SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 9 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.37A 1i00B-4h1xA:
undetectable		 1i00B-4h1xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 8 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.39A 1rtsA-4h1xA:
undetectable		 1rtsA-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.45A 1rtsB-4h1xA:
undetectable		 1rtsB-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 5 ILE A 151
LEU A 195
ALA A 254
GLU A 167
 None
 1.10A 1xvaA-4h1xA:
undetectable
1xvaB-4h1xA:
undetectable		 1xvaA-4h1xA:
22.47
1xvaB-4h1xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 165
ALA A 254
ALA A 252
LEU A 195
VAL A 192
 None
 1.11A 2bxeB-4h1xA:
undetectable		 2bxeB-4h1xA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 8 SER A 237
ARG A 238
LEU A 240
GLU A 244
 None
 0.71A 2cdqA-4h1xA:
undetectable		 2cdqA-4h1xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 SER A 237
ARG A 238
LEU A 240
GLU A 244
 None
 0.79A 2cdqB-4h1xA:
undetectable		 2cdqB-4h1xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.41A 2tsrA-4h1xA:
undetectable		 2tsrA-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 9 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.37A 2tsrD-4h1xA:
undetectable		 2tsrD-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 6 ILE A  97
SER A 101
LEU A 102
THR A 103
 None
 0.83A 3deuB-4h1xA:
undetectable		 3deuB-4h1xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 GLY A  95
VAL A  87
ILE A  37
VAL A 279
 None
 0.89A 3fi0E-4h1xA:
undetectable		 3fi0E-4h1xA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 SER A  46
GLY A  47
THR A  48
 CIT  A 302 (-2.5A)
CIT  A 302 (-3.2A)
CIT  A 302 (-3.3A)
 0.08A 3k9wA-4h1xA:
undetectable		 3k9wA-4h1xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		6 / 10 VAL A 260
PHE A  52
ILE A  94
ALA A  74
VAL A  83
VAL A  87
 None
 1.34A 3me6A-4h1xA:
undetectable		 3me6A-4h1xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		6 / 9 VAL A 260
PHE A  52
ILE A  94
ALA A  74
VAL A  83
VAL A  87
 None
 1.34A 3me6C-4h1xA:
undetectable		 3me6C-4h1xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		6 / 9 VAL A 260
PHE A  52
ILE A  94
ALA A  74
VAL A  83
VAL A  87
 None
 1.43A 3me6D-4h1xA:
undetectable		 3me6D-4h1xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 VAL A 261
VAL A 279
ILE A 111
ARG A  42
 None
None
None
CIT  A 302 (-3.1A)
 1.27A 3ms9B-4h1xA:
undetectable		 3ms9B-4h1xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 ILE A 223
VAL A 236
ARG A 238
 None
 0.75A 3p73A-4h1xA:
undetectable		 3p73A-4h1xA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		6 / 12 ILE A  58
VAL A  87
PHE A 280
ILE A 111
LEU A 109
VAL A 262
 None
 1.29A 3w68B-4h1xA:
undetectable		 3w68B-4h1xA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 GLU A 110
GLY A 113
SER A 269
 None
 0.71A 4b53B-4h1xA:
undetectable		 4b53B-4h1xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 9 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.40A 4eb4C-4h1xA:
undetectable		 4eb4C-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.44A 4eb4D-4h1xA:
undetectable		 4eb4D-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.59A 4iqqB-4h1xA:
undetectable		 4iqqB-4h1xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.59A 4iqqC-4h1xA:
undetectable		 4iqqC-4h1xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 PRO A 131
ASN A 133
HIS A 250
 None
 1.02A 4ma3H-4h1xA:
undetectable
4ma3L-4h1xA:
undetectable		 4ma3H-4h1xA:
24.82
4ma3L-4h1xA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 9 PHE A 165
ALA A 254
ALA A 252
LEU A 195
VAL A 192
 None
 0.88A 4or0A-4h1xA:
undetectable		 4or0A-4h1xA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 SER A  41
TYR A  96
ASP A  68
 None
 0.81A 4rp8C-4h1xA:
undetectable		 4rp8C-4h1xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.47A 5h3aB-4h1xA:
undetectable		 5h3aB-4h1xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		3 / 3 SER A  98
SER A 101
PHE A 132
 None
 0.96A 5mugA-4h1xA:
undetectable		 5mugA-4h1xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.46A 5nooA-4h1xA:
undetectable		 5nooA-4h1xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.59A 5nooB-4h1xA:
undetectable		 5nooB-4h1xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.38A 5x5qC-4h1xA:
undetectable		 5x5qC-4h1xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 8 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.36A 5x5qD-4h1xA:
undetectable		 5x5qD-4h1xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		5 / 6 PHE A 150
ILE A 151
ASP A 232
LEU A 184
GLY A 144
 None
 1.39A 5x5qE-4h1xA:
undetectable		 5x5qE-4h1xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 8 ILE A 212
LEU A 143
GLY A 144
PHE A 147
 None
 0.36A 5x5qF-4h1xA:
undetectable		 5x5qF-4h1xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2
(Streptococcus
pneumoniae) 		4 / 7 SER A 193
PHE A 165
GLY A  47
VAL A  83
 None
None
CIT  A 302 (-3.2A)
None
 0.83A 6dwnB-4h1xA:
undetectable		 6dwnB-4h1xA:
14.62