SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.18A 1c9sN-4h27A:
undetectable
1c9sO-4h27A:
undetectable		 1c9sN-4h27A:
13.46
1c9sO-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.21A 1c9sQ-4h27A:
undetectable
1c9sR-4h27A:
undetectable		 1c9sQ-4h27A:
13.46
1c9sR-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.12A 1gtfD-4h27A:
undetectable
1gtfE-4h27A:
undetectable		 1gtfD-4h27A:
13.46
1gtfE-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 1gtfJ-4h27A:
undetectable
1gtfK-4h27A:
undetectable		 1gtfJ-4h27A:
13.46
1gtfK-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.20A 1gtfR-4h27A:
undetectable
1gtfS-4h27A:
undetectable		 1gtfR-4h27A:
13.46
1gtfS-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 197
ALA A 220
GLY A 168
ALA A 269
HIS A 199
 None
None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
 1.02A 1gtnL-4h27A:
undetectable
1gtnV-4h27A:
undetectable		 1gtnL-4h27A:
13.46
1gtnV-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.15A 1utdE-4h27A:
undetectable
1utdF-4h27A:
undetectable		 1utdE-4h27A:
13.46
1utdF-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.15A 1utdH-4h27A:
undetectable
1utdI-4h27A:
undetectable		 1utdH-4h27A:
13.46
1utdI-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.96A 1utdL-4h27A:
undetectable
1utdM-4h27A:
undetectable		 1utdL-4h27A:
13.46
1utdM-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.97A 1utdO-4h27A:
undetectable
1utdP-4h27A:
undetectable		 1utdO-4h27A:
13.46
1utdP-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.96A 1utdP-4h27A:
undetectable
1utdQ-4h27A:
undetectable		 1utdP-4h27A:
13.46
1utdQ-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.18A 1utdU-4h27A:
undetectable
1utdV-4h27A:
undetectable		 1utdU-4h27A:
13.46
1utdV-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 PHE A  60
HIS A  59
ILE A 133
THR A  84
ALA A 104
 None
 1.28A 2gl0B-4h27A:
undetectable
2gl0C-4h27A:
undetectable		 2gl0B-4h27A:
17.86
2gl0C-4h27A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 PHE A  60
HIS A  59
ILE A 133
THR A  84
ALA A 104
 None
 1.34A 2gl0D-4h27A:
undetectable
2gl0E-4h27A:
undetectable		 2gl0D-4h27A:
17.86
2gl0E-4h27A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 PHE A  60
HIS A  59
ILE A 133
THR A  84
ALA A 104
 None
 1.36A 2gl0E-4h27A:
undetectable
2gl0F-4h27A:
undetectable		 2gl0E-4h27A:
17.86
2gl0F-4h27A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 273
GLY A 271
ALA A 251
LEU A 165
LEU A 285
 None
 0.95A 2nyuA-4h27A:
2.1		 2nyuA-4h27A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 273
GLY A 271
ALA A 251
LEU A 165
LEU A 291
 None
 0.89A 2nyuA-4h27A:
2.1		 2nyuA-4h27A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 273
GLY A 271
ALA A 251
LEU A 165
VAL A  27
 None
 0.97A 2nyuA-4h27A:
2.1		 2nyuA-4h27A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 LEU A 173
VAL A 167
GLY A 168
GLY A 175
ALA A 232
 None
LLP  A  41 ( 4.1A)
LLP  A  41 ( 3.5A)
None
None
 0.94A 2v3kA-4h27A:
undetectable		 2v3kA-4h27A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 273
ILE A 191
ILE A 255
GLU A 256
ALA A 253
 None
 1.15A 3axtA-4h27A:
4.4		 3axtA-4h27A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 305
GLY A 304
LEU A 265
SER A 309
ALA A 222
 LLP  A  41 ( 3.9A)
LLP  A  41 ( 4.6A)
None
None
LLP  A  41 ( 3.7A)
 1.19A 3i5uB-4h27A:
2.7		 3i5uB-4h27A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ARG A  43
SER A 297
THR A  25
ILE A 301
ASP A  32
 None
 1.16A 3lcvB-4h27A:
undetectable		 3lcvB-4h27A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 VAL A 167
PHE A 236
ALA A 203
THR A 206
VAL A 245
 LLP  A  41 ( 4.1A)
None
None
None
None
 1.07A 3me6C-4h27A:
undetectable		 3me6C-4h27A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ILE A 282
GLY A  24
ALA A  23
SER A  20
LEU A  19
 None
 1.12A 3n8xB-4h27A:
undetectable		 3n8xB-4h27A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A 161
LEU A 298
LEU A 295
ILE A 282
 None
 0.92A 3nbqB-4h27A:
undetectable		 3nbqB-4h27A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		4 / 8 ALA A  23
GLY A  24
THR A  25
GLN A 283
 None
 0.70A 3rglA-4h27A:
undetectable		 3rglA-4h27A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
