SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.63A 1fbmB-4gxbA:
undetectable		 1fbmB-4gxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.34A 1fbmD-4gxbA:
undetectable		 1fbmD-4gxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.80A 1mz9D-4gxbA:
undetectable		 1mz9D-4gxbA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		3 / 3 SER A 312
GLY A 311
ARG A 267
 None
 0.63A 1t9wA-4gxbA:
undetectable		 1t9wA-4gxbA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 11 LEU A 123
LEU A 201
ARG A 202
PHE A 160
LEU A 224
 None
None
GOL  A 401 (-4.1A)
None
None
 1.17A 2qjuA-4gxbA:
undetectable		 2qjuA-4gxbA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 5 GLN A 227
PHE A 175
TRP A 236
GLY A 126
 None
None
GOL  A 401 (-3.8A)
None
 1.26A 2qmzA-4gxbA:
undetectable
2qmzB-4gxbA:
undetectable		 2qmzA-4gxbA:
22.70
2qmzB-4gxbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 6 LEU A 297
SER A 298
ILE A 364
CYH A 277
 None
 0.89A 3ko0B-4gxbA:
undetectable		 3ko0B-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 6 LEU A 297
SER A 298
ILE A 364
CYH A 277
 None
 0.93A 3ko0S-4gxbA:
undetectable		 3ko0S-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		3 / 3 PHE A 274
SER A 366
GLN A 368
 None
 0.84A 3smtA-4gxbA:
undetectable		 3smtA-4gxbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		3 / 3 ARG A 234
LYS A 168
ARG A 273
 None
 1.37A 3w1wA-4gxbA:
undetectable
3w1wB-4gxbA:
undetectable		 3w1wA-4gxbA:
22.05
3w1wB-4gxbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		3 / 3 ARG A 273
ARG A 234
LYS A 168
 None
 1.44A 3w1wA-4gxbA:
undetectable
3w1wB-4gxbA:
undetectable		 3w1wA-4gxbA:
22.05
3w1wB-4gxbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 8 GLY A 340
GLY A 332
LEU A 329
GLU A 343
 None
 0.73A 4mwzB-4gxbA:
undetectable		 4mwzB-4gxbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 12 ALA A 292
LEU A 376
PHE A 274
SER A 366
ILE A 364
 None
 1.24A 4pb1A-4gxbA:
undetectable		 4pb1A-4gxbA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 12 ALA A 292
LEU A 376
PHE A 274
SER A 366
ILE A 364
 None
 1.17A 4pd9A-4gxbA:
undetectable		 4pd9A-4gxbA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		3 / 3 ALA A 349
TRP A 361
VAL A 362
 None
 0.17A 4w9nC-4gxbA:
undetectable		 4w9nC-4gxbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 12 LEU A 376
VAL A 362
TYR A 352
PHE A 313
LEU A 297
 None
 1.41A 5cymA-4gxbA:
undetectable		 5cymA-4gxbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 12 LEU A 376
VAL A 362
TYR A 352
PHE A 313
LEU A 297
 None
 1.41A 5cyqA-4gxbA:
undetectable		 5cyqA-4gxbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		4 / 8 PHE A 160
TYR A 205
GLY A 220
LEU A 260
 None
 0.81A 5esfA-4gxbA:
undetectable		 5esfA-4gxbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4gxb SORTING NEXIN-17
(Homo
sapiens) 		5 / 12 LEU A 376
VAL A 362
TYR A 352
PHE A 313
LEU A 297
 None
 1.41A 6eliA-4gxbA:
undetectable		 6eliA-4gxbA:
12.73