SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		3 / 3 TRP A 262
LEU A 272
LYS A 332
 None
 0.77A 1yajK-4gziA:
undetectable		 1yajK-4gziA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		5 / 10 LEU A 163
ALA A 244
ILE A 186
LEU A 248
ILE A 182
 None
 1.00A 1yi4A-4gziA:
undetectable		 1yi4A-4gziA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		4 / 6 TYR A  47
GLY A 261
PHE A 305
SER A 260
 None
None
BGC  A 401 (-3.8A)
None
 1.24A 2a3cB-4gziA:
8.0		 2a3cB-4gziA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		4 / 8 TYR A 201
GLU A 310
TYR A  58
GLY A  31
 BGC  A 401 (-4.2A)
BGC  A 402 (-2.8A)
BGC  A 402 (-3.5A)
BGC  A 402 ( 3.7A)
 1.07A 2ha4A-4gziA:
undetectable		 2ha4A-4gziA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		4 / 7 TYR A 201
GLU A 310
TYR A  58
GLY A  31
 BGC  A 401 (-4.2A)
BGC  A 402 (-2.8A)
BGC  A 402 (-3.5A)
BGC  A 402 ( 3.7A)
 1.09A 2ha4B-4gziA:
undetectable		 2ha4B-4gziA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		5 / 12 SER A 125
GLY A 122
LEU A 163
THR A 245
LEU A 196
 None
 0.84A 2nyuB-4gziA:
undetectable		 2nyuB-4gziA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		4 / 5 LEU A  68
ASP A  40
ALA A  67
ILE A  57
 None
 1.12A 2qhfA-4gziA:
undetectable		 2qhfA-4gziA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		5 / 12 LEU A 248
ILE A 182
ILE A 185
ILE A 186
PHE A 174
 None
 0.98A 2ygoA-4gziA:
undetectable		 2ygoA-4gziA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		3 / 3 TYR A 178
TYR A 159
GLY A 122
 None
 0.62A 3eteB-4gziA:
undetectable
3eteD-4gziA:
undetectable
3eteF-4gziA:
undetectable		 3eteB-4gziA:
23.57
3eteD-4gziA:
23.57
3eteF-4gziA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		3 / 3 LEU A 194
PRO A 195
LEU A 189
 None
 0.53A 3hcrA-4gziA:
undetectable		 3hcrA-4gziA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		3 / 3 THR A 164
ASN A 165
SER A 172
 None
 0.66A 4tvtA-4gziA:
undetectable		 4tvtA-4gziA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		4 / 7 ILE A 253
ILE A 182
SER A 155
LEU A 162
 None
 0.73A 5fukA-4gziA:
undetectable
5fukB-4gziA:
undetectable		 5fukA-4gziA:
22.88
5fukB-4gziA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		5 / 11 ILE A 185
LEU A 248
LEU A 189
ALA A 190
VAL A 119
 None
 1.13A 5ji0A-4gziA:
undetectable		 5ji0A-4gziA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE
(Solanum
tuberosum) 		5 / 12 ILE A 139
LEU A  87
VAL A 154
ASP A  78
GLY A 116
 None
 1.22A 5nnaB-4gziA:
0.9		 5nnaB-4gziA:
22.36