SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	4h20	HEAVY CHAIN OF FAB FRAGMENT FROM THE ANTI-RICIN MONOCLONAL ANTIBODY RAC18 (Mus musculus)	3 / 3	TYR H 181 GLY H 150 PHE H 152	None	0.72A	2m2pB-4h20H: undetectable	2m2pB-4h20H: 6.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M7K_H_ACTH302_0 (10H10 HEAVY CHAIN)	4h20	HEAVY CHAIN OF FAB FRAGMENT FROM THE ANTI-RICIN MONOCLONAL ANTIBODY RAC18 (Mus musculus)	4 / 5	VAL H 2 TYR H 27 ARG H 98 TYR H 108	None	0.34A	4m7kH-4h20H: 15.7	4m7kH-4h20H: 66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODI_G_ACTG702_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	4h20	HEAVY CHAIN OF FAB FRAGMENT FROM THE ANTI-RICIN MONOCLONAL ANTIBODY RAC18 (Mus musculus)	3 / 3	GLY H 66 THR H 69 ASN H 84	None	0.68A	5odiG-4h20H: undetectable	5odiG-4h20H: 14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TIW_B_OAQB302_0 (SULFOTRANSFERASE)	4h20	HEAVY CHAIN OF FAB FRAGMENT FROM THE ANTI-RICIN MONOCLONAL ANTIBODY RAC18 (Mus musculus)	5 / 12	ILE H 199 LEU H 158 VAL H 169 SER H 185 THR H 190	None	1.33A	5tiwB-4h20H: undetectable	5tiwB-4h20H: 23.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M2P_B_DHIB24_0","INSULIN B CHAIN","4h20","HEAVY CHAIN OF FAB FRAGMENT FROM THE  ANTI-RICIN MONOCLONAL ANTIBODY RAC18","Mus musculus",3,"TYR H 181;GLY H 150;PHE H 152","None","0.72A","2m2pB-4h20H:undetectable","2m2pB-4h20H:6.82"],["4M7K_H_ACTH302_0","10H10 HEAVY CHAIN","4h20","HEAVY CHAIN OF FAB FRAGMENT FROM THE  ANTI-RICIN MONOCLONAL ANTIBODY RAC18","Mus musculus",4,"VAL H   2;TYR H  27;ARG H  98;TYR H 108","None","0.34A","4m7kH-4h20H:15.7","4m7kH-4h20H:66.22"],["5ODI_G_ACTG702_0","HETERODISULFIDE REDUCTASE, SUBUNIT A","4h20","HEAVY CHAIN OF FAB FRAGMENT FROM THE  ANTI-RICIN MONOCLONAL ANTIBODY RAC18","Mus musculus",3,"GLY H  66;THR H  69;ASN H  84","None","0.68A","5odiG-4h20H:undetectable","5odiG-4h20H:14.62"],["5TIW_B_OAQB302_0","SULFOTRANSFERASE","4h20","HEAVY CHAIN OF FAB FRAGMENT FROM THE  ANTI-RICIN MONOCLONAL ANTIBODY RAC18","Mus musculus",5,"ILE H 199;LEU H 158;VAL H 169;SER H 185;THR H 190","None","1.33A","5tiwB-4h20H:undetectable","5tiwB-4h20H:23.16"]]