SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 8 ASP A 968
ASP A 556
THR A 964
TYR A 962
 None
 0.84A 1rmtD-4gzuA:
undetectable		 1rmtD-4gzuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 8 LEU A 780
SER A 782
LEU A 806
ASP A 783
 None
 0.88A 2j2pA-4gzuA:
undetectable
2j2pB-4gzuA:
undetectable		 2j2pA-4gzuA:
18.89
2j2pB-4gzuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 PHE A 759
LEU A 850
PHE A 824
ILE A 833
ALA A 828
 None
 1.25A 2v0mC-4gzuA:
undetectable		 2v0mC-4gzuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 8 ILE A 719
ARG A 631
LEU A 627
PHE A 592
 None
 0.88A 2vctB-4gzuA:
3.6		 2vctB-4gzuA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		3 / 3 SER A 919
THR A 909
PHE A 954
 None
 0.68A 2x91A-4gzuA:
undetectable		 2x91A-4gzuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		3 / 3 TYR A1013
GLU A 545
ASN A 931
 None
 0.88A 2y7hC-4gzuA:
undetectable		 2y7hC-4gzuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 558
ASP A 556
TYR A 674
 None
 0.82A 2yvlB-4gzuA:
undetectable		 2yvlB-4gzuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 7 LYS A 767
LEU A 773
GLN A 774
LEU A 821
 None
 0.94A 2zxwC-4gzuA:
4.4
2zxwJ-4gzuA:
undetectable		 2zxwC-4gzuA:
18.97
2zxwJ-4gzuA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gB-4gzuA:
undetectable		 3j6gB-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gD-4gzuA:
undetectable		 3j6gD-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gF-4gzuA:
undetectable		 3j6gF-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gH-4gzuA:
undetectable		 3j6gH-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gJ-4gzuA:
undetectable		 3j6gJ-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gL-4gzuA:
undetectable		 3j6gL-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gN-4gzuA:
undetectable		 3j6gN-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gP-4gzuA:
undetectable		 3j6gP-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 VAL A 912
LEU A 959
PHE A 960
GLN A 686
LEU A 675
 None
 1.35A 3j6gR-4gzuA:
undetectable		 3j6gR-4gzuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 GLU A 741
THR A 679
LEU A 682
GLN A 686
HIS A 925
 None
 1.46A 3kp3A-4gzuA:
0.1
3kp3B-4gzuA:
0.0		 3kp3A-4gzuA:
14.89
3kp3B-4gzuA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 7 SER A 796
GLY A 794
THR A 788
PHE A 798
 None
 1.05A 4ac9C-4gzuA:
undetectable		 4ac9C-4gzuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		3 / 3 TYR A 787
ARG A 801
SER A 789
 None
 1.17A 4dr2I-4gzuA:
undetectable
4dr2J-4gzuA:
undetectable		 4dr2I-4gzuA:
13.06
4dr2J-4gzuA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 5 GLU A 550
THR A 549
HIS A 701
LEU A 698
 None
 1.04A 5axaA-4gzuA:
undetectable		 5axaA-4gzuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 5 GLU A 550
THR A 549
HIS A 701
LEU A 698
 None
 1.05A 5axaC-4gzuA:
undetectable		 5axaC-4gzuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 GLY A 617
ASP A 537
ILE A 542
TYR A 702
 None
 1.00A 5iwuA-4gzuA:
undetectable		 5iwuA-4gzuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 GLU A 668
LEU A 675
ASP A 745
ASN A 678
LEU A 682
 None
 1.37A 5kc4E-4gzuA:
undetectable		 5kc4E-4gzuA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 GLU A 734
LEU A 977
ASP A 924
HIS A 925
PRO A 676
 None
 1.29A 5syeB-4gzuA:
undetectable		 5syeB-4gzuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 THR A 740
THR A 648
LEU A 568
ASN A 678
PHE A 564
 None
 1.49A 5ybbB-4gzuA:
undetectable		 5ybbB-4gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 VAL A 646
LEU A 736
LEU A 733
ARG A 732
 None
 0.99A 6e43A-4gzuA:
1.2		 6e43A-4gzuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 VAL A 646
LEU A 736
LEU A 733
ARG A 732
 None
 0.98A 6e43B-4gzuA:
3.3		 6e43B-4gzuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 VAL A 646
LEU A 736
LEU A 733
ARG A 732
 None
 0.98A 6e43D-4gzuA:
1.7		 6e43D-4gzuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 4 ARG A 732
GLN A 641
PHE A 640
LEU A 733
 None
 1.33A 6nmfC-4gzuA:
0.6		 6nmfC-4gzuA:
18.97