SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		4 / 8 LEU A 619
VAL A 674
GLY A 675
LEU A 608
 None
 0.94A 1jlbA-4gx7A:
undetectable		 1jlbA-4gx7A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		5 / 11 LEU A 626
GLY A 632
GLY A 631
ILE A 616
LEU A 639
 None
MMA  A 801 (-3.3A)
MMA  A 801 ( 3.7A)
None
None
 1.19A 1p91A-4gx7A:
undetectable		 1p91A-4gx7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		4 / 7 VAL A 610
VAL A 711
LEU A 590
LEU A 608
 None
 0.87A 1pthA-4gx7A:
undetectable		 1pthA-4gx7A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		4 / 7 VAL A 610
VAL A 711
LEU A 590
LEU A 608
 None
 0.86A 1pthB-4gx7A:
undetectable		 1pthB-4gx7A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		6 / 12 VAL A 711
VAL A 708
ILE A 701
ILE A 616
GLY A 675
VAL A 680
 None
 1.46A 4y8wC-4gx7A:
undetectable		 4y8wC-4gx7A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN
(Vibrio
cholerae) 		3 / 3 ASP A 605
SER A 636
TYR A 609
 None
 0.91A 5glmA-4gx7A:
undetectable		 5glmA-4gx7A:
22.13