SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.77A 1a7yA-4h16A:
undetectable		 1a7yA-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.80A 1a7yB-4h16A:
undetectable		 1a7yB-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 116
GLY A  86
GLY A  85
ALA A 112
LEU A  57
 None
P6G  A 305 ( 3.7A)
P6G  A 305 (-4.9A)
None
None
 0.97A 1bx4A-4h16A:
5.7		 1bx4A-4h16A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 LEU A 144
LEU A 142
THR A 255
ILE A 218
ILE A 211
 None
None
None
None
P6G  A 305 ( 4.9A)
 1.27A 1hzeA-4h16A:
undetectable
1hzeB-4h16A:
undetectable		 1hzeA-4h16A:
17.51
1hzeB-4h16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ILE A 211
LEU A 144
LEU A 142
THR A 255
ILE A 218
 P6G  A 305 ( 4.9A)
None
None
None
None
 1.27A 1hzeA-4h16A:
undetectable
1hzeB-4h16A:
undetectable		 1hzeA-4h16A:
17.51
1hzeB-4h16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 148
PRO A 145
THR A 149
 P6G  A 305 ( 4.5A)
None
None
 0.78A 1i3wE-4h16A:
undetectable		 1i3wE-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.80A 1i3wF-4h16A:
undetectable		 1i3wF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 148
PRO A 145
THR A 149
 P6G  A 305 ( 4.5A)
None
None
 0.81A 1i3wG-4h16A:
undetectable		 1i3wG-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.86A 1i3wG-4h16A:
undetectable		 1i3wG-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.80A 1mnvD-4h16A:
undetectable		 1mnvD-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 148
PRO A 145
THR A 149
 P6G  A 305 ( 4.5A)
None
None
 0.88A 1ovfB-4h16A:
undetectable		 1ovfB-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.78A 1qfiA-4h16A:
undetectable		 1qfiA-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.83A 1qfiB-4h16A:
undetectable		 1qfiB-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 148
PRO A 145
THR A 149
 P6G  A 305 ( 4.5A)
None
None
 0.85A 1unjF-4h16A:
undetectable		 1unjF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.79A 1unjF-4h16A:
undetectable		 1unjF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.85A 1unjR-4h16A:
undetectable		 1unjR-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 148
PRO A 145
THR A 149
 P6G  A 305 ( 4.5A)
None
None
 0.85A 1unmF-4h16A:
undetectable		 1unmF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.80A 1unmF-4h16A:
undetectable		 1unmF-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 VAL A  66
THR A  58
THR A  70
ARG A  73
 None
 1.14A 3bjwA-4h16A:
undetectable		 3bjwA-4h16A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 VAL A  66
THR A  58
THR A  70
ARG A  73
 None
 1.14A 3bjwC-4h16A:
undetectable		 3bjwC-4h16A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A  52
LEU A  51
ARG A  73
ILE A  14
LEU A  30
 None
 1.02A 3nrrA-4h16A:
undetectable		 3nrrA-4h16A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A  52
LEU A  51
ARG A  73
ILE A  14
LEU A  30
 None
 0.94A 3nrrB-4h16A:
undetectable		 3nrrB-4h16A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 237
VAL A  81
ILE A 233
ALA A  12
VAL A  79
 None
 1.01A 3t3cB-4h16A:
undetectable		 3t3cB-4h16A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4jksA-4h16A:
5.8		 4jksA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4jksB-4h16A:
5.9		 4jksB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.01A 4jkuA-4h16A:
6.3		 4jkuA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.01A 4k8cA-4h16A:
6.4		 4k8cA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4k8cB-4h16A:
5.8		 4k8cB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4k8kA-4h16A:
5.7		 4k8kA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4kahA-4h16A:
6.1		 4kahA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4kahB-4h16A:
5.8		 4kahB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4kalA-4h16A:
5.8		 4kalA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.01A 4kalB-4h16A:
5.7		 4kalB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 0.99A 4kanA-4h16A:
6.4		 4kanA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 0.99A 4kanB-4h16A:
5.8		 4kanB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.02A 4kbeA-4h16A:
6.2		 4kbeA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 0.97A 4kbeB-4h16A:
2.4		 4kbeB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.01A 4lbgA-4h16A:
5.8		 4lbgA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 1.00A 4lbgB-4h16A:
5.9		 4lbgB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 0.99A 4lcaA-4h16A:
5.9		 4lcaA-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 218
GLY A 254
GLY A 253
ILE A 138
THR A 250
 None
 0.98A 4lcaB-4h16A:
5.9		 4lcaB-4h16A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A 215
GLY A 216
ILE A 138
GLN A 139
 None
None
None
P6G  A 305 (-3.9A)
 1.12A 4ma8C-4h16A:
undetectable		 4ma8C-4h16A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  79
LEU A   7
VAL A 133
ILE A 233
LEU A   5
 None
 1.02A 4y8wC-4h16A:
undetectable		 4y8wC-4h16A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 217
ASP A 213
GLY A 221
SER A 189
 None
 1.03A 4z53A-4h16A:
2.7
4z53B-4h16A:
undetectable		 4z53A-4h16A:
16.60
4z53B-4h16A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 ILE A 184
PRO A 226
ILE A  14
VAL A  81
 None
 1.01A 4zj8A-4h16A:
2.5		 4zj8A-4h16A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A 226
VAL A 229
ILE A 233
ALA A 234
ILE A 184
 None
 0.78A 5j2tC-4h16A:
7.2		 5j2tC-4h16A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 SER A 166
LYS A 167
SER A 170
 CL  A 303 (-2.7A)
None
CL  A 303 ( 4.5A)
 0.75A 6az3P-4h16A:
undetectable		 6az3P-4h16A:
17.93