SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 10 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.94A 1sdtA-4h0oA:
undetectable		 1sdtA-4h0oA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 11 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.88A 1t3rB-4h0oA:
undetectable		 1t3rB-4h0oA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 9 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.87A 2avoA-4h0oA:
undetectable		 2avoA-4h0oA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 9 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.95A 2o4pB-4h0oA:
undetectable		 2o4pB-4h0oA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.91A 3cywA-4h0oA:
undetectable		 3cywA-4h0oA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.91A 3d1xB-4h0oA:
undetectable		 3d1xB-4h0oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 9 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.98A 3d1yB-4h0oA:
undetectable		 3d1yB-4h0oA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 4 GLY A 234
VAL A 228
GLY A 202
THR A 201
 None
 0.94A 3ib2A-4h0oA:
undetectable		 3ib2A-4h0oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 5 VAL A 179
LEU A 183
ILE A 194
ALA A 196
 None
 1.00A 3n8yB-4h0oA:
undetectable		 3n8yB-4h0oA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 6 ALA A  65
ILE A 127
VAL A  82
HIS A  84
 None
 1.18A 3nneG-4h0oA:
undetectable		 3nneG-4h0oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 10 ASN A 376
ALA A 374
LEU A 317
LEU A 183
VAL A 179
 None
 1.24A 3o02A-4h0oA:
undetectable
3o02B-4h0oA:
undetectable		 3o02A-4h0oA:
22.89
3o02B-4h0oA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.90A 4dqbA-4h0oA:
undetectable		 4dqbA-4h0oA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 11 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.94A 4dqeA-4h0oA:
undetectable		 4dqeA-4h0oA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 11 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.88A 4dqhA-4h0oA:
undetectable		 4dqhA-4h0oA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 8 GLU A 378
HIS A 198
GLY A 203
SER A 204
 None
 0.98A 4f93B-4h0oA:
undetectable		 4f93B-4h0oA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.92A 4hlaA-4h0oA:
undetectable		 4hlaA-4h0oA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 11 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.88A 4hlaB-4h0oA:
undetectable		 4hlaB-4h0oA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 SER A 182
LEU A 183
TYR A 178
GLY A 325
LEU A 326
 None
 1.19A 4j7xB-4h0oA:
2.7		 4j7xB-4h0oA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 9 VAL A 331
ILE A 335
LEU A 318
ILE A 298
GLY A 306
 None
 0.76A 4kukA-4h0oA:
undetectable		 4kukA-4h0oA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 10 CYH A 197
CYH A 206
LEU A 227
LEU A 199
HIS A 172
 None
 1.22A 4p65A-4h0oA:
undetectable
4p65B-4h0oA:
undetectable
4p65F-4h0oA:
undetectable
4p65H-4h0oA:
undetectable		 4p65A-4h0oA:
3.98
4p65B-4h0oA:
6.88
4p65F-4h0oA:
6.88
4p65H-4h0oA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 11 CYH A 197
CYH A 206
LEU A 227
LEU A 199
HIS A 172
 None
 1.06A 4p65E-4h0oA:
undetectable
4p65F-4h0oA:
undetectable
4p65J-4h0oA:
undetectable
4p65L-4h0oA:
undetectable		 4p65E-4h0oA:
3.98
4p65F-4h0oA:
6.88
4p65J-4h0oA:
6.88
4p65L-4h0oA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 SER A 175
PHE A 215
THR A 148
THR A 217
LEU A 308
 None
 1.46A 4z7fC-4h0oA:
undetectable		 4z7fC-4h0oA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 12 THR A 223
GLY A 170
GLY A 220
ALA A 144
HIS A 146
 None
 0.97A 5c0oF-4h0oA:
undetectable		 5c0oF-4h0oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 5 CYH A 197
CYH A 206
LEU A 199
HIS A 172
 None
 1.07A 5hrqA-4h0oA:
undetectable
5hrqB-4h0oA:
undetectable
5hrqF-4h0oA:
undetectable		 5hrqA-4h0oA:
3.98
5hrqB-4h0oA:
7.77
5hrqF-4h0oA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 5 CYH A 197
CYH A 206
LEU A 199
HIS A 172
 None
 1.05A 5hrqC-4h0oA:
undetectable
5hrqD-4h0oA:
undetectable
5hrqL-4h0oA:
undetectable		 5hrqC-4h0oA:
3.98
5hrqD-4h0oA:
7.77
5hrqL-4h0oA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 6 HIS A 172
CYH A 197
CYH A 206
LEU A 199
 None
 1.11A 5hrqB-4h0oA:
undetectable
5hrqI-4h0oA:
undetectable
5hrqJ-4h0oA:
undetectable		 5hrqB-4h0oA:
7.77
5hrqI-4h0oA:
3.98
5hrqJ-4h0oA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 6 HIS A 172
CYH A 197
CYH A 206
LEU A 199
 None
 1.15A 5hrqH-4h0oA:
undetectable
5hrqK-4h0oA:
undetectable
5hrqL-4h0oA:
undetectable		 5hrqH-4h0oA:
7.77
5hrqK-4h0oA:
3.98
5hrqL-4h0oA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		5 / 9 LEU A 183
GLY A 208
ILE A 195
VAL A 179
ILE A 180
 None
 0.99A 5kr2D-4h0oA:
undetectable		 5kr2D-4h0oA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4h0o ACETATE KINASE
(Entamoeba
histolytica) 		4 / 5 THR A 321
THR A 217
HIS A 146
GLY A 203
 None
 1.18A 6gbnC-4h0oA:
undetectable		 6gbnC-4h0oA:
21.96