SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 4 HIS A 165
LEU A 101
LEU A   9
LEU A  60
 None
 1.04A 1a4lD-4h3tA:
undetectable		 1a4lD-4h3tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 LEU A  29
PHE A  33
LEU A  15
LEU A  49
VAL A  44
 None
 1.01A 1hrkA-4h3tA:
undetectable		 1hrkA-4h3tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		3 / 3 GLN A 411
HIS A 408
ARG A 524
 None
 1.00A 1zlqA-4h3tA:
undetectable		 1zlqA-4h3tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 9 LEU A 101
PHE A 102
LEU A 161
HIS A 165
LEU A 128
 None
 1.26A 2bxeA-4h3tA:
3.4		 2bxeA-4h3tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 LEU A  15
PHE A  42
LEU A  29
LEU A  60
ALA A  59
 None
 1.10A 2bxpA-4h3tA:
2.4		 2bxpA-4h3tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 7 SER A 169
ALA A 170
SER A 171
SER A 370
 None
 0.96A 2i91A-4h3tA:
undetectable		 2i91A-4h3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 7 SER A 169
ALA A 170
SER A 171
SER A 370
 None
 0.96A 2i91B-4h3tA:
undetectable		 2i91B-4h3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 4 LEU A 495
ARG A 325
LEU A 460
ALA A 453
 None
 1.20A 3b9mA-4h3tA:
2.7		 3b9mA-4h3tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 7 VAL A 286
ARG A  55
VAL A 294
PHE A 255
 GOL  A 602 (-3.6A)
None
None
None
 1.26A 3dqrA-4h3tA:
undetectable
3dqrB-4h3tA:
undetectable		 3dqrA-4h3tA:
21.39
3dqrB-4h3tA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 VAL A  57
LEU A  60
LEU A 211
PHE A  92
ILE A  88
 None
 1.13A 3kk6B-4h3tA:
undetectable		 3kk6B-4h3tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 VAL A 200
VAL A 346
LEU A 385
LEU A 343
GLY A 204
 None
 1.07A 3rr3C-4h3tA:
undetectable		 3rr3C-4h3tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 VAL A 200
VAL A 346
LEU A 385
LEU A 343
GLY A 204
 None
 1.06A 3rr3D-4h3tA:
1.4		 3rr3D-4h3tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		6 / 12 VAL A  57
LEU A  60
ILE A  88
PHE A  19
SER A  28
LEU A  29
 None
 1.31A 4o1zB-4h3tA:
undetectable		 4o1zB-4h3tA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 10 GLY A 192
GLY A 168
GLY A 259
ARG A 261
ILE A 262
 GOL  A 602 ( 4.8A)
None
None
None
None
 0.99A 5aqyA-4h3tA:
undetectable		 5aqyA-4h3tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 11 PRO A 384
LEU A 468
VAL A 323
LEU A 327
TYR A 464
 None
 1.36A 5hbmA-4h3tA:
undetectable		 5hbmA-4h3tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 6 ALA A 395
PRO A 480
VAL A 398
ASP A 392
 None
 1.22A 5umd2-4h3tA:
undetectable
5umdF-4h3tA:
undetectable		 5umd2-4h3tA:
8.30
5umdF-4h3tA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 4 SER A  25
THR A  38
ASP A  81
ASP A  31
 None
 1.45A 5vimA-4h3tA:
undetectable		 5vimA-4h3tA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 5 TYR A 464
ARG A 465
THR A 469
LEU A 471
 None
 1.42A 5wauJ-4h3tA:
undetectable		 5wauJ-4h3tA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		5 / 12 GLY A 192
GLY A 283
GLY A 259
VAL A 286
ALA A 282
 GOL  A 602 ( 4.8A)
None
None
GOL  A 602 (-3.6A)
None
 1.23A 5x7fA-4h3tA:
undetectable		 5x7fA-4h3tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Acidimicrobium
ferrooxidans) 		4 / 5 TYR A 464
ARG A 465
THR A 469
LEU A 471
 None
 1.43A 5z86J-4h3tA:
undetectable		 5z86J-4h3tA:
7.52