SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 VAL A 354
TRP A 356
TRP A 402
 None
 1.45A 1c4dA-4gz7A:
undetectable
1c4dB-4gz7A:
undetectable		 1c4dA-4gz7A:
4.44
1c4dB-4gz7A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 HIS A  63
HIS A 188
HIS A 244
ASP A 322
 None
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.68A 1e9yB-4gz7A:
21.1		 1e9yB-4gz7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 6 HIS A  63
HIS A  65
HIS A 188
HIS A 244
ASP A 322
 None
MHA  A 601 (-3.8A)
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.67A 1fweC-4gz7A:
21.9		 1fweC-4gz7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 GLY A  11
ALA A  50
VAL A 435
VAL A 399
ILE A 401
 None
 1.07A 1hsgB-4gz7A:
undetectable		 1hsgB-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 9 ASP A 396
GLY A  58
ILE A  56
VAL A  25
ILE A  32
 None
 1.10A 1hxwA-4gz7A:
undetectable		 1hxwA-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.23A 2avoB-4gz7A:
undetectable		 2avoB-4gz7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.38A 2avoB-4gz7A:
undetectable		 2avoB-4gz7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.20A 2avvB-4gz7A:
undetectable		 2avvB-4gz7A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.33A 2avvB-4gz7A:
undetectable		 2avvB-4gz7A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.29A 2bpxB-4gz7A:
undetectable		 2bpxB-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.23A 2o4kB-4gz7A:
undetectable		 2o4kB-4gz7A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.34A 2o4kB-4gz7A:
undetectable		 2o4kB-4gz7A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.93A 2pymA-4gz7A:
undetectable		 2pymA-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.94A 2pymB-4gz7A:
undetectable		 2pymB-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.96A 2pynA-4gz7A:
undetectable		 2pynA-4gz7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.95A 2pynB-4gz7A:
undetectable		 2pynB-4gz7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 9 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.00A 2q5kA-4gz7A:
undetectable		 2q5kA-4gz7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A 397
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.95A 2q63B-4gz7A:
undetectable		 2q63B-4gz7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.20A 2r5pB-4gz7A:
undetectable		 2r5pB-4gz7A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.33A 2r5pB-4gz7A:
undetectable		 2r5pB-4gz7A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 LEU A 297
MET A 293
MET A 202
 None
MHA  A 601 (-4.3A)
None
 1.03A 2vavF-4gz7A:
undetectable		 2vavF-4gz7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 6 ARG A 408
ILE A 423
GLN A 290
GLU A 425
 None
 1.28A 2ya7C-4gz7A:
undetectable		 2ya7C-4gz7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.29A 2z54B-4gz7A:
undetectable		 2z54B-4gz7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.42A 2z54B-4gz7A:
undetectable		 2z54B-4gz7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 SER A 438
MET A  93
LEU A  87
LEU A 449
VAL A 451
 None
 1.11A 3dcjA-4gz7A:
undetectable
3dcjB-4gz7A:
undetectable		 3dcjA-4gz7A:
20.21
3dcjB-4gz7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  11
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.33A 3el1B-4gz7A:
undetectable		 3el1B-4gz7A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 12 GLY A  12
ALA A  50
ASP A  49
VAL A 435
VAL A 399
ILE A 401
 None
 1.48A 3el1B-4gz7A:
undetectable		 3el1B-4gz7A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		6 / 10 GLY A  12
ALA A  50
VAL A 435
LEU A   8
VAL A 399
ILE A 401
 None
 1.24A 3em3A-4gz7A:
undetectable		 3em3A-4gz7A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 GLU A 349
GLY A  90
THR A  91
 None
 0.58A 3iazA-4gz7A:
undetectable		 3iazA-4gz7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 8 GLY A  89
