SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.54A 1oe1A-4gybA:
21.2
1oe1A-4gybA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.54A 1oe2A-4gybA:
12.7
1oe2A-4gybA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.57A 1oe3A-4gybA:
21.3
1oe3A-4gybA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 SER A 120
ARG A 128
HIS A 104
HIS A 156
None
0.97A 1s19A-4gybA:
undetectable
1s19A-4gybA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 HIS A 102
HIS A 156
HIS A 158
None
0.72A 1w2zC-4gybA:
undetectable
1w2zC-4gybA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.50A 2fqdA-4gybA:
17.8
2fqdA-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.46A 2fqeA-4gybA:
17.8
2fqeA-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.48A 2fqfA-4gybA:
17.8
2fqfA-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.50A 2fqgA-4gybA:
undetectable
2fqgA-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 LYS A  36
GLY A 250
PRO A 251
None
0.92A 2hreB-4gybA:
undetectable
2hreB-4gybA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
5 / 12 ILE A 193
ALA A 213
VAL A 304
PHE A 233
HIS A 234
None
None
None
None
CU  A 404 (-3.1A)
1.06A 2qo6A-4gybA:
undetectable
2qo6A-4gybA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 TRP A 240
GLN A 272
TRP A 284
None
1.00A 2vqyA-4gybA:
undetectable
2vqyA-4gybA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.53A 2xxgA-4gybA:
13.5
2xxgA-4gybA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.56A 2xxgC-4gybA:
11.0
2xxgC-4gybA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 HIS A 156
HIS A 104
HIS A 154
None
0.72A 3ag4A-4gybA:
undetectable
3ag4A-4gybA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 ILE A 193
PHE A 233
ILE A 221
THR A 225
None
1.01A 3ia4A-4gybA:
undetectable
3ia4A-4gybA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 HIS A 287
HIS A 234
HIS A 236
CU  A 403 (-3.4A)
CU  A 404 (-3.1A)
CU  A 403 ( 3.2A)
0.83A 3mihA-4gybA:
undetectable
3mihA-4gybA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 HIS A 287
HIS A 236
MET A 285
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
CU  A 403 ( 4.6A)
0.64A 3mihA-4gybA:
undetectable
3mihA-4gybA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
5 / 12 TYR A 155
ILE A 193
PHE A 195
THR A 192
ILE A 221
None
None
None
CL  A 406 (-4.5A)
None
1.33A 3ndiA-4gybA:
undetectable
3ndiA-4gybA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 4 HIS A 231
CYH A 288
HIS A 293
MET A 298
CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
0.49A 4ef3A-4gybA:
17.7
4ef3A-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
5 / 12 MET A  53
LEU A  51
VAL A 103
LEU A 101
LEU A  87
None
1.27A 4m11A-4gybA:
undetectable
4m11A-4gybA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 GLY A  66
ALA A  72
GLY A  76
PRO A  77
None
0.94A 4u9uA-4gybA:
undetectable
4u9uA-4gybA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 GLY A  66
ALA A  72
GLY A  76
PRO A  77
None
0.95A 4u9uB-4gybA:
undetectable
4u9uB-4gybA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 ILE A  89
LEU A  78
HIS A 154
VAL A 103
None
PGE  A 409 (-4.9A)
None
None
1.20A 5jmnB-4gybA:
undetectable
5jmnB-4gybA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mhwA-4gybA:
11.6
5mhwA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mhxA-4gybA:
11.6
5mhxA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mhyA-4gybA:
11.6
5mhyA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mhzA-4gybA:
18.9
5mhzA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mi1A-4gybA:
18.9
5mi1A-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mi2A-4gybA:
18.9
5mi2A-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5miaA-4gybA:
11.6
5miaA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mibA-4gybA:
18.8
5mibA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.93A 5micA-4gybA:
11.6
5micA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5midA-4gybA:
11.6
5midA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5mieA-4gybA:
11.6
5mieA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 5 HIS A 289
HIS A 234
HIS A 287
HIS A 236
CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
0.92A 5migA-4gybA:
11.6
5migA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 7 ALA A 213
THR A 214
GLN A 272
VAL A 219
None
0.96A 6cduA-4gybA:
undetectable
6cduE-4gybA:
undetectable
6cduA-4gybA:
19.11
6cduE-4gybA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 6 GLN A 272
VAL A 219
ALA A 213
THR A 214
None
0.88A 6cduB-4gybA:
undetectable
6cduC-4gybA:
undetectable
6cduB-4gybA:
19.11
6cduC-4gybA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 7 GLN A 272
VAL A 219
ALA A 213
THR A 214
None
0.91A 6cduC-4gybA:
undetectable
6cduD-4gybA:
undetectable
6cduC-4gybA:
19.11
6cduD-4gybA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
4 / 7 ALA A 213
THR A 214
GLN A 272
VAL A 219
None
0.91A 6cduF-4gybA:
undetectable
6cduJ-4gybA:
undetectable
6cduF-4gybA:
19.11
6cduJ-4gybA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
4gyb COPPER OXIDASE
(Streptomyces
lividans)
3 / 3 HIS A 156
HIS A 104
HIS A 154
None
0.73A 6giqa-4gybA:
undetectable
6giqa-4gybA:
20.48