SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4h0n DNMT2
(Spodoptera
frugiperda) 		5 / 12 GLY A  11
GLY A  14
ILE A  56
PRO A  77
VAL A 318
 SAH  A 401 (-3.3A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.2A)
SAH  A 401 (-4.4A)
 0.68A 2hmyB-4h0nA:
26.5		 2hmyB-4h0nA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		3 / 3 LEU A 301
PRO A 302
ARG A 312
 None
 0.66A 2qd5A-4h0nA:
undetectable		 2qd5A-4h0nA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 8 SER A 125
PHE A 122
PHE A  81
ASN A  96
 None
 1.23A 2wekA-4h0nA:
5.0		 2wekA-4h0nA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4h0n DNMT2
(Spodoptera
frugiperda) 		5 / 12 GLY A  11
GLY A  14
PRO A  77
ASN A 316
VAL A 318
 SAH  A 401 (-3.3A)
SAH  A 401 (-3.7A)
SAH  A 401 (-4.2A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.4A)
 0.78A 3av6A-4h0nA:
15.7		 3av6A-4h0nA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 8 SER A 229
ILE A 197
LEU A 194
ASN A 156
 None
 0.87A 3dcjB-4h0nA:
5.3		 3dcjB-4h0nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 5 ASP A 106
LEU A 105
ILE A  64
PRO A  61
 CA  A 402 (-2.5A)
None
None
None
 1.15A 3s3vA-4h0nA:
undetectable		 3s3vA-4h0nA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 5 GLY A  13
ILE A  12
VAL A 320
SER A 317
 SAH  A 401 ( 4.4A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-2.6A)
 1.03A 4d33A-4h0nA:
undetectable		 4d33A-4h0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 5 GLY A  13
ILE A  12
VAL A 320
SER A 317
 SAH  A 401 ( 4.4A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-2.6A)
 1.03A 4d33B-4h0nA:
undetectable		 4d33B-4h0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4h0n DNMT2
(Spodoptera
frugiperda) 		4 / 6 GLY A  13
ILE A  12
VAL A 320
SER A 317
 SAH  A 401 ( 4.4A)
SAH  A 401 (-4.3A)
None
SAH  A 401 (-2.6A)
 1.02A 4d39B-4h0nA:
undetectable		 4d39B-4h0nA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		6 / 12 GLY A  14
GLY A  13
GLY A  11
LEU A  73
ALA A  18
VAL A 318
 SAH  A 401 (-3.7A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
None
None
SAH  A 401 (-4.4A)
 1.18A 4htfA-4h0nA:
8.2		 4htfA-4h0nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		6 / 12 GLY A  14
GLY A  13
GLY A  11
LEU A  73
ALA A  18
VAL A 318
 SAH  A 401 (-3.7A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
None
None
SAH  A 401 (-4.4A)
 1.12A 4htfB-4h0nA:
8.1		 4htfB-4h0nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4h0n DNMT2
(Spodoptera
frugiperda) 		5 / 12 LEU A 326
LEU A  24
HIS A   3
THR A  71
ILE A   5
 None
 1.21A 4okbA-4h0nA:
undetectable		 4okbA-4h0nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		5 / 12 GLY A  11
ASP A  33
ILE A  34
ASN A  35
PRO A  77
 SAH  A 401 (-3.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.7A)
SAH  A 401 (-4.2A)
 0.69A 4rtsA-4h0nA:
5.2		 4rtsA-4h0nA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4h0n DNMT2
(Spodoptera
frugiperda) 		3 / 3 PRO A 302
ILE A 197
SER A  40
 None
 0.81A 5fsaA-4h0nA:
undetectable		 5fsaA-4h0nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4h0n DNMT2
(Spodoptera
frugiperda) 		3 / 3 GLY A  11
ASP A  33
ASN A  55
 SAH  A 401 (-3.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.6A)
 0.25A 5jglA-4h0nA:
9.4		 5jglA-4h0nA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4h0n DNMT2
(Spodoptera
frugiperda) 		6 / 12 GLY A  11
GLY A  14
ILE A  56
ASN A 316
SER A 317
VAL A 318
 SAH  A 401 (-3.3A)
SAH  A 401 (-3.7A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.6A)
SAH  A 401 (-4.4A)
 0.59A 6mhtA-4h0nA:
26.4		 6mhtA-4h0nA:
28.42