SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.13A 1bsxA-4h2xB:
undetectable		 1bsxA-4h2xB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.13A 1bsxB-4h2xB:
undetectable		 1bsxB-4h2xB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.02A 1v8bA-4h2xB:
undetectable		 1v8bA-4h2xB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.03A 1v8bB-4h2xB:
undetectable		 1v8bB-4h2xB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.00A 1v8bD-4h2xB:
undetectable		 1v8bD-4h2xB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.07A 2h79A-4h2xB:
undetectable		 2h79A-4h2xB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		4 / 7 GLN B 229
TYR B 256
TYR B 135
ILE B 180
 None
 1.19A 2ph9A-4h2xB:
undetectable
2ph9B-4h2xB:
undetectable		 2ph9A-4h2xB:
20.74
2ph9B-4h2xB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.00A 3g1uB-4h2xB:
undetectable		 3g1uB-4h2xB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.07A 3gwsX-4h2xB:
undetectable		 3gwsX-4h2xB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		4 / 7 HIS B 257
GLU B 237
PHE B  85
PRO B 216
 None
 1.34A 3ql6A-4h2xB:
0.3		 3ql6A-4h2xB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.10A 4lnwA-4h2xB:
undetectable		 4lnwA-4h2xB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 200
ALA B 290
LEU B 287
LEU B 238
ILE B 240
 None
 1.09A 4lnxA-4h2xB:
undetectable		 4lnxA-4h2xB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.85A 4q15B-4h2xB:
21.1		 4q15B-4h2xB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.76A 4ydqA-4h2xB:
19.9		 4ydqA-4h2xB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.18A 5m5kB-4h2xB:
undetectable		 5m5kB-4h2xB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.05A 5m66A-4h2xB:
undetectable		 5m66A-4h2xB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 267
GLY B 262
HIS B 276
ILE B 137
ALA B 138
 None
 1.10A 5n0wB-4h2xB:
undetectable		 5n0wB-4h2xB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 ILE B 267
GLY B 262
HIS B 276
ILE B 137
ALA B 138
 None
 1.14A 5n0xA-4h2xB:
undetectable		 5n0xA-4h2xB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		4 / 7 LEU B 287
ALA B 201
ILE B 309
LEU B  53
 None
 1.00A 5te8A-4h2xB:
undetectable		 5te8A-4h2xB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B 242
HIS B 293
THR B 207
GLY B 296
HIS B 295
 None
 1.04A 5utuF-4h2xB:
undetectable		 5utuF-4h2xB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		3 / 3 TYR B 135
ALA B 129
TYR B 132
 None
G5A  B 402 (-3.6A)
None
 0.82A 5uunB-4h2xB:
undetectable		 5uunB-4h2xB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLY B 283
 None
None
None
G5A  B 402 (-2.8A)
CL  B 403 ( 3.2A)
 1.07A 5xipA-4h2xB:
18.5		 5xipA-4h2xB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.87A 5xiqB-4h2xB:
10.1		 5xiqB-4h2xB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 12 LEU B  76
PHE B  85
PRO B 128
ARG B 159
GLU B 176
 None
None
None
G5A  B 402 (-2.8A)
ZN  B 401 ( 2.3A)
 0.86A 5xiqD-4h2xB:
19.6		 5xiqD-4h2xB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 10 ARG B 159
GLU B 161
PHE B 172
GLY B 283
ARG B 286
 G5A  B 402 (-2.8A)
G5A  B 402 (-3.8A)
G5A  B 402 (-3.7A)
CL  B 403 ( 3.2A)
G5A  B 402 ( 3.8A)
 0.46A 6bniA-4h2xB:
11.1		 6bniA-4h2xB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4h2x AMINO
ACID--[ACYL-CARRIER-
PROTEIN] LIGASE 1
(Agrobacterium
fabrum;
Bradyrhizobium
diazoefficiens) 		5 / 10 ARG B 159
GLU B 161
PHE B 172
GLY B 283
ARG B 286
 G5A  B 402 (-2.8A)
G5A  B 402 (-3.8A)
G5A  B 402 (-3.7A)
CL  B 403 ( 3.2A)
G5A  B 402 ( 3.8A)
 0.51A 6bniB-4h2xB:
12.0		 6bniB-4h2xB:
12.90