SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 ARG A 167
ALA A 166
ASP A 172
GLY A 194
 None
 1.16A 1e7bA-4h2hA:
undetectable		 1e7bA-4h2hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 LEU A 353
GLY A  47
ALA A 106
GLY A 271
LEU A 272
 None
 1.11A 1fe2A-4h2hA:
undetectable		 1fe2A-4h2hA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 4 VAL A  52
TRP A  28
TRP A 295
 0XW  A 403 ( 4.6A)
None
None
 1.38A 1gmkC-4h2hA:
undetectable
1gmkD-4h2hA:
undetectable		 1gmkC-4h2hA:
3.88
1gmkD-4h2hA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 ALA A 327
VAL A  15
TRP A 295
 None
 0.86A 1kqeA-4h2hA:
undetectable
1kqeE-4h2hA:
undetectable		 1kqeA-4h2hA:
3.02
1kqeE-4h2hA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 ALA A 327
VAL A  15
TRP A 295
 None
 0.85A 1kqeB-4h2hA:
undetectable
1kqeD-4h2hA:
undetectable		 1kqeB-4h2hA:
3.02
1kqeD-4h2hA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 TRP A 295
ALA A 327
VAL A  15
 None
 0.87A 1kqeB-4h2hA:
undetectable
1kqeD-4h2hA:
undetectable		 1kqeB-4h2hA:
3.02
1kqeD-4h2hA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 TRP A 295
ALA A 327
VAL A  15
 None
 0.86A 1kqeA-4h2hA:
undetectable
1kqeE-4h2hA:
undetectable		 1kqeA-4h2hA:
3.02
1kqeE-4h2hA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 11 LEU A  85
VAL A 107
ILE A  37
LEU A  92
LEU A  71
 None
 1.22A 1mrqA-4h2hA:
4.2		 1mrqA-4h2hA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 ALA A 192
PHE A 215
ILE A 173
ASP A 172
 None
 1.12A 1yc2D-4h2hA:
undetectable		 1yc2D-4h2hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 11 TRP A 320
TYR A 325
TYR A  56
SER A  24
ASP A 241
 0XW  A 403 (-4.0A)
None
0XW  A 403 (-4.7A)
None
MG  A 401 ( 3.1A)
 1.13A 2bueA-4h2hA:
0.4		 2bueA-4h2hA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 ARG A 314
VAL A 131
THR A 128
 None
 0.62A 2nmzA-4h2hA:
undetectable		 2nmzA-4h2hA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 7 PHE A 206
MET A 217
PHE A 215
ILE A 173
 None
 1.18A 2zseA-4h2hA:
undetectable		 2zseA-4h2hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 SER A 267
LEU A 321
GLY A 296
CYH A 304
 None
 1.04A 3aiaA-4h2hA:
undetectable
3aiaB-4h2hA:
undetectable		 3aiaA-4h2hA:
19.51
3aiaB-4h2hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 VAL A 139
GLN A 148
ARG A 167
ARG A 147
 None
 1.41A 3bjwE-4h2hA:
undetectable		 3bjwE-4h2hA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 8 GLY A 318
ALA A 319
ASP A 292
PRO A 346
ILE A 343
 None
None
0XW  A 403 ( 4.4A)
None
None
 1.28A 3el0A-4h2hA:
undetectable		 3el0A-4h2hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 ARG A 314
VAL A 131
THR A 128
 None
 0.70A 3k4vD-4h2hA:
undetectable		 3k4vD-4h2hA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		3 / 3 ASP A  41
ARG A 114
ALA A  39
 None
 0.79A 3mbgC-4h2hA:
undetectable		 3mbgC-4h2hA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 8 VAL A 326
VAL A  16
ASP A 298
ARG A 359
 None
 1.14A 3uy4A-4h2hA:
undetectable		 3uy4A-4h2hA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 HIS A 120