PHE A 382
PHE A 384
GLY A  58
 None
 0.89A 3ko0O-4gz7A:
undetectable
3ko0Q-4gz7A:
undetectable		 3ko0O-4gz7A:
11.25
3ko0Q-4gz7A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 7 GLY A  58
GLY A  89
PHE A 382
PHE A 384
 None
 0.94A 3ko0M-4gz7A:
undetectable
3ko0P-4gz7A:
undetectable		 3ko0M-4gz7A:
11.25
3ko0P-4gz7A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 6 GLU A 222
THR A 303
ALA A 250
ALA A 251
 None
 1.23A 3ns1C-4gz7A:
undetectable		 3ns1C-4gz7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.45A 3w9tA-4gz7A:
undetectable		 3w9tA-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.46A 3w9tB-4gz7A:
undetectable		 3w9tB-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 6 CYH A 324
THR A 325
ASN A 323
ASP A 322
 MHA  A 601 ( 4.1A)
None
None
MHA  A 601 (-2.0A)
 1.41A 3w9tB-4gz7A:
undetectable		 3w9tB-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.45A 3w9tC-4gz7A:
undetectable		 3w9tC-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.46A 3w9tD-4gz7A:
undetectable		 3w9tD-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.45A 3w9tE-4gz7A:
undetectable		 3w9tE-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.45A 3w9tF-4gz7A:
undetectable		 3w9tF-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 ASP A 398
VAL A 437
GLY A 440
ASP A 124
 None
 1.46A 3w9tG-4gz7A:
undetectable		 3w9tG-4gz7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 PHE A 370
GLY A  89
ILE A  56
VAL A 400
 None
 0.88A 3wrkA-4gz7A:
undetectable		 3wrkA-4gz7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 PHE A 370
GLY A  89
THR A 436
VAL A 400
 None
 1.01A 3wrkD-4gz7A:
undetectable		 3wrkD-4gz7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 HIS A  63
HIS A 188
HIS A 244
ASP A 322
 None
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.59A 4h9mA-4gz7A:
22.8		 4h9mA-4gz7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 TYR A 160
HIS A 213
ARG A 217
 MHA  A 602 (-4.0A)
MHA  A 603 (-3.1A)
MHA  A 603 (-4.0A)
 0.98A 4htfA-4gz7A:
undetectable		 4htfA-4gz7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 10 PHE A 370
GLY A  89
THR A 436
ILE A  56
VAL A 400
 None
 1.03A 4jx1B-4gz7A:
undetectable		 4jx1B-4gz7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 7 LEU A  54
VAL A  55
PRO A  57
GLU A 367
 None
 0.99A 4lb2A-4gz7A:
undetectable		 4lb2A-4gz7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 6 HIS A  63
HIS A  65
HIS A 188
HIS A 244
ASP A 322
 None
MHA  A 601 (-3.8A)
None
MHA  A 601 (-3.8A)
MHA  A 601 (-2.0A)
 0.63A 4ubpC-4gz7A:
21.9		 4ubpC-4gz7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 7 ASP A  61
ILE A  94
GLY A  82
THR A 321
 None
 1.05A 4zxiA-4gz7A:
undetectable		 4zxiA-4gz7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 6 GLU A 446
GLY A  58
ASP A 398
GLY A  90
 None
 0.83A 5cdnA-4gz7A:
undetectable
5cdnB-4gz7A:
undetectable		 5cdnA-4gz7A:
22.06
5cdnB-4gz7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 ALA A  88
ASP A 398
LYS A 388
GLY A  59
SER A 375
 None
 1.27A 5hfjE-4gz7A:
undetectable		 5hfjE-4gz7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 MET A 246
GLY A 274
TYR A 306
ILE A 423
ALA A 270
 None
 1.03A 5kvaA-4gz7A:
undetectable		 5kvaA-4gz7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		5 / 12 MET A 246
GLY A 274
TYR A 306
ILE A 423
ALA A 270
 None
 1.03A 5kvaB-4gz7A:
undetectable		 5kvaB-4gz7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 4 SER A 249
ALA A 250
GLN A 227
THR A 226
 None
 1.43A 5n0wA-4gz7A:
undetectable		 5n0wA-4gz7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		4 / 5 SER A 249
ALA A 250
GLN A 227
THR A 226
 None
 1.39A 5n4iA-4gz7A:
undetectable		 5n4iA-4gz7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4gz7 DIHYDROPYRIMIDINASE
(Tetraodon
nigroviridis) 		3 / 3 LYS A 120
PRO A 453
LYS A  84
 None
 1.21A 5y9yA-4gz7A:
undetectable		 5y9yA-4gz7A:
20.82