SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		3 / 3 ASP A  22
LEU A  51
LEU A  49
 None
 0.78A 1ikeA-4h2kA:
undetectable		 1ikeA-4h2kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 11 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.22A 1jb0B-4h2kA:
undetectable		 1jb0B-4h2kA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 ALA A 112
LEU A 105
GLU A 113
LEU A  51
 None
 1.02A 1mt1D-4h2kA:
undetectable
1mt1E-4h2kA:
undetectable		 1mt1D-4h2kA:
20.45
1mt1E-4h2kA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		3 / 3 ASP A  22
LEU A  51
LEU A  49
 None
 0.76A 1np1B-4h2kA:
undetectable		 1np1B-4h2kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zA-4h2kA:
5.0		 1v7zA-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zB-4h2kA:
5.1		 1v7zB-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zD-4h2kA:
5.1		 1v7zD-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zE-4h2kA:
5.1		 1v7zE-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zF-4h2kA:
5.1		 1v7zF-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 THR A 131
GLU A 134
PHE A 219
ILE A 220
 None
ZN  A1001 (-3.9A)
None
None
 1.26A 2w98B-4h2kA:
undetectable		 2w98B-4h2kA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 ILE A  29
LEU A  12
ILE A 109
MET A 101
VAL A 145
 None
None
None
ZN  A1001 ( 4.4A)
None
 1.10A 2ygnA-4h2kA:
undetectable		 2ygnA-4h2kA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 11 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.21A 3pcqB-4h2kA:
undetectable		 3pcqB-4h2kA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 7 ALA A 127
ILE A 126
HIS A 122
GLY A  56
 None
 0.87A 3v4tH-4h2kA:
undetectable		 3v4tH-4h2kA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 PHE A  64
ILE A 255
ILE A 194
LEU A 190
ILE A  62
 None
 1.32A 3w67D-4h2kA:
undetectable		 3w67D-4h2kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 VAL A  70
VAL A   5
VAL A 244
LEU A  93
VAL A   6
 None
 1.26A 3w68C-4h2kA:
undetectable		 3w68C-4h2kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A  54
THR A 125
ALA A 127
LEU A 129
 None
 0.64A 4ik6B-4h2kA:
undetectable		 4ik6B-4h2kA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 ILE A 255
GLY A 162
GLY A 231
ALA A  65
MET A 108
 None
 1.11A 4kicB-4h2kA:
undetectable		 4kicB-4h2kA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		8 / 11 HIS A  67
ASP A 100
GLU A 134
GLU A 135
GLU A 163
ASN A 234
ILE A 237
HIS A 238
 ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1001 (-3.9A)
ZN  A1002 (-2.0A)
ZN  A1001 (-2.1A)
None
None
ZN  A1002 (-3.4A)
 0.26A 4pqaA-4h2kA:
42.3		 4pqaA-4h2kA:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		6 / 11 HIS A  67
ASP A 100
GLU A 134
GLU A 135
GLY A 213
ASN A 234
 ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1001 (-3.9A)
ZN  A1002 (-2.0A)
None
None
 1.04A 4pqaA-4h2kA:
42.3		 4pqaA-4h2kA:
38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 THR A 236
GLY A  97
GLY A  95
LEU A 105
ALA A 107
 None
 1.08A 4uckB-4h2kA:
undetectable		 4uckB-4h2kA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  93
GLY A 103
VAL A   6
SER A  17
GLY A  24
 None
 0.94A 5f9zA-4h2kA:
undetectable		 5f9zA-4h2kA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 HIS A 257
GLU A 254
ALA A 106
LEU A   8
 None
 1.01A 5igiA-4h2kA:
undetectable		 5igiA-4h2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 11 LEU A 105
GLY A 162
GLY A 231
LEU A  12
GLU A 135
 None
None
None
None
ZN  A1002 (-2.0A)
 1.00A 5o96G-4h2kA:
undetectable		 5o96G-4h2kA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.19A 5oy02-4h2kA:
undetectable		 5oy02-4h2kA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 10 PHE A  38
ILE A  62
ALA A  63
LEU A 128
ALA A  53
 None
 1.27A 5oy0b-4h2kA:
undetectable		 5oy0b-4h2kA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 GLU A 242
VAL A 244
PRO A 232
THR A 214
GLY A 213
 None
 1.33A 6mn8A-4h2kA:
undetectable		 6mn8A-4h2kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 LEU A 249
GLU A 242
VAL A 244
PRO A 232
THR A 214
 None
 1.15A 6mn8A-4h2kA:
undetectable		 6mn8A-4h2kA:
18.85