 None
 1.07A 4dt8A-4h27A:
undetectable		 4dt8A-4h27A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ALA A 315
PRO A 268
ILE A 255
LEU A 265
ILE A 308
 None
 1.11A 4dtaA-4h27A:
undetectable		 4dtaA-4h27A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 TRP A  52
ILE A  42
ALA A  75
LEU A  79
ALA A  53
 None
LLP  A  41 ( 4.0A)
None
None
None
 1.35A 4fe1B-4h27A:
undetectable		 4fe1B-4h27A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 7 ILE A 133
PRO A 134
GLY A 171
ALA A  68
GLN A 178
 None
SO4  A 403 (-4.7A)
LLP  A  41 ( 3.2A)
SO4  A 402 (-3.3A)
None
 1.47A 4g0uB-4h27A:
undetectable		 4g0uB-4h27A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ALA A  18
LEU A  19
VAL A 300
ALA A 276
ALA A 254
 None
 1.08A 4j14A-4h27A:
undetectable		 4j14A-4h27A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 168
ALA A 198
LEU A 223
HIS A 199
 None
LLP  A  41 ( 3.5A)
None
None
None
 1.14A 4l8fB-4h27A:
undetectable		 4l8fB-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 169
ALA A 198
GLU A 194
HIS A 199
 None
LLP  A  41 ( 3.7A)
None
None
None
 1.18A 4l8fB-4h27A:
undetectable		 4l8fB-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 168
ALA A 198
LEU A 223
HIS A 199
 None
LLP  A  41 ( 3.5A)
None
None
None
 1.18A 4l8fD-4h27A:
undetectable		 4l8fD-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		3 / 3 GLU A 244
THR A 206
HIS A 202
 None
 0.82A 4ydqB-4h27A:
undetectable		 4ydqB-4h27A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
GLY A 170
GLY A 171
LEU A 172
GLU A 194
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.3A)
LLP  A  41 ( 3.2A)
LLP  A  41 ( 4.9A)
None
 0.99A 5c0oF-4h27A:
3.0		 5c0oF-4h27A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eevA-4h27A:
undetectable
5eevB-4h27A:
undetectable		 5eevA-4h27A:
13.46
5eevB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eewA-4h27A:
undetectable
5eewB-4h27A:
undetectable		 5eewA-4h27A:
13.46
5eewB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eexA-4h27A:
undetectable
5eexB-4h27A:
undetectable		 5eexA-4h27A:
13.46
5eexB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eeyA-4h27A:
undetectable
5eeyB-4h27A:
undetectable		 5eeyA-4h27A:
13.46
5eeyB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eezA-4h27A:
undetectable
5eezB-4h27A:
undetectable		 5eezA-4h27A:
13.46
5eezB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef0A-4h27A:
undetectable
5ef0B-4h27A:
undetectable		 5ef0A-4h27A:
13.46
5ef0B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef1A-4h27A:
undetectable
5ef1B-4h27A:
undetectable		 5ef1A-4h27A:
13.46
5ef1B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef2A-4h27A:
undetectable
5ef2B-4h27A:
undetectable		 5ef2A-4h27A:
13.46
5ef2B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.15A 5ef3A-4h27A:
undetectable
5ef3B-4h27A:
undetectable		 5ef3A-4h27A:
13.46
5ef3B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 269
GLY A 305
SER A 306
GLY A 224
LEU A 172
 LLP  A  41 ( 3.6A)
LLP  A  41 ( 3.9A)
None
None
LLP  A  41 ( 4.9A)
 1.12A 5gwxA-4h27A:
2.9		 5gwxA-4h27A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		4 / 5 CYH A 270
ILE A 301
CYH A 303
LEU A 274
 None
None
LLP  A  41 ( 3.2A)
None
 1.44A 5hrqC-4h27A:
undetectable
5hrqD-4h27A:
undetectable
5hrqL-4h27A:
undetectable		 5hrqC-4h27A:
4.63
5hrqD-4h27A:
7.98
5hrqL-4h27A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ILE A 282
ILE A 148
VAL A 177
LEU A 180
VAL A 149
 None
 0.79A 5mueA-4h27A:
undetectable		 5mueA-4h27A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
 1.01A 6dlzA-4h27A:
undetectable
6dlzD-4h27A:
undetectable		 6dlzA-4h27A:
13.57
6dlzD-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
 1.01A 6dlzB-4h27A:
undetectable
6dlzC-4h27A:
undetectable		 6dlzB-4h27A:
13.57
6dlzC-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
 1.00A 6dm1A-4h27A:
undetectable
6dm1D-4h27A:
undetectable		 6dm1A-4h27A:
13.57
6dm1D-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
 1.01A 6dm1B-4h27A:
undetectable
6dm1C-4h27A:
undetectable		 6dm1B-4h27A:
13.57
6dm1C-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A  80
LEU A  79
ALA A  53
LYS A  54
 None
 0.62A 6mdqA-4h27A:
undetectable		 6mdqA-4h27A:
11.75