SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4h18 CMT1
(Corynebacterium
glutamicum) 		3 / 3 TRP A  60
ALA A 114
VAL A 118
 None
 0.96A 1bdwA-4h18A:
undetectable
1bdwB-4h18A:
undetectable		 1bdwA-4h18A:
5.41
1bdwB-4h18A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 8 TYR A 206
LEU A 173
LEU A 165
LEU A 169
 None
 0.65A 1e7cA-4h18A:
undetectable		 1e7cA-4h18A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 TRP A 161
GLY A 110
GLY A 111
LEU A 105
PRO A 137
 None
 1.11A 1qzzA-4h18A:
undetectable		 1qzzA-4h18A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 10 ALA A 192
THR A 194
HIS A 201
GLU A 162
ALA A 255
 None
 1.22A 1r55A-4h18A:
undetectable		 1r55A-4h18A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.45A 2eikN-4h18A:
undetectable
2eikP-4h18A:
undetectable		 2eikN-4h18A:
21.69
2eikP-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.44A 2eilN-4h18A:
undetectable
2eilP-4h18A:
undetectable		 2eilN-4h18A:
21.69
2eilP-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 5 ALA A  92
ILE A  90
ASN A 133
ILE A 102
 None
 1.07A 2h4jA-4h18A:
undetectable		 2h4jA-4h18A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 PHE A 198
GLY A 108
THR A 194
GLY A 156
LEU A 155
 None
 1.03A 2hw2A-4h18A:
undetectable		 2hw2A-4h18A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 6 LEU A 256
VAL A 269
ILE A 329
ARG A 183
 None
 0.99A 2hyyA-4h18A:
undetectable		 2hyyA-4h18A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 ASP A 207
PHE A 361
PRO A 100
THR A 179
 None
 1.30A 2q6kA-4h18A:
2.7		 2q6kA-4h18A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 PHE A 142
SER A 195
LEU A 275
ALA A 216
THR A 218
 None
 1.25A 2v0mC-4h18A:
undetectable		 2v0mC-4h18A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4h18 CMT1
(Corynebacterium
glutamicum) 		6 / 12 ILE A 251
GLY A 243
GLY A 246
ASN A 152
LEU A 155
ASN A 253
 None
 1.44A 2y7hB-4h18A:
undetectable		 2y7hB-4h18A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4h18 CMT1
(Corynebacterium
glutamicum) 		6 / 12 ILE A 251
GLY A 243
GLY A 247
ASN A 152
LEU A 155
ASN A 253
 None
 1.40A 2y7hB-4h18A:
undetectable		 2y7hB-4h18A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.44A 3ag3A-4h18A:
undetectable
3ag3C-4h18A:
undetectable		 3ag3A-4h18A:
21.69
3ag3C-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.43A 3ag3N-4h18A:
undetectable
3ag3P-4h18A:
undetectable		 3ag3N-4h18A:
21.69
3ag3P-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.45A 3ag4N-4h18A:
undetectable
3ag4P-4h18A:
undetectable		 3ag4N-4h18A:
21.69
3ag4P-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4h18 CMT1
(Corynebacterium
glutamicum) 		3 / 3 SER A 220
ASP A 254
ASN A 258
 None
 0.95A 3lslA-4h18A:
undetectable
3lslD-4h18A:
undetectable		 3lslA-4h18A:
20.42
3lslD-4h18A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 ALA A 186
ALA A 192
THR A 193
LEU A 196
LEU A 256
 None
 1.11A 3r9cA-4h18A:
undetectable		 3r9cA-4h18A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 GLY A 277
GLY A 274
SER A 273
ASP A 109
 None
 0.77A 5ergB-4h18A:
undetectable		 5ergB-4h18A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		3 / 3 LYS A 141
ASP A 109
ARG A 233
 None
 1.09A 5jwaA-4h18A:
undetectable
5jwaH-4h18A:
undetectable		 5jwaA-4h18A:
19.02
5jwaH-4h18A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4h18 CMT1
(Corynebacterium
glutamicum) 		3 / 3 THR A 340
SER A 342
ASP A 349
 None
 0.86A 5kvaB-4h18A:
undetectable		 5kvaB-4h18A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 THR A 146
GLN A 159
ARG A 233
GLY A 234
LEU A 231
 None
 1.41A 5m50B-4h18A:
3.4		 5m50B-4h18A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4h18 CMT1
(Corynebacterium
glutamicum) 		5 / 12 LYS A 130
PHE A 126
ALA A 208
ILE A 102
PRO A 100
 None
 1.46A 5mlmA-4h18A:
undetectable		 5mlmA-4h18A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.42A 5x1fN-4h18A:
undetectable
5x1fP-4h18A:
undetectable		 5x1fN-4h18A:
21.69
5x1fP-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.39A 6nmfN-4h18A:
undetectable
6nmfP-4h18A:
undetectable		 6nmfN-4h18A:
21.69
6nmfP-4h18A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h18 CMT1
(Corynebacterium
glutamicum) 		4 / 7 TRP A 117
ASP A 125
TYR A 127
TRP A 346
 None
 1.39A 6nmpN-4h18A:
undetectable
6nmpP-4h18A:
undetectable		 6nmpN-4h18A:
21.69
6nmpP-4h18A:
20.78