SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		5 / 12 PHE A  42
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 0.94A 1cbrA-4gxtA:
undetectable		 1cbrA-4gxtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		5 / 12 PHE A  42
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 0.94A 1cbrB-4gxtA:
undetectable		 1cbrB-4gxtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		6 / 12 PHE A  42
LEU A 226
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 0.97A 1cbsA-4gxtA:
undetectable		 1cbsA-4gxtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 6 PHE A 140
PHE A  67
LEU A  58
MET A 164
 None
 0.90A 1hk1A-4gxtA:
undetectable		 1hk1A-4gxtA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 7 LEU A 333
PHE A 371
MET A 223
VAL A 224
 None
 1.04A 1wrlA-4gxtA:
undetectable
1wrlB-4gxtA:
undetectable		 1wrlA-4gxtA:
13.49
1wrlB-4gxtA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		5 / 12 MET A 313
LEU A 226
SER A 356
SER A  13
ILE A  18
 None
 1.39A 1xotA-4gxtA:
undetectable		 1xotA-4gxtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		6 / 12 PHE A  42
LEU A 226
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 1.02A 2fr3A-4gxtA:
undetectable		 2fr3A-4gxtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 8 LEU A 226
LEU A  21
LYS A  20
ASN A  19
 None
 0.99A 2xn3A-4gxtA:
undetectable
2xn3B-4gxtA:
undetectable		 2xn3A-4gxtA:
21.83
2xn3B-4gxtA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 SER A 318
GLU A  54
ASP A 246
 None
 0.79A 2zulA-4gxtA:
2.1		 2zulA-4gxtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 SER A 318
GLU A  54
ASP A 246
 None
 0.80A 3dmhA-4gxtA:
2.3		 3dmhA-4gxtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 6 GLY A  51
GLU A  55
GLY A 216
ASN A  46
 GOL  A 405 ( 3.7A)
GOL  A 405 (-3.1A)
None
GOL  A 405 (-2.8A)
 0.87A 3e9rA-4gxtA:
undetectable		 3e9rA-4gxtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 6 GLY A  51
GLU A  55
GLY A 216
ASN A  46
 GOL  A 405 ( 3.7A)
GOL  A 405 (-3.1A)
None
GOL  A 405 (-2.8A)
 0.85A 3e9rC-4gxtA:
undetectable		 3e9rC-4gxtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		5 / 12 GLY A 234
ILE A 239
LEU A 267
TYR A  32
ASN A 308
 None
 1.09A 3eeoA-4gxtA:
undetectable		 3eeoA-4gxtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 5 HIS A 338
SER A 377
SER A 374
VAL A 372
 None
 1.41A 4a99D-4gxtA:
undetectable		 4a99D-4gxtA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 ARG A 249
GLU A 264
ARG A 270
 None
 0.96A 4mwvA-4gxtA:
undetectable		 4mwvA-4gxtA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		5 / 12 GLY A 316
GLY A 315
ASP A 321
ASP A 319
ILE A 337
 None
 1.15A 4pghD-4gxtA:
undetectable		 4pghD-4gxtA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 ASP A 246
ARG A 249
TYR A 177
 None
 0.99A 5a7mA-4gxtA:
3.4		 5a7mA-4gxtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 ASP A 246
ARG A 249
TYR A 177
 None
 0.96A 5a7mB-4gxtA:
3.4		 5a7mB-4gxtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		3 / 3 THR A 298
SER A 290
ASP A 284
 None
 0.85A 5kvaA-4gxtA:
2.7		 5kvaA-4gxtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN
(Anaerococcus
prevotii) 		4 / 5 LEU A 226
TYR A 227
ILE A 192
GLY A 315
 None
 1.02A 6hd6A-4gxtA:
undetectable		 6hd6A-4gxtA:
11.62