SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 7 ASP A 156
LEU A 337
SER A 224
ASN A 228
 None
 1.23A 1ig3A-4gz2A:
undetectable
1ig3B-4gz2A:
undetectable		 1ig3A-4gz2A:
23.59
1ig3B-4gz2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 7 HIS A 236
SER A 239
ASP A 272
ARG A 276
 None
 1.40A 2rk8B-4gz2A:
undetectable		 2rk8B-4gz2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 6 PHE A 126
LEU A 337
ALA A 293
ALA A 270
 None
 0.93A 2vcvB-4gz2A:
undetectable		 2vcvB-4gz2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 7 GLY A 271
PHE A 159
CYH A 231
PHE A 230
 None
 0.99A 3ko0D-4gz2A:
undetectable
3ko0E-4gz2A:
undetectable		 3ko0D-4gz2A:
16.73
3ko0E-4gz2A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 7 CYH A 231
PHE A 230
GLY A 271
PHE A 159
 None
 0.96A 3ko0M-4gz2A:
undetectable
3ko0P-4gz2A:
undetectable		 3ko0M-4gz2A:
16.73
3ko0P-4gz2A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 8 GLY A 271
PHE A 159
CYH A 231
PHE A 230
 None
 0.98A 3ko0O-4gz2A:
undetectable
3ko0Q-4gz2A:
undetectable		 3ko0O-4gz2A:
16.73
3ko0Q-4gz2A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 8 ASP A 272
SER A 239
HIS A 236
ASP A 326
 None
 1.14A 3sg9B-4gz2A:
undetectable		 3sg9B-4gz2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 5 PHE A 269
PHE A 329
LEU A 342
PRO A 300
 None
 1.46A 4o8zA-4gz2A:
undetectable		 4o8zA-4gz2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 6 VAL A 221
LYS A 202
ILE A 181
LYS A 200
 None
 1.30A 5q1sA-4gz2A:
undetectable		 5q1sA-4gz2A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		5 / 12 LEU A 255
LEU A 286
GLY A 285
LEU A 275
ARG A 327
 None
None
None
None
FMT  A 401 ( 4.7A)
 1.19A 5uc1A-4gz2A:
undetectable		 5uc1A-4gz2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 5 ASN A 274
ASP A 272
ASN A 130
ASP A 132
 None
None
MG  A 402 ( 4.3A)
MG  A 402 (-2.9A)
 1.23A 5vooE-4gz2A:
undetectable		 5vooE-4gz2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		3 / 3 ASP A 272
ASN A 130
ASP A 132
 None
MG  A 402 ( 4.3A)
MG  A 402 (-2.9A)
 0.84A 5vopB-4gz2A:
2.1		 5vopB-4gz2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 8 ILE A 268
PHE A 291
LEU A 337
LEU A 297
 None
 0.85A 5y7pE-4gz2A:
undetectable		 5y7pE-4gz2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 8 LEU A 194
VAL A 199
VAL A 223
PHE A 230
 None
 0.72A 5y9mX-4gz2A:
undetectable		 5y9mX-4gz2A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		5 / 9 LEU A 194
VAL A 199
VAL A 223
ILE A 268
PHE A 230
 None
 0.92A 5yf9X-4gz2A:
undetectable		 5yf9X-4gz2A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2
(Mus
musculus) 		4 / 7 TRP A 307
HIS A 323
ARG A 247
GLU A 242
 None
 1.32A 6mn4F-4gz2A:
undetectable		 6mn4F-4gz2A:
22.22