 None
 0.99A 5vkqA-4gx0A:
8.2
5vkqD-4gx0A:
8.2		 5vkqA-4gx0A:
16.40
5vkqD-4gx0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 TYR A 179
VAL A 177
VAL A 159
THR A 160
 None
 1.31A 6f32B-4gx0A:
5.1		 6f32B-4gx0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gx0 TRKA DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A 199
ALA A 225
VAL A 244
ASP A 139
 None
 1.02A 6hu9a-4gx0A:
1.9
6hu9e-4gx0A:
undetectable		 6hu9a-4gx0A:
23.13
6hu9e-4gx0A:
12.68