SER A 309
GLN A 347
VAL A 131
 None
 1.35A 4a99D-4h2hA:
undetectable		 4a99D-4h2hA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 11 ILE A  37
ALA A 106
GLY A  47
GLU A  48
GLY A 270
 None
 1.16A 4e47A-4h2hA:
undetectable		 4e47A-4h2hA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 11 ILE A  37
ALA A 106
GLY A  47
GLU A  48
GLY A 270
 None
 1.17A 4e47B-4h2hA:
undetectable		 4e47B-4h2hA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 TYR A 134
ALA A 322
ILE A  22
GLY A 263
ASP A 193
 None
None
None
None
MG  A 401 ( 2.7A)
 1.49A 4iilA-4h2hA:
4.1		 4iilA-4h2hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 TYR A 330
LEU A 351
ASP A 293
VAL A 131
 None
 1.25A 4nkvA-4h2hA:
undetectable		 4nkvA-4h2hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 10 PHE A 281
ASP A 293
ASP A 292
TYR A 239
GLY A 263
 None
None
0XW  A 403 ( 4.4A)
None
None
 1.38A 4qb9A-4h2hA:
undetectable		 4qb9A-4h2hA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 10 PHE A 281
ASP A 293
ASP A 292
TYR A 239
GLY A 263
 None
None
0XW  A 403 ( 4.4A)
None
None
 1.46A 4qb9C-4h2hA:
undetectable		 4qb9C-4h2hA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 PHE A 281
ASP A 293
ASP A 292
TYR A 239
GLY A 263
 None
None
0XW  A 403 ( 4.4A)
None
None
 1.48A 4qb9E-4h2hA:
undetectable		 4qb9E-4h2hA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 GLU A 218
TYR A 134
THR A 290
TYR A  56
 MG  A 401 ( 2.9A)
None
None
0XW  A 403 (-4.7A)
 1.33A 4qwpB-4h2hA:
undetectable		 4qwpB-4h2hA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 5 ARG A 184
PRO A 214
ILE A 213
ASP A 212
 None
 1.47A 4z4hA-4h2hA:
2.2		 4z4hA-4h2hA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 ALA A 303
LEU A 321
MET A 316
HIS A 289
LEU A 272
 None
 1.19A 4zn7A-4h2hA:
undetectable		 4zn7A-4h2hA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		6 / 12 PRO A 118
GLY A 112
GLY A 350
GLY A 352
LEU A 351
ALA A  80
 None
 1.41A 5c0oF-4h2hA:
undetectable		 5c0oF-4h2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 TYR A  98
THR A  33
THR A  32
GLY A  47
ALA A 102
 None
 1.12A 5lf7V-4h2hA:
undetectable
5lf7b-4h2hA:
undetectable		 5lf7V-4h2hA:
20.83
5lf7b-4h2hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 TYR A  98
THR A  33
THR A  32
GLY A  47
ALA A 102
 None
 1.11A 5lf7H-4h2hA:
undetectable
5lf7N-4h2hA:
undetectable		 5lf7H-4h2hA:
20.83
5lf7N-4h2hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 7 GLY A 270
HIS A 274
HIS A 108
ASP A 104
 None
 0.98A 5nnwD-4h2hA:
undetectable		 5nnwD-4h2hA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		4 / 7 GLY A 270
HIS A 274
HIS A 108
ASP A 104
 None
 0.91A 5no9D-4h2hA:
undetectable		 5no9D-4h2hA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 9 LEU A 122
HIS A 120
PRO A 118
GLY A 124
LEU A 115
 None
 1.36A 5o96E-4h2hA:
2.6
5o96F-4h2hA:
undetectable		 5o96E-4h2hA:
22.78
5o96F-4h2hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Salipiger
bermudensis) 		5 / 12 HIS A  11
THR A  32
ASP A 298
LEU A  13
GLY A 296
 None
 1.39A 6f3mD-4h2hA:
undetectable		 6f3mD-4h2hA:
22.72