SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		4 / 6 ALA A  57
ASP A  64
ALA A  65
LEU A  83
 None
None
HEM  A 201 ( 3.8A)
HEM  A 201 (-4.5A)
 0.41A 1iwhA-4h2lA:
27.4		 1iwhA-4h2lA:
85.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.0A)
None
HEM  B 201 ( 4.0A)
HEM  B 201 (-3.4A)
 0.88A 1lh6A-4h2lB:
13.4		 1lh6A-4h2lB:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 10 ASP A  64
GLY A  60
ALA A  63
ILE A  17
GLY A  19
 None
 1.02A 1t7iA-4h2lA:
undetectable		 1t7iA-4h2lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 9 PHE A  46
LEU A  29
HIS A  58
LEU A 101
ALA A  63
 None
None
HEM  A 201 (-4.4A)
HEM  A 201 (-4.3A)
None
 1.38A 2bxdA-4h2lA:
3.6		 2bxdA-4h2lA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 11 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.12A 2bxeB-4h2lA:
undetectable		 2bxeB-4h2lA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 12 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
 None
None
HEM  A 201 (-3.4A)
None
HEM  A 201 ( 3.8A)
 0.97A 2bxpA-4h2lA:
2.5		 2bxpA-4h2lA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		4 / 4 ARG A  31
GLY A  25
GLU A  27
SER A 133
 None
 1.15A 2xctS-4h2lA:
undetectable
2xctU-4h2lA:
undetectable		 2xctS-4h2lA:
12.39
2xctU-4h2lA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 10 ASP A  64
GLY A  60
ALA A  63
ILE A  17
GLY A  19
 None
 1.02A 3oxwC-4h2lA:
undetectable		 3oxwC-4h2lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 None
 0.75A 3smtA-4h2lA:
undetectable		 3smtA-4h2lA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 12 LEU B  78
TYR B 130
LEU B  10
LEU B  14
GLY B  16
 None
 1.11A 4l9qB-4h2lB:
undetectable		 4l9qB-4h2lB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 12 GLU A  30
LEU A 105
GLY A  59
ALA A  63
ILE A  17
 None
 0.94A 4xe5A-4h2lA:
2.0		 4xe5A-4h2lA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		3 / 3 THR B   4
ASP B   5
ALA B   6
 None
 0.10A 5g5gB-4h2lB:
undetectable		 5g5gB-4h2lB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.21A 5qggA-4h2lB:
undetectable		 5qggA-4h2lB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.19A 5qgoA-4h2lB:
undetectable		 5qgoA-4h2lB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.20A 5qgpA-4h2lB:
undetectable		 5qgpA-4h2lB:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4h2l ALPHA-GLOBIN
BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 8 PRO A  95
THR A 134
THR A 137
TYR A 140
TRP B  37
 None
 0.48A 5x2sI-4h2lA:
26.1
5x2sJ-4h2lA:
21.9
5x2sK-4h2lA:
26.3		 5x2sI-4h2lA:
85.11
5x2sJ-4h2lA:
40.54
5x2sK-4h2lA:
85.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4h2l ALPHA-GLOBIN
BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 8 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  37
 None
 0.60A 5x2tI-4h2lA:
26.3
5x2tJ-4h2lA:
22.1
5x2tK-4h2lA:
26.3
5x2tL-4h2lA:
20.5		 5x2tI-4h2lA:
85.11
5x2tJ-4h2lA:
40.54
5x2tK-4h2lA:
85.11
5x2tL-4h2lA:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4h2l ALPHA-GLOBIN
(Peromyscus
maniculatus) 		5 / 12 ASP A  64
GLY A  60
ALA A  63
ILE A  17
GLY A  19
 None
 0.95A 6dj1B-4h2lA:
undetectable		 6dj1B-4h2lA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.2A)
HEM  B 201 (-3.1A)
None
 1.13A 6ew0B-4h2lB:
undetectable		 6ew0B-4h2lB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.2A)
HEM  B 201 (-3.1A)
None
 1.13A 6ew0D-4h2lB:
undetectable		 6ew0D-4h2lB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.2A)
HEM  B 201 (-3.1A)
None
 1.13A 6ew0H-4h2lB:
undetectable		 6ew0H-4h2lB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4h2l BETA GLOBIN
(Peromyscus
maniculatus) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.2A)
HEM  B 201 (-3.1A)
None
 1.13A 6ew0I-4h2lB:
undetectable		 6ew0I-4h2lB:
18.98