SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		6 / 12 PRO A  93
GLY A 117
VAL A 141
LEU A 142
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 1.25A 1uakA-4h3zA:
27.4		 1uakA-4h3zA:
52.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		9 / 12 SER A  92
PRO A  93
GLY A 117
SER A 136
VAL A 141
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.24A 1uakA-4h3zA:
27.4		 1uakA-4h3zA:
52.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		8 / 12 SER A  92
PRO A  93
GLY A 117
SER A 136
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.36A 3axzA-4h3zA:
24.1		 3axzA-4h3zA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 12 GLY A 178
ILE A 228
ALA A 216
LEU A 245
ASP A 241
 None
 1.00A 3gwvA-4h3zA:
undetectable		 3gwvA-4h3zA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		4 / 5 SER A 136
THR A  97
GLU A 134
ASP A 128
 SAH  A 301 (-3.4A)
None
None
None
 1.22A 3tm4A-4h3zA:
undetectable		 3tm4A-4h3zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		4 / 5 SER A 136
THR A  97
GLU A 134
ASP A 128
 SAH  A 301 (-3.4A)
None
None
None
 1.22A 3tm4B-4h3zA:
undetectable		 3tm4B-4h3zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 12 GLY A  32
VAL A 157
LEU A  16
PHE A   3
ILE A   5
 None
 1.26A 4pd9A-4h3zA:
undetectable		 4pd9A-4h3zA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		8 / 12 SER A  92
PRO A  93
GLY A 117
GLU A 120
SER A 136
LEU A 142
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.61A 4yvgA-4h3zA:
28.3		 4yvgA-4h3zA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		8 / 12 SER A  92
PRO A  93
GLY A 117
SER A 136
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.21A 4yvgA-4h3zA:
28.3		 4yvgA-4h3zA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 12 ILE A  83
PHE A   3
GLY A  32
LEU A 160
HIS A 159
 None
None
None
None
CL  A 302 (-4.7A)
 1.23A 4zdyA-4h3zA:
undetectable		 4zdyA-4h3zA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 12 ILE A  83
PHE A   3
GLY A  32
LEU A 160
HIS A 159
 None
None
None
None
CL  A 302 (-4.7A)
 1.26A 5esgA-4h3zA:
undetectable		 5esgA-4h3zA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 10 PRO A  93
GLY A 117
LEU A 137
VAL A 141
LEU A 142
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
 0.67A 5o96G-4h3zA:
6.7
5o96H-4h3zA:
6.7		 5o96G-4h3zA:
21.43
5o96H-4h3zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		5 / 9 PRO A  38
LEU A   8
VAL A   6
LEU A 115
PHE A  13
 None
 1.47A 5tixA-4h3zA:
undetectable		 5tixA-4h3zA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		8 / 12 PRO A  93
GLY A 117
SER A 136
VAL A 141
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.22A 5wyqA-4h3zA:
27.8		 5wyqA-4h3zA:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		7 / 12 PRO A  93
GLY A 117
SER A 136
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.23A 5wyqB-4h3zA:
27.8		 5wyqB-4h3zA:
53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		4 / 4 PHE A 106
LEU A  16
LEU A 114
VAL A 157
 None
 1.04A 5xxiA-4h3zA:
undetectable		 5xxiA-4h3zA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		4 / 4 ARG A 158
SER A 174
ASP A 181
HIS A 184
 None
 0.67A 5zhmA-4h3zA:
27.1		 5zhmA-4h3zA:
52.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Paraburkholderia
phymatum) 		9 / 12 PRO A  93
GLY A 117
GLU A 120
SER A 136
VAL A 141
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.42A 5zhmB-4h3zA:
26.5		 5zhmB-4h3zA:
52.31