SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 198
HIS A  59
PHE A  51
PHE A 114
TYR A 211
 FE2  A 301 (-3.3A)
FE2  A 301 (-3.4A)
None
None
None
 1.41A 1c3sA-4h3eA:
undetectable		 1c3sA-4h3eA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 196
GLY A 180
ASN A 102
PRO A 182
 None
 1.21A 1dedA-4h3eA:
undetectable		 1dedA-4h3eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 11 LEU A 212
VAL A 193
ILE A 117
ILE A 219
VAL A  50
 None
 1.41A 1gx9A-4h3eA:
undetectable		 1gx9A-4h3eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 ILE A 219
TRP A 221
PHE A 128
GLU A 222
 None
 1.40A 1nsiA-4h3eA:
undetectable
1nsiB-4h3eA:
undetectable		 1nsiA-4h3eA:
19.46
1nsiB-4h3eA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 221
PHE A 128
GLU A 222
ILE A 219
 None
 1.39A 1nsiA-4h3eA:
undetectable
1nsiB-4h3eA:
undetectable		 1nsiA-4h3eA:
19.46
1nsiB-4h3eA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 221
PHE A 128
GLU A 222
ILE A 219
 None
 1.41A 1nsiC-4h3eA:
undetectable
1nsiD-4h3eA:
undetectable		 1nsiC-4h3eA:
19.46
1nsiD-4h3eA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 PHE A 101
SER A 177
ALA A 179
ASN A 109
 None
 0.99A 1pnlA-4h3eA:
undetectable
1pnlB-4h3eA:
undetectable		 1pnlA-4h3eA:
20.24
1pnlB-4h3eA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 100
THR A 184
ILE A  87
TYR A  79
 None
 1.15A 1qvtA-4h3eA:
undetectable		 1qvtA-4h3eA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 198
HIS A  59
PHE A  51
PHE A 114
TYR A 211
 FE2  A 301 (-3.3A)
FE2  A 301 (-3.4A)
None
None
None
 1.37A 1t69A-4h3eA:
undetectable		 1t69A-4h3eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 221
PHE A 128
GLU A 222
ILE A 219
 None
 1.37A 4cx7A-4h3eA:
undetectable
4cx7B-4h3eA:
undetectable		 4cx7A-4h3eA:
19.46
4cx7B-4h3eA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 211
HIS A  59
HIS A 110
TYR A 113
 None
FE2  A 301 (-3.4A)
FE2  A 301 (-3.3A)
None
 1.47A 4df2A-4h3eA:
undetectable		 4df2A-4h3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 5 VAL A 132
LEU A 161
VAL A 190
PHE A 128
 None
 0.99A 4lb0B-4h3eA:
undetectable		 4lb0B-4h3eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 198
HIS A  59
PHE A  51
PHE A 114
TYR A 211
 FE2  A 301 (-3.3A)
FE2  A 301 (-3.4A)
None
None
None
 1.49A 5eenB-4h3eA:
undetectable		 5eenB-4h3eA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 158
ALA A 192
HIS A  59
HIS A 110
 None
None
FE2  A 301 (-3.4A)
FE2  A 301 (-3.3A)
 1.12A 5km8A-4h3eA:
undetectable
5km8B-4h3eA:
undetectable		 5km8A-4h3eA:
21.15
5km8B-4h3eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4h3e SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 128
VAL A 224
PHE A 112
THR A  22
 None
 1.16A 5t7bA-4h3eA:
undetectable		 5t7bA-4h3eA:
13.10