SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		5 / 11 LEU A 333
ILE A 288
LEU A 307
VAL A 278
PHE A 207
 None
 1.42A 1tw4A-4h40A:
undetectable		 1tw4A-4h40A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A  37
VAL A  82
LEU A 147
VAL A 115
ILE A 140
 None
 1.02A 3w68B-4h40A:
undetectable		 3w68B-4h40A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		4 / 7 LEU A 294
LEU A 218
THR A 331
THR A 301
 None
 0.93A 4z90A-4h40A:
undetectable
4z90B-4h40A:
undetectable
4z90C-4h40A:
undetectable
4z90D-4h40A:
undetectable
4z90E-4h40A:
undetectable		 4z90A-4h40A:
22.55
4z90B-4h40A:
22.55
4z90C-4h40A:
22.55
4z90D-4h40A:
22.55
4z90E-4h40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		5 / 12 ARG A  79
LEU A  98
VAL A 115
ALA A 144
SER A 142
 None
 1.07A 5ikqA-4h40A:
undetectable		 5ikqA-4h40A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		5 / 12 ARG A  79
LEU A  98
GLY A 119
ALA A 144
SER A 142
 None
 1.06A 5ikqB-4h40A:
undetectable		 5ikqB-4h40A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		5 / 12 ARG A  79
LEU A  98
VAL A 115
ALA A 144
SER A 142
 None
 1.09A 5ikqB-4h40A:
undetectable		 5ikqB-4h40A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		4 / 8 ILE A  37
LEU A 193
LEU A 195
MET A 131
 None
 0.75A 5u4sB-4h40A:
undetectable		 5u4sB-4h40A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4h40 PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
fragilis) 		3 / 3 GLY A 298
THR A 217
GLU A 219
 None
 0.64A 6b58A-4h40A:
undetectable		 6b58A-4h40A:
19.83