SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 9 ILE A 622
PHE A 596
VAL A 600
GLU A 601
 None
 0.78A 2vufA-4gyvA:
2.1		 2vufA-4gyvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 5 LEU A 547
GLN A 602
LEU A 604
GLU A 601
 None
 1.11A 3h5gA-4gyvA:
undetectable
3h5gB-4gyvA:
undetectable		 3h5gA-4gyvA:
10.55
3h5gB-4gyvA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 ARG A 628
GLU A 599
LEU A 547
ALA A 543
ARG A 603
 None
 1.48A 4cpzA-4gyvA:
undetectable		 4cpzA-4gyvA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 LEU A 557
LEU A 554
GLU A 550
TYR A 553
 None
 1.08A 4f3tA-4gyvA:
undetectable		 4f3tA-4gyvA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 PRO A 684
LEU A 554
GLU A 550
TYR A 553
 None
 1.14A 4z4cA-4gyvA:
undetectable		 4z4cA-4gyvA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4gyv FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 LEU A 557
PRO A 684
GLU A 550
TYR A 553
 None
 1.19A 4z4gA-4gyvA:
undetectable		 4z4gA-4gyvA:
12.56