SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 5 PHE A 117
GLY A 100
THR A  26
PHE A  23
 None
 1.37A 1icuC-4gymA:
undetectable
1icuD-4gymA:
undetectable		 1icuC-4gymA:
22.22
1icuD-4gymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		5 / 12 GLY A 122
ASP A 121
ARG A  56
ALA A  70
ALA A  68
 None
 1.15A 2br4D-4gymA:
undetectable		 2br4D-4gymA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.30A 3n5tA-4gymA:
undetectable
3n5tB-4gymA:
undetectable		 3n5tA-4gymA:
17.16
3n5tB-4gymA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.22A 3n61A-4gymA:
undetectable
3n61B-4gymA:
undetectable		 3n61A-4gymA:
16.62
3n61B-4gymA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		5 / 12 PHE A  24
MET A  43
VAL A  51
ASP A 119
PHE A  23
 None
 1.44A 4c9wA-4gymA:
undetectable		 4c9wA-4gymA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 8 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.24A 4capA-4gymA:
undetectable
4capB-4gymA:
undetectable		 4capA-4gymA:
15.86
4capB-4gymA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 8 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.27A 4cx7A-4gymA:
undetectable
4cx7B-4gymA:
undetectable		 4cx7A-4gymA:
16.01
4cx7B-4gymA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.31A 4k5jA-4gymA:
undetectable
4k5jB-4gymA:
undetectable		 4k5jA-4gymA:
16.12
4k5jB-4gymA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.23A 5fj3A-4gymA:
undetectable
5fj3B-4gymA:
undetectable		 5fj3A-4gymA:
16.12
5fj3B-4gymA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 8 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.21A 5uo7A-4gymA:
undetectable
5uo7B-4gymA:
undetectable		 5uo7A-4gymA:
15.71
5uo7B-4gymA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 6 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.22A 5uo8A-4gymA:
undetectable
5uo8B-4gymA:
undetectable		 5uo8A-4gymA:
16.44
5uo8B-4gymA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.29A 5vv7A-4gymA:
undetectable
5vv7B-4gymA:
undetectable		 5vv7A-4gymA:
16.12
5vv7B-4gymA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.28A 5vvnA-4gymA:
undetectable
5vvnB-4gymA:
undetectable		 5vvnA-4gymA:
16.12
5vvnB-4gymA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 PHE A  91
GLU A 126
SER A 116
TRP A 125
 None
 1.26A 6av6C-4gymA:
undetectable
6av6D-4gymA:
undetectable		 6av6C-4gymA:
21.92
6av6D-4gymA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gym GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Conexibacter
woesei) 		4 / 7 SER A 116
TRP A 125
PHE A  91
GLU A 126
 None
 1.29A 6av7A-4gymA:
undetectable
6av7B-4gymA:
undetectable		 6av7A-4gymA:
21.92
6av7B-4gymA:
21.92