SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 12 LEU A 116
LEU A 223
SER A  62
VAL A 186
HIS A 120
 None
 1.22A 1db1A-4h3wA:
undetectable		 1db1A-4h3wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 12 LEU A 221
VAL A 219
ILE A 185
LEU A 182
PRO A 166
 None
None
MLY  A 181 ( 4.4A)
MLY  A 181 ( 4.7A)
None
 1.12A 2qk8A-4h3wA:
undetectable		 2qk8A-4h3wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 11 LEU A 215
LEU A 123
SER A 137
LEU A 136
LEU A 155
 MLY  A 124 ( 4.7A)
MLY  A 124 ( 4.0A)
None
None
None
 1.03A 2xn5A-4h3wA:
undetectable		 2xn5A-4h3wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 11 ILE A 121
LEU A 195
ILE A  99
VAL A 186
LEU A 221
 None
 1.21A 3a51A-4h3wA:
undetectable		 3a51A-4h3wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 12 ILE A 121
LEU A 195
ILE A  99
VAL A 186
LEU A 221
 None
 1.20A 3a51D-4h3wA:
undetectable		 3a51D-4h3wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		3 / 3 ASN A 263
MET A 273
PHE A 340
 None
 1.14A 3g4lD-4h3wA:
undetectable		 3g4lD-4h3wA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 12 VAL A 274
ILE A 275
ILE A 285
VAL A 283
PRO A 282
 None
None
None
MLY  A 310 ( 4.7A)
None
 0.75A 3kpdC-4h3wA:
undetectable		 3kpdC-4h3wA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 8 ILE A  80
ALA A 211
LEU A 212
LEU A 197
 MLY  A  81 ( 3.8A)
MLY  A 128 ( 3.9A)
None
None
 0.77A 3ozwA-4h3wA:
undetectable		 3ozwA-4h3wA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 7 VAL A 283
VAL A 246
PHE A 241
ILE A 317
 MLY  A 310 ( 4.7A)
MLY  A 312 ( 4.2A)
None
None
 0.92A 3zjqA-4h3wA:
undetectable		 3zjqA-4h3wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 7 VAL A 283
VAL A 246
PHE A 241
ILE A 317
 MLY  A 310 ( 4.7A)
MLY  A 312 ( 4.2A)
None
None
 0.92A 3zjqB-4h3wA:
undetectable		 3zjqB-4h3wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 11 GLY A  76
ILE A  99
ILE A 138
LEU A 136
ILE A 121
 None
 0.95A 4dt8A-4h3wA:
undetectable		 4dt8A-4h3wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		5 / 10 GLY A  76
ILE A  99
ILE A 138
LEU A 136
ILE A 121
 None
 0.98A 4dt8B-4h3wA:
undetectable		 4dt8B-4h3wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		3 / 3 ASP A  90
ASP A 200
ASN A 206
 MLY  A  91 ( 4.2A)
MLY  A 202 ( 4.0A)
MLY  A 202 ( 3.4A)
 0.77A 4q5mA-4h3wA:
undetectable		 4q5mA-4h3wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ASP A 133
ALA A 199
LYS A 203
THR A 154
 None
None
MLY  A 202 ( 2.9A)
None
 1.46A 4w5rA-4h3wA:
undetectable		 4w5rA-4h3wA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ASP A 133
ALA A 199
LYS A 203
THR A 154
 None
None
MLY  A 202 ( 2.9A)
None
 1.49A 4w5tA-4h3wA:
undetectable		 4w5tA-4h3wA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 6 ASP A 133
ALA A 199
LYS A 203
THR A 154
 None
None
MLY  A 202 ( 2.9A)
None
 1.48A 4z4cA-4h3wA:
undetectable		 4z4cA-4h3wA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LEU A 332
VAL A  54
ASP A  53
 MLY  A 333 ( 3.7A)
None
None
 0.66A 5x23A-4h3wA:
undetectable		 5x23A-4h3wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 6 GLY A  47
TYR A  48
LEU A 321
VAL A 261
 None
MLY  A 337 ( 4.5A)
None
None
 0.92A 5x80A-4h3wA:
undetectable
5x80B-4h3wA:
undetectable		 5x80A-4h3wA:
21.07
5x80B-4h3wA:
21.07