SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus;
Synechococcus
elongatus) 		3 / 3 ASP B 101
THR B   6
GLU A 109
 None
 0.79A 1pj7A-4h0mB:
undetectable		 1pj7A-4h0mB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 12 THR B  40
TYR B 163
PHE A  31
LEU B  30
ALA B 102
 CYC  B 202 ( 4.7A)
None
None
None
None
 1.34A 1q23A-4h0mB:
undetectable
1q23B-4h0mB:
undetectable		 1q23A-4h0mB:
24.68
1q23B-4h0mB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		4 / 6 LEU A  24
VAL B  52
ILE B  44
ARG B  84
 CYC  B 202 ( 4.6A)
None
None
CYC  B 201 (-2.8A)
 1.02A 2hyyA-4h0mA:
undetectable		 2hyyA-4h0mA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		4 / 6 ASP A  13
ARG B 108
ASP B 107
THR B   1
 None
 1.29A 2j2pE-4h0mA:
undetectable
2j2pF-4h0mA:
undetectable		 2j2pE-4h0mA:
21.97
2j2pF-4h0mA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4h0m C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 12 LEU B 105
ASP B 165
GLY B 161
VAL B 131
ALA B 168
 None
 1.37A 2kceA-4h0mB:
undetectable		 2kceA-4h0mB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4h0m C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		4 / 7 LEU B  90
VAL B  93
THR B  94
VAL B 142
 None
None
None
CYC  B 202 (-4.2A)
 0.93A 2qblA-4h0mB:
undetectable		 2qblA-4h0mB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 12 LEU B  30
ILE A  94
LEU B  19
VAL B   8
LEU A  38
 None
 1.00A 3gwxB-4h0mB:
undetectable		 3gwxB-4h0mB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
(Synechococcus
elongatus) 		3 / 3 ASP A 148
ARG A 147
ARG A  32
 None
 1.05A 3k37A-4h0mA:
undetectable		 3k37A-4h0mA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
(Synechococcus
elongatus) 		3 / 3 PRO A 106
THR A 104
LEU A 112
 None
 0.78A 3ttrA-4h0mA:
undetectable		 3ttrA-4h0mA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 11 THR B   6
GLN A  33
GLY A 105
THR A 104
ALA A  98
 None
 1.18A 5bxnH-4h0mB:
undetectable
5bxnI-4h0mB:
undetectable		 5bxnH-4h0mB:
22.09
5bxnI-4h0mB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 11 THR B   6
GLN A  33
GLY A 105
THR A 104
ALA A  98
 None
 1.17A 5bxnV-4h0mB:
undetectable
5bxnW-4h0mB:
undetectable		 5bxnV-4h0mB:
22.09
5bxnW-4h0mB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4h0m C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 11 THR B   1
ALA B   4
GLY B 100
ASP B 106
LEU B 110
 None
 1.06A 5lf7H-4h0mB:
undetectable
5lf7I-4h0mB:
undetectable		 5lf7H-4h0mB:
25.11
5lf7I-4h0mB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4h0m C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus) 		5 / 11 THR B   1
ALA B   4
GLY B 100
ASP B 106
LEU B 110
 None
 1.08A 5lf7V-4h0mB:
undetectable
5lf7W-4h0mB:
undetectable		 5lf7V-4h0mB:
25.11
5lf7W-4h0mB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
(Synechococcus
elongatus) 		5 / 12 SER A  50
VAL A  52
ALA A  58
ALA A  55
GLY A  54
 None
 1.33A 5tzoC-4h0mA:
undetectable		 5tzoC-4h0mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus;
Synechococcus
elongatus) 		5 / 12 ALA A  10
LYS A   1
ALA A  12
ARG B  91
TYR B  92
 None
 1.14A 5zvgA-4h0mA:
undetectable		 5zvgA-4h0mA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechococcus
elongatus;
Synechococcus
elongatus) 		5 / 12 ALA A  10
LYS A   1
ALA A  12
ARG B  91
TYR B  92
 None
 1.13A 5zvgB-4h0mA:
undetectable		 5zvgB-4h0mA:
17.45