SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		3 / 3 ALA A 247
VAL A 259
TRP A 292
 None
 0.88A 1c4dC-4gyoA:
undetectable
1c4dD-4gyoA:
undetectable		 1c4dC-4gyoA:
3.64
1c4dD-4gyoA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 8 LEU A 317
TYR A 308
GLY A 310
LEU A 303
 None
 0.95A 1jlbA-4gyoA:
2.2		 1jlbA-4gyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 6 GLN A 212
VAL A 180
ALA A 206
SER A 205
 None
 0.97A 1p6kA-4gyoA:
undetectable		 1p6kA-4gyoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 8 LEU A 317
TYR A 308
GLY A 310
LEU A 303
 None
 0.95A 1s1xA-4gyoA:
undetectable		 1s1xA-4gyoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		3 / 3 TYR A 297
GLY A 285
PHE A 263
 None
 0.69A 2m2pB-4gyoA:
undetectable		 2m2pB-4gyoA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 8 GLU A 183
LEU A 166
HIS A 202
SER A 205
 None
 0.80A 2q0iA-4gyoA:
undetectable		 2q0iA-4gyoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 5 ARG A 178
ILE A  62
GLU A 140
LYS A 144
 None
 1.50A 2xrzA-4gyoA:
undetectable
2xrzB-4gyoA:
undetectable		 2xrzA-4gyoA:
22.58
2xrzB-4gyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		5 / 12 HIS A 151
LEU A 166
SER A 163
MET A 159
ARG A 179
 None
 1.30A 3bxoA-4gyoA:
undetectable		 3bxoA-4gyoA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		5 / 12 HIS A 151
LEU A 166
SER A 163
MET A 159
ARG A 179
 None
 1.48A 3bxoB-4gyoA:
undetectable		 3bxoB-4gyoA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 5 TYR A 242
ALA A 206
ALA A 220
TYR A 217
 None
 1.26A 3d91A-4gyoA:
undetectable		 3d91A-4gyoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 5 PHE A 101
TYR A 108
LEU A  96
ARG A  59
 None
 1.35A 3sudD-4gyoA:
undetectable		 3sudD-4gyoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		3 / 3 TYR A 108
LEU A  96
ARG A  59
 None
 0.64A 3sufB-4gyoA:
undetectable		 3sufB-4gyoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 7 TYR A  18
ILE A  86
LEU A  96
LEU A  97
 None
 0.94A 4l1wA-4gyoA:
undetectable		 4l1wA-4gyoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 7 ILE A 185
HIS A 202
LEU A 203
ALA A 206
 None
 0.94A 5hrqE-4gyoA:
undetectable
5hrqF-4gyoA:
undetectable
5hrqJ-4gyoA:
undetectable		 5hrqE-4gyoA:
5.97
5hrqF-4gyoA:
6.41
5hrqJ-4gyoA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		4 / 5 LEU A  97
TYR A  99
LEU A  55
TYR A  52
 None
 1.30A 5ki6A-4gyoA:
undetectable		 5ki6A-4gyoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J
(Bacillus
subtilis) 		5 / 12 THR A 266
VAL A 262
PHE A 301
SER A 288
TYR A 224
 None
 1.49A 6h7mA-4gyoA:
undetectable		 6h7mA-4gyoA:
11.37