SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 348
ARG A 402
CYH A 372
 ZN  A 901 (-2.3A)
None
ZN  A 901 (-2.3A)
 1.36A 1p9gA-4h3sA:
undetectable		 1p9gA-4h3sA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 253
TYR A 287
LYS A 319
 None
 1.03A 1uujB-4h3sA:
undetectable		 1uujB-4h3sA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 489
GLY A 267
HIS A 265
ILE A 491
 GOL  A 903 (-4.9A)
GOL  A 903 (-3.0A)
GOL  A 903 (-4.0A)
None
 0.95A 1xf1A-4h3sA:
undetectable		 1xf1A-4h3sA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 504
ILE A 501
LEU A 496
SER A 497
 None
ACT  A 914 ( 4.1A)
None
None
 0.99A 2byoA-4h3sA:
undetectable		 2byoA-4h3sA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.20A 3fhjA-4h3sA:
6.2		 3fhjA-4h3sA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 10 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.22A 3fhjE-4h3sA:
6.3		 3fhjE-4h3sA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.22A 3fi0A-4h3sA:
6.2		 3fi0A-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.23A 3fi0C-4h3sA:
4.4		 3fi0C-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.20A 3fi0H-4h3sA:
6.3		 3fi0H-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.32A 3fi0J-4h3sA:
4.9		 3fi0J-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.20A 3fi0K-4h3sA:
6.3		 3fi0K-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.17A 3fi0M-4h3sA:
6.1		 3fi0M-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.20A 3fi0N-4h3sA:
6.2		 3fi0N-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 637
ASP A 620
ILE A 616
VAL A 579
VAL A 666
 None
 1.16A 3fi0O-4h3sA:
6.1		 3fi0O-4h3sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 419
ASN A 340
LEU A 337
LEU A 446
THR A 439
 None
 1.31A 3jw5A-4h3sA:
undetectable		 3jw5A-4h3sA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 306
PHE A 290
ASP A 291
GLU A 259
 None
 0.94A 3kp6A-4h3sA:
undetectable
3kp6B-4h3sA:
undetectable		 3kp6A-4h3sA:
10.66
3kp6B-4h3sA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 730
PHE A 710
LYS A 711
 CL  A 911 (-3.5A)
None
None
 0.66A 3u88A-4h3sA:
undetectable		 3u88A-4h3sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 315
ILE A 534
ILE A 538
VAL A 543
PHE A 223
 None
 1.13A 3w67A-4h3sA:
undetectable		 3w67A-4h3sA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 469
ASP A 474
GLU A 239
LEU A 446
 GOL  A 906 ( 4.9A)
None
None
None
 1.11A 4ax8A-4h3sA:
undetectable		 4ax8A-4h3sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 326
ARG A 289
SER A 323
 None
 0.94A 4dr2I-4h3sA:
undetectable
4dr2J-4h3sA:
undetectable		 4dr2I-4h3sA:
10.26
4dr2J-4h3sA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		5 / 6 ALA A 425
ASN A 424
LEU A 423
VAL A 422
GLU A 398
 None
 1.25A 4g24A-4h3sA:
undetectable		 4g24A-4h3sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 4 SER A 619
GLY A 782
GLU A 556
 None
GOL  A 904 ( 4.1A)
None
 0.33A 4juoA-4h3sA:
undetectable
4juoC-4h3sA:
undetectable		 4juoA-4h3sA:
21.40
4juoC-4h3sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 326
ARG A 289
SER A 323
 None
 0.97A 4lf7I-4h3sA:
undetectable
4lf7J-4h3sA:
undetectable		 4lf7I-4h3sA:
10.26
4lf7J-4h3sA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 326
ARG A 289
SER A 323
 None
 0.97A 4lf8I-4h3sA:
undetectable
4lf8J-4h3sA:
undetectable		 4lf8I-4h3sA:
10.26
4lf8J-4h3sA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 707
VAL A 801
GLU A 556
ARG A 560
 None
 1.32A 4mv7A-4h3sA:
3.7		 4mv7A-4h3sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 340
LYS A 342
LEU A 330
PHE A 327
 None
None
None
GOL  A 905 (-4.8A)
 1.11A 4yv5A-4h3sA:
undetectable		 4yv5A-4h3sA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 263
ALA A 299
TYR A 302
 None
 0.80A 5uunB-4h3sA:
undetectable		 5uunB-4h3sA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 235
GLU A 232
HIS A 455
ALA A 482
 None
None
ACT  A 913 (-4.3A)
None
 1.10A 6f6jC-4h3sA:
undetectable
6f6jD-4h3sA:
undetectable		 6f6jC-4h3sA:
17.39
6f6jD-4h3sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4h3s GLUTAMINE-TRNA
LIGASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 706
VAL A 733
ILE A 796
GLU A 789
 None
 1.06A 6hzpA-4h3sA:
undetectable		 6hzpA-4h3sA:
20.26