SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 12 GLY A 373
LEU A 395
GLY A 436
PHE A 376
VAL A 459
 None
 1.07A 1fduA-4gxpA:
2.2		 1fduA-4gxpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 11 ASN A 172
GLU A 173
TYR A 302
GLU A 371
TRP A 419
 None
 0.78A 2v3dB-4gxpA:
2.9		 2v3dB-4gxpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 4 ASP A 378
ASP A 451
SER A 452
ARG A 391
 None
 1.32A 2z0aC-4gxpA:
0.0		 2z0aC-4gxpA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 8 PHE A 158
VAL A 219
GLY A 222
GLY A 162
 None
 0.75A 3n9jB-4gxpA:
undetectable		 3n9jB-4gxpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 12 GLY A 209
GLY A 225
ASP A 295
TYR A 263
ILE A 262
 None
 1.00A 3prsA-4gxpA:
undetectable		 3prsA-4gxpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 7 GLY A  30
ASP A  59
GLY A  58
HIS A  47
 None
 0.83A 4c5nA-4gxpA:
2.9		 4c5nA-4gxpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 8 GLY A  30
ASP A  59
GLY A  58
HIS A  47
 None
 0.80A 4c5nC-4gxpA:
2.9		 4c5nC-4gxpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 7 ASP A  63
GLN A 445
ASN A  66
TRP A  68
 None
 1.08A 4ii8A-4gxpA:
undetectable		 4ii8A-4gxpA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 7 VAL A 403
MET A 402
ALA A 401
PHE A 351
 None
 0.97A 4lb2A-4gxpA:
undetectable		 4lb2A-4gxpA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		3 / 3 ASP A 130
TRP A 419
SER A  86
 None
 0.82A 4lrhB-4gxpA:
undetectable		 4lrhB-4gxpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 12 VAL A  21
SER A 452
ASP A 423
GLY A 453
ASP A 388
 None
 1.40A 4pevB-4gxpA:
undetectable		 4pevB-4gxpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 12 VAL A  21
SER A 452
ASP A 423
GLY A 453
ASP A 388
 None
 1.35A 4pevC-4gxpA:
undetectable		 4pevC-4gxpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		3 / 3 ASN A 172
PHE A 417
TYR A  83
 None
 0.67A 4u15A-4gxpA:
undetectable		 4u15A-4gxpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 6 PHE A 417
ALA A  82
TYR A 368
ASN A 167
 None
 1.28A 5cadA-4gxpA:
undetectable		 5cadA-4gxpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		4 / 4 ALA A 288
PRO A 261
LEU A 279
HIS A 202
 None
 1.21A 5eskA-4gxpA:
undetectable		 5eskA-4gxpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		5 / 12 ARG A 210
PHE A 127
PHE A 171
ILE A 146
THR A  97
 None
 1.02A 5veuH-4gxpA:
undetectable		 5veuH-4gxpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN
(Thermotoga
maritima;
Trichoderma
reesei) 		3 / 3 TRP A  19
ILE A 399
GLU A 407
 None
 0.86A 6hcxA-4gxpA:
undetectable		 6hcxA-4gxpA:
12.74