SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 12 LEU A 370
LEU A 199
TYR A 163
ILE A 196
PHE A 290
 None
 1.24A 1fmlA-4h3vA:
undetectable		 1fmlA-4h3vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 12 LEU A 370
LEU A 199
TYR A 163
ILE A 196
PHE A 290
 None
 1.25A 1fmlB-4h3vA:
undetectable		 1fmlB-4h3vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 11 ALA A 194
LEU A 189
LEU A 215
SER A 376
ALA A 372
 None
 1.16A 1h9zA-4h3vA:
undetectable		 1h9zA-4h3vA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		3 / 3 ASP A 182
GLU A 374
ARG A 266
 None
 0.65A 1wopA-4h3vA:
undetectable		 1wopA-4h3vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 190
ASN A 107
ASP A 191
ALA A 188
ALA A 247
 None
 1.12A 2br4B-4h3vA:
2.5		 2br4B-4h3vA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 8 ILE A   6
GLY A   7
LEU A  67
LEU A  68
 None
 0.87A 2vctB-4h3vA:
undetectable		 2vctB-4h3vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 8 ILE A   6
GLY A   7
LEU A  67
LEU A  68
 None
 0.84A 2vctC-4h3vA:
undetectable		 2vctC-4h3vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 9 ASP A 355
PRO A 356
ALA A 349
ILE A 350
HIS A  98
 None
 1.03A 3aptB-4h3vA:
undetectable		 3aptB-4h3vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 213
ASP A 245
ALA A 248
VAL A 373
GLU A 384
 None
 0.93A 3nvkI-4h3vA:
3.5		 3nvkI-4h3vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 8 PHE A 250
VAL A 197
ILE A 279
PHE A 254
 None
 0.84A 3uqbA-4h3vA:
undetectable		 3uqbA-4h3vA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 8 LEU A 346
ILE A 350
GLY A 126
ILE A 127
 None
 0.86A 3wxoA-4h3vA:
undetectable		 3wxoA-4h3vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 6 THR A 155
GLY A 281
ARG A 145
ILE A 279
 None
 0.89A 4acbC-4h3vA:
undetectable		 4acbC-4h3vA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 10 LEU A 147
ILE A 279
GLY A 151
GLY A 154
THR A 204
 None
 1.05A 4fakA-4h3vA:
undetectable		 4fakA-4h3vA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		3 / 3 ASP A 198
LEU A 199
PHE A 202
 None
 0.59A 4pthA-4h3vA:
undetectable		 4pthA-4h3vA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.15A 5a06A-4h3vA:
16.8		 5a06A-4h3vA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
ILE A 192
 None
 1.04A 5a06B-4h3vA:
36.8		 5a06B-4h3vA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.13A 5a06C-4h3vA:
36.8		 5a06C-4h3vA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.15A 5a06D-4h3vA:
36.7		 5a06D-4h3vA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.13A 5a06E-4h3vA:
36.6		 5a06E-4h3vA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 7 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.11A 5a06F-4h3vA:
36.6		 5a06F-4h3vA:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		4 / 4 ALA A 124
PRO A 356
LEU A  75
HIS A  98
 None
 1.28A 5eskA-4h3vA:
undetectable		 5eskA-4h3vA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		5 / 12 GLY A 284
GLY A 154
ILE A 313
ASN A 280
VAL A 156
 None
 0.96A 6mhtA-4h3vA:
3.5		 6mhtA-4h3vA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4h3v OXIDOREDUCTASE
DOMAIN PROTEIN
(Kribbella
flavida) 		3 / 3 ARG A 368
LEU A 364
PHE A 360
 None
 0.67A 6nknP-4h3vA:
undetectable		 6nknP-4h3vA:
21.01