SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A  59
VAL A  61
TRP A  34
GLY A  72
 None
 1.04A 1ng8A-4h08A:
undetectable		 1ng8A-4h08A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A  59
VAL A  61
TRP A  34
GLY A  72
 None
 1.04A 1ng8B-4h08A:
undetectable		 1ng8B-4h08A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A  54
VAL A 213
VAL A  46
ILE A 101
VAL A 100
 None
 1.10A 2qboA-4h08A:
undetectable		 2qboA-4h08A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 160
VAL A 163
ARG A 164
ILE A 167
 None
 0.48A 2yfbA-4h08A:
undetectable		 2yfbA-4h08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 160
VAL A 163
ARG A 164
ILE A 167
 None
 0.64A 2yfbB-4h08A:
undetectable		 2yfbB-4h08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 177
ASN A  51
ILE A 101
ALA A 135
VAL A 220
 None
UNL  A 301 ( 3.5A)
None
None
None
 1.21A 3a51E-4h08A:
undetectable		 3a51E-4h08A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  53
ARG A 146
THR A 158
LEU A 161
 None
 0.97A 3ag1N-4h08A:
undetectable
3ag1W-4h08A:
undetectable		 3ag1N-4h08A:
16.50
3ag1W-4h08A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A 143
VAL A 145
GLY A 198
ASP A 197
ILE A  53
 None
 1.11A 3bf1A-4h08A:
2.1
3bf1B-4h08A:
undetectable		 3bf1A-4h08A:
19.69
3bf1B-4h08A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 8 ASN A 105
THR A 142
LEU A 161
HIS A 108
ASN A  76
 None
None
None
UNL  A 301 ( 3.8A)
None
 1.45A 3kp2A-4h08A:
undetectable
3kp2B-4h08A:
undetectable		 3kp2A-4h08A:
22.93
3kp2B-4h08A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP4_A_MIIA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 9 ASN A 105
THR A 142
LEU A 161
HIS A 108
ASN A  76
 None
None
None
UNL  A 301 ( 3.8A)
None
 1.44A 3kp4A-4h08A:
undetectable
3kp4B-4h08A:
undetectable		 3kp4A-4h08A:
22.93
3kp4B-4h08A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 125
SER A  31
TRP A  30
ALA A  84
LEU A  85
 None
 1.41A 3lw5B-4h08A:
undetectable		 3lw5B-4h08A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 200
GLU A  26
ASP A  82
ASN A 105
 UNL  A 301 ( 4.7A)
None
None
None
 1.31A 3vywA-4h08A:
2.9		 3vywA-4h08A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 LYS A  78
LEU A  85
GLU A  88
LEU A  89
 None
 1.43A 4k4yE-4h08A:
undetectable		 4k4yE-4h08A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4h08 PUTATIVE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 9 VAL A 216
ILE A 217
LEU A  65
ILE A 138
GLY A  72
 None
 1.13A 4kukA-4h08A:
undetectable		 4kukA-4h08A:
22.60