SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
6 / 9 ASP A 153
ASP A 184
ARG A 207
ARG A 222
ASP A 264
GLU A 265
None
0.69A 1nd4B-4h05A:
31.3
1nd4B-4h05A:
40.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 6 PRO A 173
ALA A 258
GLU A 254
GLU A 255
None
1.48A 1qhyA-4h05A:
undetectable
1qhyA-4h05A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 HIS A 182
ASP A 216
THR A 134
ASP A 184
None
1.21A 1rg9A-4h05A:
undetectable
1rg9A-4h05A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 HIS A 182
ASP A 216
THR A 134
ASP A 184
None
1.19A 1rg9B-4h05A:
undetectable
1rg9B-4h05A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 HIS A 182
ASP A 216
THR A 134
ASP A 184
None
1.21A 1rg9C-4h05A:
undetectable
1rg9C-4h05A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 LEU A 221
LEU A 257
LEU A 110
LEU A 185
CYH A 186
None
1.13A 1sqnB-4h05A:
undetectable
1sqnB-4h05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 MET A   1
ALA A  27
GLY A  49
VAL A  72
THR A  86
None
1.10A 3c6gB-4h05A:
undetectable
3c6gB-4h05A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 9 ALA A  94
LEU A 185
VAL A 220
SER A 116
PHE A 240
None
1.18A 3freX-4h05A:
undetectable
3freX-4h05A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
3 / 3 SER A 215
PHE A 259
LYS A 256
None
0.83A 3u88A-4h05A:
undetectable
3u88A-4h05A:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.46A 4feuA-4h05A:
29.5
4feuB-4h05A:
28.1
4feuA-4h05A:
34.03
4feuB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.49A 4feuB-4h05A:
28.1
4feuB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4feuD-4h05A:
28.8
4feuD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 204
ASP A 264
GLU A 265
None
0.88A 4feuD-4h05A:
28.8
4feuD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.44A 4feuF-4h05A:
28.7
4feuF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4fevB-4h05A:
28.9
4fevB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEV_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 10 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.42A 4fevC-4h05A:
30.1
4fevD-4h05A:
29.4
4fevE-4h05A:
29.2
4fevC-4h05A:
34.03
4fevD-4h05A:
34.03
4fevE-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.49A 4fevD-4h05A:
29.4
4fevD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.46A 4fevF-4h05A:
28.7
4fevF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEW_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.66A 4fewA-4h05A:
30.0
4fewD-4h05A:
29.5
4fewA-4h05A:
34.03
4fewD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.45A 4fewB-4h05A:
29.7
4fewB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.61A 4fewC-4h05A:
30.1
4fewD-4h05A:
29.5
4fewF-4h05A:
29.3
4fewC-4h05A:
34.03
4fewD-4h05A:
34.03
4fewF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.48A 4fewD-4h05A:
29.5
4fewD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.46A 4fewF-4h05A:
29.3
4fewF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4fexB-4h05A:
29.0
4fexB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEX_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 10 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.64A 4fexD-4h05A:
30.3
4fexD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FEX_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 9 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.73A 4fexE-4h05A:
30.3
4fexE-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.49A 4gkhB-4h05A:
29.3
4gkhB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.65A 4gkhC-4h05A:
30.0
4gkhD-4h05A:
29.6
4gkhC-4h05A:
34.03
4gkhD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4gkhD-4h05A:
29.6
4gkhD-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 10 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.64A 4gkhE-4h05A:
29.5
4gkhF-4h05A:
29.2
4gkhE-4h05A:
34.03
4gkhF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 8 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.69A 4gkhF-4h05A:
29.2
4gkhF-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 7 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.48A 4gkhG-4h05A:
28.6
4gkhG-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.66A 4gkhI-4h05A:
29.7
4gkhJ-4h05A:
29.6
4gkhI-4h05A:
34.03
4gkhJ-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 6 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4gkhJ-4h05A:
29.6
4gkhJ-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.45A 4gkhC-4h05A:
30.0
4gkhK-4h05A:
28.6
4gkhC-4h05A:
34.03
4gkhK-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.49A 4gkiA-4h05A:
29.3
4gkiA-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.66A 4gkiA-4h05A:
29.3
4gkiB-4h05A:
29.9
4gkiA-4h05A:
34.03
4gkiB-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.47A 4gkiC-4h05A:
28.8
4gkiC-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 10 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.65A 4gkiE-4h05A:
29.5
4gkiE-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
4 / 8 ASP A 153
ASP A 184
ASP A 264
GLU A 265
None
0.45A 4gkiE-4h05A:
29.5
4gkiG-4h05A:
28.8
4gkiE-4h05A:
34.03
4gkiG-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 9 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.68A 4gkiJ-4h05A:
29.4
4gkiJ-4h05A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GKI_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 ASP A 153
ASP A 184
ARG A 207
ASP A 264
GLU A 265
None
0.65A 4gkiK-4h05A:
29.7
4gkiL-4h05A:
29.8
4gkiK-4h05A:
34.03
4gkiL-4h05A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 LEU A  59
VAL A 205
LEU A  32
LEU A   8
TYR A  12
None
1.43A 4o8fB-4h05A:
undetectable
4o8fB-4h05A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 LEU A 202
LEU A  62
LEU A 113
VAL A 180
LEU A 120
None
1.14A 4p65C-4h05A:
undetectable
4p65D-4h05A:
undetectable
4p65J-4h05A:
undetectable
4p65L-4h05A:
undetectable
4p65C-4h05A:
4.95
4p65D-4h05A:
8.44
4p65J-4h05A:
8.44
4p65L-4h05A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 LEU A 113
VAL A 180
LEU A 120
LEU A 202
LEU A  62
None
1.10A 4p65B-4h05A:
undetectable
4p65D-4h05A:
undetectable
4p65G-4h05A:
undetectable
4p65H-4h05A:
undetectable
4p65B-4h05A:
8.44
4p65D-4h05A:
8.44
4p65G-4h05A:
4.95
4p65H-4h05A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 12 TYR A 260
ASP A 212
PHE A 259
VAL A 135
LEU A 178
None
1.24A 5b8iC-4h05A:
undetectable
5b8iC-4h05A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus)
5 / 11 TYR A 260
ASP A 212
PHE A 259
VAL A 135
LEU A 178
None
1.31A 5huaA-4h05A:
undetectable
5huaA-4h05A:
16.00