SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  34
HIS A  36
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.53A 1a4lA-4gxwA:
39.7		 1a4lA-4gxwA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  36
LEU A  76
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.58A 1a4lB-4gxwA:
39.6		 1a4lB-4gxwA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  34
HIS A  36
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.51A 1a4lC-4gxwA:
39.5		 1a4lC-4gxwA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		6 / 12 HIS A  36
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.47A 1a4lD-4gxwA:
39.6		 1a4lD-4gxwA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 LEU A  87
ILE A  62
ARG A  59
VAL A  41
 None
 1.04A 1db1A-4gxwA:
undetectable		 1db1A-4gxwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 5 ASP A 300
HIS A  36
HIS A 240
HIS A 215
 ZN  A 401 (-2.6A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
 1.08A 1ei6A-4gxwA:
undetectable		 1ei6A-4gxwA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 PRO A   9
THR A   4
PRO A   5
GLY A   6
 None
 0.78A 1h4oB-4gxwA:
undetectable		 1h4oB-4gxwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 PRO A   9
THR A   4
PRO A   5
GLY A   6
 None
 0.80A 1h4oG-4gxwA:
undetectable		 1h4oG-4gxwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 GLY A 241
VAL A 245
ALA A 214
GLY A 220
TYR A 270
 None
 1.12A 1kiaA-4gxwA:
undetectable		 1kiaA-4gxwA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 GLY A 241
VAL A 245
ALA A 214
GLY A 220
TYR A 270
 None
 1.12A 1kiaB-4gxwA:
undetectable		 1kiaB-4gxwA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 GLY A 241
VAL A 245
ALA A 214
GLY A 220
TYR A 270
 None
 1.13A 1kiaC-4gxwA:
undetectable		 1kiaC-4gxwA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 ALA A  10
VAL A   8
TRP A 279
 None
 0.80A 1kqeA-4gxwA:
undetectable
1kqeE-4gxwA:
undetectable		 1kqeA-4gxwA:
3.32
1kqeE-4gxwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 ALA A  10
VAL A   8
TRP A 279
 None
 0.83A 1kqeB-4gxwA:
undetectable
1kqeD-4gxwA:
undetectable		 1kqeB-4gxwA:
3.32
1kqeD-4gxwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 TRP A 279
ALA A  10
VAL A   8
 None
 0.82A 1kqeB-4gxwA:
undetectable
1kqeD-4gxwA:
undetectable		 1kqeB-4gxwA:
3.32
1kqeD-4gxwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 TRP A 279
ALA A  10
VAL A   8
 None
 0.82A 1kqeA-4gxwA:
undetectable
1kqeE-4gxwA:
undetectable		 1kqeA-4gxwA:
3.32
1kqeE-4gxwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 ALA A  10
VAL A   8
TRP A 279
 None
 0.82A 1micA-4gxwA:
undetectable
1micB-4gxwA:
undetectable		 1micA-4gxwA:
5.22
1micB-4gxwA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 5 GLU A  99
ARG A  52
ASP A  92
LEU A  87
 None
 0.95A 1n13B-4gxwA:
undetectable
1n13C-4gxwA:
undetectable		 1n13B-4gxwA:
14.89
1n13C-4gxwA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 7 ASP A  92
LEU A  87
GLU A  99
ARG A  52
 None
 0.93A 1n13I-4gxwA:
undetectable
1n13L-4gxwA:
undetectable		 1n13I-4gxwA:
10.09
1n13L-4gxwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 PRO A   9
THR A   4
PRO A   5
GLY A   6
 None
 0.80A 1oc3A-4gxwA:
undetectable		 1oc3A-4gxwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 ASP A  83
LEU A  87
HIS A 305
 None
 0.78A 1qknA-4gxwA:
undetectable		 1qknA-4gxwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 4 HIS A 215
GLU A 218
HIS A 240
HIS A  34
 ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-3.4A)
 1.15A 1utzA-4gxwA:
undetectable		 1utzA-4gxwA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 ILE A 154
HIS A  36
HIS A  34
HIS A 215
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
 0.89A 1y93A-4gxwA:
undetectable		 1y93A-4gxwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 11 HIS A  34
VAL A 264
HIS A 240
HIS A 215
THR A 299
 ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-3.4A)
None
 1.31A 2dttD-4gxwA:
undetectable
2dttE-4gxwA:
undetectable		 2dttD-4gxwA:
15.61
2dttE-4gxwA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 4 HIS A 215
GLU A 218
HIS A 240
HIS A  34
 ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-3.4A)
 1.18A 2hu6A-4gxwA:
undetectable		 2hu6A-4gxwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 PHE A 261
ARG A 237
ASN A 298
LEU A  79
 None
 1.15A 2nyrA-4gxwA:
undetectable		 2nyrA-4gxwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		6 / 12 HIS A  36
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.50A 2pgfA-4gxwA:
38.4		 2pgfA-4gxwA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  34
HIS A  36
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.52A 2pgrA-4gxwA:
38.5		 2pgrA-4gxwA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 PRO A 195
ASN A 225
ARG A 224
 None
 1.00A 2qeuB-4gxwA:
undetectable		 2qeuB-4gxwA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 GLU A  99
ARG A  52
ASP A  92
LEU A  87
 None
 0.86A 2qqdB-4gxwA:
undetectable
2qqdC-4gxwA:
undetectable		 2qqdB-4gxwA:
14.89
2qqdC-4gxwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 TYR A  66
ILE A  62
LEU A  82
LEU A  87
 None
 0.71A 2vctA-4gxwA:
undetectable		 2vctA-4gxwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 TYR A  66
ILE A  62
LEU A  82
LEU A  87
 None
 0.70A 2vctB-4gxwA:
undetectable		 2vctB-4gxwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A  34
ILE A 154
HIS A 215
ASP A 239
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.4A)
None
 1.08A 2xadA-4gxwA:
undetectable		 2xadA-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 215
ILE A 154
HIS A  36
ASP A 187
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.3A)
None
 0.96A 2xadA-4gxwA:
undetectable		 2xadA-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A  34
ILE A 154
HIS A 215
ASP A 239
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.4A)
None
 1.13A 2xadB-4gxwA:
undetectable		 2xadB-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 215
ILE A 154
HIS A  36
ASP A 187
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.3A)
None
 0.98A 2xadB-4gxwA:
undetectable		 2xadB-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A  34
ILE A 154
HIS A 215
ASP A 239
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.4A)
None
 1.09A 2xadC-4gxwA:
undetectable		 2xadC-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 215
ILE A 154
HIS A  36
ASP A 187
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.3A)
None
 0.97A 2xadC-4gxwA:
undetectable		 2xadC-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A  34
ILE A 154
HIS A 215
ASP A 239
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.4A)
None
 1.07A 2xadD-4gxwA:
undetectable		 2xadD-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 215
ILE A 154
HIS A  36
ASP A 187
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.3A)
None
 0.96A 2xadD-4gxwA:
undetectable		 2xadD-4gxwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 THR A 213
ASP A 300
HIS A 296
HIS A 240
PHE A 115
 None
ZN  A 401 (-2.6A)
None
None
None
 1.35A 2zj0D-4gxwA:
undetectable		 2zj0D-4gxwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 ARG A 272
ASP A 301
ASN A 267
 None
 0.86A 2zzmA-4gxwA:
undetectable		 2zzmA-4gxwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 5 HIS A  34
HIS A 215
ASP A 300
ASP A 301
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-2.6A)
None
 1.13A 3c0zA-4gxwA:
undetectable		 3c0zA-4gxwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 HIS A  34
HIS A 215
ASP A 300
ASP A 301
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-2.6A)
None
 1.16A 3c0zC-4gxwA:
undetectable		 3c0zC-4gxwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 VAL A 137
ALA A 143
ALA A 144
LEU A 101
VAL A 181
 None
 0.92A 3fc6C-4gxwA:
undetectable		 3fc6C-4gxwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 4 HIS A 215
GLU A 218
HIS A 240
HIS A  34
 ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-3.4A)
 1.20A 3lilA-4gxwA:
undetectable		 3lilA-4gxwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 HIS A 240
HIS A 215
HIS A  34
ASP A 301
 None
ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
None
 0.66A 3nvcA-4gxwA:
undetectable		 3nvcA-4gxwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 HIS A 215
