SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		5 / 12 LEU C 119
ALA C 117
THR C 378
VAL C  40
LEU C 382
 None
 1.26A 1cbrA-4gypC:
undetectable		 1cbrA-4gypC:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		5 / 12 LEU C 119
ALA C 117
THR C 378
VAL C  40
LEU C 382
 None
 1.26A 1cbrB-4gypC:
undetectable		 1cbrB-4gypC:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 8 LEU C 190
SER C 194
GLY C 199
TRP C 173
 None
 0.87A 1fapB-4gypC:
undetectable		 1fapB-4gypC:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 8 GLN C  84
ASN C  80
ARG C 323
LEU C 120
 None
PEG  C 503 (-3.5A)
None
None
 1.05A 1hk3A-4gypC:
undetectable		 1hk3A-4gypC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		5 / 9 LEU C 382
ILE C 384
THR C 366
THR C 351
ALA C 348
 None
 1.19A 2m9qA-4gypC:
undetectable		 2m9qA-4gypC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 8 TYR C 163
HIS C  31
GLY C 154
ILE C 153
 None
CIT  C 501 (-3.9A)
None
None
 0.87A 2zm9A-4gypC:
undetectable		 2zm9A-4gypC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 7 PHE C 203
PHE C 226
SER C 194
TYR C 198
 None
 1.43A 3hggA-4gypC:
undetectable		 3hggA-4gypC:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 ARG C 421
SER C 339
ASP C 234
TYR C 149
 CIT  C 501 (-2.9A)
None
None
None
 1.45A 3jqaA-4gypC:
undetectable		 3jqaA-4gypC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 ARG C 421
SER C 339
ASP C 234
TYR C 149
 CIT  C 501 (-2.9A)
None
None
None
 1.43A 3jqaB-4gypC:
undetectable		 3jqaB-4gypC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 ARG C 421
SER C 339
ASP C 234
TYR C 149
 CIT  C 501 (-2.9A)
None
None
None
 1.43A 3jqaC-4gypC:
undetectable		 3jqaC-4gypC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 ARG C 421
SER C 339
ASP C 234
TYR C 149
 CIT  C 501 (-2.9A)
None
None
None
 1.43A 3jqaD-4gypC:
undetectable		 3jqaD-4gypC:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 ALA C 111
ILE C  60
VAL C  14
ASN C  38
 None
 1.11A 3nneG-4gypC:
undetectable		 3nneG-4gypC:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 LEU C 127
ARG C  78
ASN C  45
 None
 0.76A 3qxvD-4gypC:
undetectable		 3qxvD-4gypC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 HIS C 338
SER C 346
ASN C 341
 CIT  C 501 (-3.9A)
None
CIT  C 501 ( 4.8A)
 0.88A 3s8pB-4gypC:
undetectable		 3s8pB-4gypC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C 177
ARG C 197
TRP C 173
 None
 1.30A 4cpzC-4gypC:
undetectable		 4cpzC-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C 177
ARG C 197
TRP C 173
 None
 1.27A 4cpzE-4gypC:
undetectable		 4cpzE-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C 177
ARG C 197
TRP C 173
 None
 1.25A 4cpzF-4gypC:
undetectable		 4cpzF-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C 177
ARG C 197
TRP C 173
 None
 1.26A 4cpzG-4gypC:
undetectable		 4cpzG-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ARG C 177
ARG C 197
TRP C 173
 None
 1.31A 4cpzH-4gypC:
undetectable		 4cpzH-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 LYS C 224
LYS C 223
PRO C 227
 None
 1.24A 4dv1L-4gypC:
undetectable		 4dv1L-4gypC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 ASP C 393
VAL C 399
ASN C 128
 None
 0.79A 4lmnA-4gypC:
undetectable		 4lmnA-4gypC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 LEU C 205
LEU C 190
VAL C 187
PHE C 151
 None
None
None
CIT  C 501 ( 4.8A)
 1.04A 4uswA-4gypC:
undetectable		 4uswA-4gypC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		3 / 3 TRP C 239
GLU C 215
ASP C 234
 None
 0.64A 5gqbA-4gypC:
5.4		 5gqbA-4gypC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 7 THR C 256
VAL C 187
GLN C 214
GLU C 213
 None
 1.12A 5tudA-4gypC:
undetectable		 5tudA-4gypC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 5 HIS C  31
ASP C 234
GLY C 207
ASN C  26
 CIT  C 501 (-3.9A)
None
None
CIT  C 501 (-3.3A)
 1.18A 5x7pB-4gypC:
undetectable		 5x7pB-4gypC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 5 LEU C 377
THR C  36
PRO C 162
ARG C 156
 None
 1.04A 6ew0F-4gypC:
undetectable		 6ew0F-4gypC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		4 / 6 LEU C 377
THR C  36
PRO C 162
ARG C 156
 None
 1.04A 6ew0G-4gypC:
undetectable		 6ew0G-4gypC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN
(Escherichia
coli) 		5 / 12 GLY C 212
VAL C 233
ARG C 445
PRO C 235
GLY C 208
 None
 1.19A 6gngA-4gypC:
undetectable		 6gngA-4gypC:
23.83