SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 11 LEU A 192
PHE A  91
ALA A  86
VAL A 101
LEU A 165
 None
 1.15A 1hbpA-4gysA:
undetectable		 1hbpA-4gysA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 11 SER A 172
GLY A 166
VAL A 207
SER A 149
ILE A  77
 MLI  A1000 (-4.2A)
None
None
None
None
 1.13A 1pk9C-4gysA:
undetectable		 1pk9C-4gysA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 12 GLY A 446
GLY A 448
LEU A 182
ASP A 437
PRO A 455
 None
 0.87A 1zq9B-4gysA:
undetectable		 1zq9B-4gysA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 7 LEU A 367
THR A 369
GLY A 173
ASP A 168
 None
None
None
MLI  A1000 ( 4.7A)
 0.96A 2ddwB-4gysA:
undetectable		 2ddwB-4gysA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 5 LEU A   7
VAL A 420
LEU A 422
ARG A 442
 None
 1.07A 2oiqA-4gysA:
undetectable		 2oiqA-4gysA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 6 ALA A  53
ASP A  57
GLU A  52
ARG A  44
 None
 1.39A 2ouzA-4gysA:
undetectable		 2ouzA-4gysA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 7 TYR A  93
PHE A  91
ALA A 310
ALA A  86
 None
 0.95A 2vcvA-4gysA:
undetectable		 2vcvA-4gysA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 4 LEU A 192
ASP A  98
VAL A 197
THR A 167
 None
 1.27A 3cyxB-4gysA:
undetectable		 3cyxB-4gysA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 4 VAL A 138
TYR A 447
PRO A 408
PHE A 139
 None
 1.35A 3d91B-4gysA:
undetectable		 3d91B-4gysA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 7 THR A 208
VAL A 207
THR A 167
ILE A  77
SER A 152
 None
 1.38A 3deuA-4gysA:
0.5		 3deuA-4gysA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 7 PHE A 179
GLY A 147
GLY A 391
PHE A 139
 None
 0.96A 3ko0M-4gysA:
undetectable
3ko0P-4gysA:
undetectable		 3ko0M-4gysA:
9.26
3ko0P-4gysA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 12 GLY A 166
GLY A 147
SER A 172
ALA A 177
ALA A 178
 None
None
MLI  A1000 (-4.2A)
None
None
 1.17A 3sueB-4gysA:
undetectable		 3sueB-4gysA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 5 SER A 234
GLY A 190
THR A 100
VAL A 207
 None
 0.98A 4eohA-4gysA:
undetectable		 4eohA-4gysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 8 ALA A 211
SER A 213
LEU A   7
TYR A 447
 None
 1.18A 4ijiF-4gysA:
undetectable		 4ijiF-4gysA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 7 ASN A  76
ALA A 122
VAL A 311
ARG A 307
 None
MLI  A1000 (-3.9A)
None
MLI  A1000 (-3.0A)
 1.11A 4ijiH-4gysA:
undetectable		 4ijiH-4gysA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 4 ASP A  57
LEU A  56
ARG A  44
THR A  19
 None
 1.22A 4kjjA-4gysA:
undetectable		 4kjjA-4gysA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 5 GLY A 448
ARG A 451
GLU A 444
PHE A 411
 None
 1.19A 4r82A-4gysA:
undetectable
4r82B-4gysA:
undetectable		 4r82A-4gysA:
16.92
4r82B-4gysA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 12 GLY A  81
ALA A  80
ASP A  98
GLU A  48
GLU A  52
 None
 1.23A 4xt8A-4gysA:
undetectable		 4xt8A-4gysA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 6 ASP A 293
TYR A 393
PRO A 252
LEU A 365
 None
 0.91A 5bmvB-4gysA:
undetectable		 5bmvB-4gysA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 11 SER A 172
GLY A 166
VAL A 207
SER A 149
ILE A  77
 MLI  A1000 (-4.2A)
None
None
None
None
 1.24A 5i3cC-4gysA:
undetectable		 5i3cC-4gysA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 5 ILE A 220
LEU A 459
HIS A 440
VAL A 183
 None
 1.23A 5jmnB-4gysA:
undetectable		 5jmnB-4gysA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 4 ASN A 180
SER A 149
ALA A 153
VAL A 156
 None
 1.39A 5nm5A-4gysA:
undetectable		 5nm5A-4gysA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 6 GLY A 217
SER A 164
THR A 208
VAL A 185
 None
 0.93A 5ysiA-4gysA:
undetectable		 5ysiA-4gysA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		5 / 12 LEU A 113
GLY A 114
VAL A 207
ILE A  77
ASP A  75
 None
 1.14A 6bxmA-4gysA:
undetectable		 6bxmA-4gysA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4gys ALLOPHANATE
HYDROLASE
(Granulibacter
bethesdensis) 		4 / 4 LEU A 192
ASP A 429
PRO A 187
ARG A 221
 None
 1.37A 6fgdA-4gysA:
undetectable		 6fgdA-4gysA:
21.99