HIS A  34
HIS A  36
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 0.60A 3qpkA-4gxwA:
undetectable		 3qpkA-4gxwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 HIS A 215
HIS A  34
HIS A  36
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 0.61A 3qpkB-4gxwA:
undetectable		 3qpkB-4gxwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 11 LEU A 232
ASP A 236
GLY A 185
ILE A 157
THR A 228
 None
 1.04A 3spkA-4gxwA:
undetectable		 3spkA-4gxwA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 7 ASN A 117
ASP A 300
HIS A  34
HIS A 215
 None
ZN  A 401 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
 1.07A 3t01A-4gxwA:
undetectable		 3t01A-4gxwA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 HIS A 215
GLU A 218
GLU A 190
HIS A 240
ASP A 300
 ZN  A 401 (-3.4A)
None
None
None
ZN  A 401 (-2.6A)
 0.70A 4aqlA-4gxwA:
20.4		 4aqlA-4gxwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 LEU A  76
HIS A 215
GLU A 218
HIS A 240
ASP A 300
 None
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
 0.85A 4aqlA-4gxwA:
20.4		 4aqlA-4gxwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 4 HIS A  34
HIS A  36
HIS A 240
HIS A 215
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
 0.96A 4ef3A-4gxwA:
undetectable		 4ef3A-4gxwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 ASN A 225
ARG A 159
TYR A 202
LEU A 233
 None
 1.19A 4f8yA-4gxwA:
undetectable
4f8yB-4gxwA:
undetectable		 4f8yA-4gxwA:
19.95
4f8yB-4gxwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 THR A 213
ASP A 300
HIS A 296
HIS A 240
PHE A 115
 None
ZN  A 401 (-2.6A)
None
None
None
 1.42A 4lvcB-4gxwA:
undetectable		 4lvcB-4gxwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 5 ASN A 298
LEU A  33
HIS A 296
GLU A  32
 None
 1.44A 4p6sA-4gxwA:
undetectable		 4p6sA-4gxwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 5 HIS A 111
VAL A  31
GLU A 113
VAL A 340
 None
 1.24A 4p6vB-4gxwA:
0.4
4p6vE-4gxwA:
undetectable		 4p6vB-4gxwA:
21.78
4p6vE-4gxwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 ASP A 158
LEU A  76
LEU A  79
GLY A  39
HIS A  36
 None
None
None
None
ZN  A 401 (-3.3A)
 1.36A 4pgfB-4gxwA:
undetectable		 4pgfB-4gxwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 THR A 213
ASP A 300
HIS A 296
HIS A 240
PHE A 115
 None
ZN  A 401 (-2.6A)
None
None
None
 1.43A 5hm8D-4gxwA:
undetectable		 5hm8D-4gxwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 THR A 213
ASP A 300
HIS A 296
HIS A 240
PHE A 115
 None
ZN  A 401 (-2.6A)
None
None
None
 1.42A 5hm8F-4gxwA:
undetectable		 5hm8F-4gxwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 GLU A 190
THR A 213
TYR A 242
PHE A 219
 None
 1.07A 5lrbA-4gxwA:
1.8		 5lrbA-4gxwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		3 / 3 HIS A 215
HIS A  34
HIS A  36
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 0.57A 5migA-4gxwA:
undetectable		 5migA-4gxwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 4 HIS A 215
GLU A 218
HIS A 240
HIS A  34
 ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-3.4A)
 1.19A 5n5jA-4gxwA:
undetectable		 5n5jA-4gxwA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 6 ASP A 301
HIS A 305
HIS A  36
HIS A  34
 None
None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
 0.92A 5nelA-4gxwA:
2.8
5nelD-4gxwA:
4.2		 5nelA-4gxwA:
19.79
5nelD-4gxwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		5 / 12 GLY A 337
VAL A 230
ARG A 237
VAL A 238
ASP A 239
 None
 1.29A 6bxlB-4gxwA:
undetectable		 6bxlB-4gxwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		4 / 8 VAL A 263
TRP A 279
TYR A 270
GLU A 190
 None
 1.06A 6gneB-4gxwA:
2.3		 6gneB-4gxwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  36
LEU A  76
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.47A 6n91A-4gxwA:
40.5		 6n91A-4gxwA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4gxw ADENOSINE DEAMINASE
(Burkholderia
ambifaria) 		7 / 12 HIS A  36
LEU A  76
HIS A 215
GLU A 218
HIS A 240
ASP A 300
ASP A 301
 ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.4A)
None
None
ZN  A 401 (-2.6A)
None
 0.48A 6n91B-4gxwA:
40.5		 6n91B-4gxwA:
11.08