SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 6 ILE A 140
TRP A  93
ASP A  75
PRO A  94
 None
None
None
NAG  A 801 ( 4.3A)
 1.20A 1ditH-4gz8A:
undetectable
1ditP-4gz8A:
undetectable		 1ditH-4gz8A:
15.07
1ditP-4gz8A:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 10 PHE A 483
VAL A 482
VAL A 458
ILE A 434
LEU A 501
 None
 1.11A 1fe2A-4gz8A:
undetectable		 1fe2A-4gz8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 PHE A  78
SER A  54
ALA A  73
ILE A 118
 None
 1.00A 1fxhA-4gz8A:
undetectable
1fxhB-4gz8A:
undetectable		 1fxhA-4gz8A:
17.66
1fxhB-4gz8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 LEU A 313
ILE A 416
ILE A 434
ILE A 421
ILE A 451
 None
 1.06A 1oipA-4gz8A:
undetectable		 1oipA-4gz8A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 11 GLY A  50
SER A  54
PHE A  48
PHE A  78
HIS A  76
 CA  A 809 ( 4.8A)
None
None
None
NAG  A 801 (-4.2A)
 1.42A 1w76A-4gz8A:
undetectable		 1w76A-4gz8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 ARG A 100
GLU A 113
LYS A  74
PRO A 173
 None
 1.12A 2ejgA-4gz8A:
undetectable		 2ejgA-4gz8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 MET A 492
ALA A 491
VAL A 327
GLY A 504
ILE A 489
 None
 1.25A 3a65A-4gz8A:
undetectable		 3a65A-4gz8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 SER A  35
ILE A 489
ASN A  44
LEU A 512
LEU A 501
 None
None
ACT  A 810 (-3.5A)
None
None
 1.04A 3cjtG-4gz8A:
undetectable		 3cjtG-4gz8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 GLY A  50
GLY A  72
GLY A 508
LEU A  61
ILE A  77
 CA  A 809 ( 4.8A)
None
None
None
None
 0.95A 3elwA-4gz8A:
undetectable		 3elwA-4gz8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 ILE A 434
ILE A 421
ILE A 423
LEU A 459
VAL A 436
 None
 1.21A 3fpjB-4gz8A:
undetectable		 3fpjB-4gz8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		3 / 3 TYR A 534
ASP A 447
ASP A 437
 None
 0.73A 3r24A-4gz8A:
undetectable		 3r24A-4gz8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 8 GLN A 309
THR A 329
THR A 261
ARG A 248
 None
 0.96A 4k87A-4gz8A:
undetectable		 4k87A-4gz8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		6 / 12 GLY A 337
ASN A 428
ILE A 451
THR A 488
VAL A 340
ILE A 434
 None
 1.32A 4q5mA-4gz8A:
undetectable		 4q5mA-4gz8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 9 GLY A 508
ASN A  49
VAL A 482
VAL A  45
LEU A  40
 None
 1.15A 4qd3A-4gz8A:
undetectable		 4qd3A-4gz8A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 THR A 142
GLY A 133
ALA A 131
ILE A  77
 None
 0.95A 4txnA-4gz8A:
undetectable		 4txnA-4gz8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 THR A 142
GLY A 133
ALA A 131
ILE A  77
 None
 0.96A 4txnB-4gz8A:
undetectable		 4txnB-4gz8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 THR A 142
GLY A 133
ALA A 131
ILE A  77
 None
 0.95A 4txnC-4gz8A:
undetectable		 4txnC-4gz8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 THR A 213
GLY A 266
ARG A 264
PHE A 226
PRO A 224
 None
 1.21A 4uinH-4gz8A:
undetectable
4uinL-4gz8A:
undetectable		 4uinH-4gz8A:
17.97
4uinL-4gz8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		3 / 3 MET A 422
GLU A 474
LEU A 476
 None
 0.81A 4v2oB-4gz8A:
undetectable		 4v2oB-4gz8A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 6 TYR A  36
ILE A 503
VAL A  45
ALA A 510
 None
 0.86A 5cu6A-4gz8A:
undetectable		 5cu6A-4gz8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		3 / 3 PRO A 415
LEU A 308
SER A 294
 None
 0.70A 5fsaB-4gz8A:
undetectable		 5fsaB-4gz8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 4 ASN A  43
ILE A 503
TYR A 502
PHE A  88
 None
 1.33A 5igvA-4gz8A:
1.7		 5igvA-4gz8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		5 / 12 GLY A 167
GLY A 165
GLN A 215
ALA A 192
ASP A 193
 None
 1.21A 5x7fA-4gz8A:
undetectable		 5x7fA-4gz8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 8 VAL A 311
LEU A 308
TYR A 343
ILE A 265
 None
 0.90A 5y1yA-4gz8A:
undetectable		 5y1yA-4gz8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4gz8 SEMAPHORIN-3A
(Mus
musculus) 		4 / 7 VAL A 327
PRO A 420
ILE A 451
THR A 453
 None
 0.90A 6cduF-4gz8A:
undetectable
6cduG-4gz8A:
undetectable		 6cduF-4gz8A:
16.28
6cduG-4gz8A:
16.28