SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 GLU A  48
TYR A 290
PHE A 179
 None
 0.95A 1eqbB-4h0fA:
undetectable		 1eqbB-4h0fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 GLU A  48
TYR A 290
PHE A 179
 None
 0.96A 1eqbA-4h0fA:
undetectable		 1eqbA-4h0fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 GLU A  48
TYR A 290
PHE A 179
 None
 0.96A 1eqbD-4h0fA:
undetectable		 1eqbD-4h0fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 GLU A  48
TYR A 290
PHE A 179
 None
 0.97A 1eqbC-4h0fA:
undetectable		 1eqbC-4h0fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 8 MET A  42
ALA A 154
PHE A 179
ILE A 157
 None
 1.01A 1gm7A-4h0fA:
undetectable
1gm7B-4h0fA:
undetectable		 1gm7A-4h0fA:
22.55
1gm7B-4h0fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASP A 140
GLU A 153
ARG A  96
 None
 0.84A 1wopA-4h0fA:
undetectable		 1wopA-4h0fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		5 / 12 HIS A  66
ASP A 140
LEU A 118
PHE A  39
MET A  42
 ZN  A 401 (-3.1A)
None
None
None
None
 1.48A 1xmuB-4h0fA:
undetectable		 1xmuB-4h0fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		5 / 12 HIS A  66
ASP A 140
LEU A 118
PHE A  39
MET A  42
 ZN  A 401 (-3.1A)
None
None
None
None
 1.48A 1xomA-4h0fA:
undetectable		 1xomA-4h0fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 5 ASP A 140
GLY A 222
PRO A 228
ILE A 226
 None
 0.93A 2aoiA-4h0fA:
undetectable		 2aoiA-4h0fA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 5 PHE A 209
PHE A 202
LEU A 218
PHE A 194
 None
 1.37A 2y69C-4h0fA:
undetectable
2y69J-4h0fA:
undetectable		 2y69C-4h0fA:
19.66
2y69J-4h0fA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 5 PHE A 209
PHE A 202
LEU A 218
PHE A 194
 None
 1.35A 3abmC-4h0fA:
undetectable
3abmJ-4h0fA:
undetectable		 3abmC-4h0fA:
19.66
3abmJ-4h0fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 5 PHE A 209
PHE A 202
LEU A 218
PHE A 194
 None
 1.32A 3abmP-4h0fA:
undetectable
3abmW-4h0fA:
undetectable		 3abmP-4h0fA:
19.66
3abmW-4h0fA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 7 ASN A 108
LEU A  83
ASP A  82
LYS A  32
 None
 1.43A 3lslA-4h0fA:
undetectable
3lslD-4h0fA:
undetectable		 3lslA-4h0fA:
24.11
3lslD-4h0fA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 HIS A 142
HIS A  66
HIS A 206
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.1A)
ZN  A 401 (-3.4A)
 0.49A 3qpkA-4h0fA:
undetectable		 3qpkA-4h0fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 HIS A 142
HIS A  66
HIS A 206
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.1A)
ZN  A 401 (-3.4A)
 0.49A 3qpkB-4h0fA:
undetectable		 3qpkB-4h0fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASP A  55
ARG A  57
ASP A  52
 None
 0.87A 4fp9A-4h0fA:
undetectable		 4fp9A-4h0fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 7 LEU A  83
VAL A  36
TYR A 172
GLU A 160
 None
 0.94A 4lb2A-4h0fA:
undetectable		 4lb2A-4h0fA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 6 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.44A 4w5qA-4h0fA:
2.1		 4w5qA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 6 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.47A 4w5rA-4h0fA:
undetectable		 4w5rA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 6 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.47A 4w5tA-4h0fA:
2.1		 4w5tA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 6 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.46A 4z4fA-4h0fA:
2.0		 4z4fA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 5 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.50A 4z4hA-4h0fA:
2.0		 4z4hA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		4 / 6 ASP A 140
ALA A 208
THR A 145
TYR A 211
 None
ZN  A 401 ( 4.0A)
None
None
 1.48A 4z4iA-4h0fA:
2.1		 4z4iA-4h0fA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		3 / 3 HIS A 142
HIS A  66
HIS A 206
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.1A)
ZN  A 401 (-3.4A)
 0.45A 5migA-4h0fA:
undetectable		 5migA-4h0fA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		5 / 12 HIS A 206
ALA A 208
SER A 210
PRO A 141
LEU A  91
 ZN  A 401 (-3.4A)
ZN  A 401 ( 4.0A)
None
None
None
 1.18A 5syfB-4h0fA:
undetectable		 5syfB-4h0fA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4h0f LAMININ-BINDING
SURFACE PROTEIN
(Streptococcus
agalactiae) 		5 / 12 GLU A 111
GLU A 281
HIS A 206
SER A 227
GLY A  64
 None
ZN  A 401 (-2.2A)
ZN  A 401 (-3.4A)
None
None
 1.49A 5xioA-4h0fA:
undetectable		 5xioA-4h0fA:
21.16