SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 6 THR A 200
ASP A 225
THR A 226
ASP A 206
 None
 1.22A 2okcB-4h14A:
undetectable		 2okcB-4h14A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		5 / 12 LEU A 155
VAL A 140
THR A 224
VAL A 229
PHE A 104
 None
 1.41A 2y00B-4h14A:
undetectable		 2y00B-4h14A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		5 / 12 LEU A 155
VAL A 140
THR A 224
VAL A 229
PHE A 104
 None
 1.41A 2y01B-4h14A:
undetectable		 2y01B-4h14A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 7 TYR A  50
THR A 266
TYR A 213
TYR A  67
 None
 1.38A 3wipA-4h14A:
undetectable
3wipB-4h14A:
undetectable		 3wipA-4h14A:
20.81
3wipB-4h14A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 7 TYR A  50
THR A 266
TYR A 213
TYR A  67
 None
 1.37A 3wipF-4h14A:
undetectable
3wipG-4h14A:
undetectable		 3wipF-4h14A:
20.81
3wipG-4h14A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		5 / 10 THR A 230
ALA A 105
ILE A 125
VAL A 140
ALA A 221
 None
 1.01A 4lbgA-4h14A:
undetectable		 4lbgA-4h14A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		5 / 9 THR A 230
ALA A 105
ILE A 125
VAL A 140
ALA A 221
 None
 1.06A 4lbgB-4h14A:
undetectable		 4lbgB-4h14A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 6 VAL A 191
VAL A 139
SER A 137
PHE A 219
 None
 1.08A 5jw1B-4h14A:
undetectable		 5jw1B-4h14A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 7 HIS A 143
LEU A 155
VAL A 139
SER A 158
 NAG  A1005 ( 4.1A)
None
None
None
 1.01A 5m8rA-4h14A:
undetectable		 5m8rA-4h14A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 8 HIS A 143
LEU A 155
VAL A 139
SER A 158
 NAG  A1005 ( 4.1A)
None
None
None
 1.00A 5m8rB-4h14A:
undetectable		 5m8rB-4h14A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		4 / 8 HIS A 143
LEU A 155
VAL A 139
SER A 158
 NAG  A1005 ( 4.1A)
None
None
None
 1.00A 5m8rD-4h14A:
undetectable		 5m8rD-4h14A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4h14 SPIKE GLYCOPROTEIN
(Betacoronavirus
1) 		5 / 12 PHE A 199
VAL A 107
PHE A  99
PHE A 219
PHE A 122
 None
 1.42A 6becA-4h14A:
undetectable
6becB-4h14A:
undetectable
6becC-4h14A:
undetectable		 6becA-4h14A:
19.00
6becB-4h14A:
19.00
6becC-4h14A:
19.00