SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 355
LEU A 407
LEU A 377
VAL A 373
ALA A 219
 None
 1.19A 1gseA-4h0pA:
undetectable		 1gseA-4h0pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 8 GLY A 104
ILE A 111
LEU A 156
ASP A 108
 None
 0.92A 1jg4A-4h0pA:
undetectable		 1jg4A-4h0pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 11 SER A 225
SER A 226
ARG A 253
THR A 238
GLY A 193
 None
 1.28A 1jr1A-4h0pA:
undetectable		 1jr1A-4h0pA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		3 / 3 SER A 223
GLY A 224
ARG A 100
 None
 0.62A 1t9wA-4h0pA:
undetectable		 1t9wA-4h0pA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 TYR A  96
CYH A  98
VAL A  76
ILE A  94
LEU A  79
 None
 1.34A 1z9hA-4h0pA:
undetectable		 1z9hA-4h0pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 TYR A  96
CYH A  98
VAL A  76
ILE A  94
LEU A  79
 None
 1.35A 1z9hB-4h0pA:
undetectable		 1z9hB-4h0pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 TYR A  96
CYH A  98
VAL A  76
ILE A  94
LEU A  79
 None
 1.34A 1z9hC-4h0pA:
undetectable		 1z9hC-4h0pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 298
ALA A 297
GLY A 250
GLY A 251
ILE A 305
 None
 0.81A 2avvD-4h0pA:
undetectable		 2avvD-4h0pA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  83
LEU A  79
GLY A  20
ALA A  10
ALA A 421
 None
 1.08A 2bm9F-4h0pA:
undetectable		 2bm9F-4h0pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  83
GLY A  20
ASP A 415
ALA A  10
ALA A 421
 None
 1.16A 2br4E-4h0pA:
undetectable		 2br4E-4h0pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 298
ALA A 297
GLY A 250
GLY A 251
ILE A 305
 None
 0.82A 2fxeA-4h0pA:
undetectable		 2fxeA-4h0pA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 6 ARG A 164
GLY A 105
PRO A 185
THR A 183
 None
 0.92A 2m2oB-4h0pA:
undetectable		 2m2oB-4h0pA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		3 / 3 SER A 198
GLU A 364
ASP A 415
 None
 0.78A 2zthA-4h0pA:
undetectable		 2zthA-4h0pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 9 LEU A 221
ILE A 362
GLY A 361
SER A 226
LEU A 248
 None
 1.13A 3ai9X-4h0pA:
undetectable		 3ai9X-4h0pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		3 / 3 SER A 198
GLU A 364
ASP A 415
 None
 0.84A 3bwmA-4h0pA:
undetectable		 3bwmA-4h0pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 8 SER A 235
ASP A 159
CYH A 228
ASP A 237
 None
 1.27A 3havA-4h0pA:
undetectable		 3havA-4h0pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 5 ILE A 146
HIS A 152
VAL A  97
HIS A  99
 None
 1.34A 3nneA-4h0pA:
undetectable		 3nneA-4h0pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 5 ILE A 146
HIS A 152
VAL A  97
HIS A  99
 None
 1.33A 3nneB-4h0pA:
0.0		 3nneB-4h0pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 9 GLY A 381
ALA A 382
GLY A 355
ILE A 353
LEU A 377
 None
 0.94A 3ogpB-4h0pA:
undetectable		 3ogpB-4h0pA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 5 SER A  16
GLY A 361
GLU A 413
GLU A 364
 None
 1.16A 3raeB-4h0pA:
undetectable
3raeD-4h0pA:
undetectable		 3raeB-4h0pA:
24.31
3raeD-4h0pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 6 LEU A 287
SER A 291
ALA A 295
LEU A 245
 None
 1.00A 3ravA-4h0pA:
undetectable		 3ravA-4h0pA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 6 THR A  37
ASN A  38
GLY A  67
ILE A  78
 None
 1.03A 3w9tF-4h0pA:
undetectable		 3w9tF-4h0pA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 7 PHE A 162
TYR A 196
VAL A 200
ILE A 214
 None
 1.13A 4a97H-4h0pA:
undetectable		 4a97H-4h0pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 355
ILE A 350
VAL A 337
LEU A 377
VAL A 373
 None
 1.04A 4gc9A-4h0pA:
undetectable		 4gc9A-4h0pA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		3 / 3 SER A 198
GLU A 364
ASP A 415
 None
 0.84A 4xudA-4h0pA:
undetectable		 4xudA-4h0pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 11 LEU A 296
LEU A 324
LEU A 334
LEU A 248
LEU A 249
 None
 1.00A 4zowA-4h0pA:
undetectable		 4zowA-4h0pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 10 LEU A 248
GLY A 250
GLY A 292
LEU A 333
VAL A 328
 None
 1.05A 5o96G-4h0pA:
undetectable
5o96H-4h0pA:
undetectable		 5o96G-4h0pA:
19.82
5o96H-4h0pA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 HIS A  99
VAL A  97
LEU A  22
LEU A  79
ILE A  18
 None
 1.49A 5xprA-4h0pA:
undetectable		 5xprA-4h0pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 10 GLY A 251
GLY A 292
SER A 223
THR A 300
ASN A 301
 None
 1.15A 6exiA-4h0pA:
undetectable		 6exiA-4h0pA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 251
GLY A 292
SER A 223
THR A 300
ASN A 301
 None
 1.13A 6exiC-4h0pA:
undetectable
6exiD-4h0pA:
undetectable		 6exiC-4h0pA:
11.29
6exiD-4h0pA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 251
GLY A 292
SER A 223
THR A 300
ASN A 301
 None
 1.13A 6exiC-4h0pA:
undetectable
6exiD-4h0pA:
undetectable		 6exiC-4h0pA:
11.29
6exiD-4h0pA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 8 ILE A  18
ALA A 138
ARG A 137
ASP A 277
 None
 1.04A 6hu9a-4h0pA:
undetectable
6hu9e-4h0pA:
0.4		 6hu9a-4h0pA:
23.03
6hu9e-4h0pA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4h0p ACETATE KINASE
(Cryptococcus
neoformans) 		4 / 6 ILE A  18
ALA A 138
ARG A 137
ASP A 277
 None
 1.00A 6hu9m-4h0pA:
undetectable
6hu9q-4h0pA:
undetectable		 6hu9m-4h0pA:
23.03
6hu9q-4h0pA:
14.22