SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 342
GLY A 331
LEU A 228
VAL A 304
 None
 1.07A 1gsfA-4h0aA:
undetectable		 1gsfA-4h0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 342
GLY A 331
LEU A 228
VAL A 304
 None
 1.07A 1gsfB-4h0aA:
undetectable		 1gsfB-4h0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 342
GLY A 331
LEU A 228
VAL A 304
 None
 1.07A 1gsfD-4h0aA:
undetectable		 1gsfD-4h0aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 8 GLN A 295
ASN A 296
LEU A 340
LEU A 307
 None
 1.17A 1hk2A-4h0aA:
undetectable		 1hk2A-4h0aA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLY A  64
GLY A  62
THR A  65
GLU A  61
ILE A 175
 None
 0.87A 2oxtB-4h0aA:
undetectable		 2oxtB-4h0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLY A  64
GLY A  62
THR A  65
GLU A  61
ILE A 175
 None
 0.92A 2oxtC-4h0aA:
undetectable		 2oxtC-4h0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 7 LEU A 189
SER A 190
TYR A 116
THR A 118
 None
 1.04A 2uz2A-4h0aA:
undetectable		 2uz2A-4h0aA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 8 TYR A 116
THR A 235
LEU A 322
MET A 312
 None
 1.31A 3wipG-4h0aA:
undetectable
3wipH-4h0aA:
undetectable		 3wipG-4h0aA:
21.79
3wipH-4h0aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 4 VAL A 113
THR A 107
GLU A 111
GLU A 110
 None
 1.40A 4l78A-4h0aA:
undetectable		 4l78A-4h0aA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 7 GLN A 227
TYR A  91
SER A 106
ASN A  93
 None
None
EDO  A 401 (-3.4A)
EDO  A 401 (-3.2A)
 1.14A 4ws0A-4h0aA:
undetectable		 4ws0A-4h0aA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4h0a UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 7 SER A 106
TYR A  91
PHE A  87
HIS A 216
 EDO  A 401 (-3.4A)
None
EDO  A 401 ( 4.6A)
None
 1.42A 5dlvB-4h0aA:
undetectable		 5dlvB-4h0aA:
18.73