SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  75
HIS A 341
PRO A  73
 None
 0.60A 1d8cA-4h41A:
3.6		 1d8cA-4h41A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 349
GLU A 338
PRO A  73
ASP A  66
 None
 1.49A 1i7zB-4h41A:
undetectable		 1i7zB-4h41A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.22A 2aowA-4h41A:
2.1		 2aowA-4h41A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.16A 2aoxA-4h41A:
undetectable		 2aoxA-4h41A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.15A 2aoxB-4h41A:
0.0		 2aoxB-4h41A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 157
THR A 196
ILE A 200
PHE A 203
 PE4  A 405 (-2.4A)
None
None
None
 1.16A 2jc9A-4h41A:
undetectable		 2jc9A-4h41A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		6 / 9 LEU A  58
ILE A  60
ILE A 335
THR A 298
ALA A 326
LEU A 323
 None
 1.20A 2m9qA-4h41A:
undetectable		 2m9qA-4h41A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 131
SER A 340
TYR A 176
VAL A 125
 None
 1.26A 2y05A-4h41A:
undetectable
2y05B-4h41A:
undetectable		 2y05A-4h41A:
21.86
2y05B-4h41A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 184
LEU A 132
ILE A  94
ASP A  95
LEU A  65
 None
 0.96A 2zbpA-4h41A:
undetectable		 2zbpA-4h41A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 168
SER A 214
PHE A 183
GLY A 145
SER A 102
 None
 1.24A 3kk6B-4h41A:
undetectable		 3kk6B-4h41A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 198
CYH A 266
PHE A 220
PHE A 203
 PE4  A 405 ( 3.1A)
None
None
None
 1.04A 3ko0L-4h41A:
undetectable
3ko0N-4h41A:
undetectable		 3ko0L-4h41A:
16.76
3ko0N-4h41A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 203
GLY A 198
CYH A 266
PHE A 220
 None
PE4  A 405 ( 3.1A)
None
None
 1.12A 3ko0K-4h41A:
undetectable
3ko0S-4h41A:
undetectable		 3ko0K-4h41A:
16.76
3ko0S-4h41A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  66
GLU A 191
SER A 347
 None
UNL  A 401 ( 3.2A)
None
 0.72A 3p2kA-4h41A:
undetectable		 3p2kA-4h41A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 LYS A 229
GLN A 269
ILE A  72
LEU A 312
 None
UNL  A 401 ( 3.7A)
None
None
 1.31A 3qt0A-4h41A:
undetectable		 3qt0A-4h41A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
 None
 1.15A 3ut5B-4h41A:
3.6		 3ut5B-4h41A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 353
ARG A  91
GLU A 361
ARG A 358
 None
 1.36A 4bqfA-4h41A:
undetectable		 4bqfA-4h41A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A 355
ILE A  92
GLY A 353
PHE A 339
 None
 1.03A 4dc3A-4h41A:
undetectable		 4dc3A-4h41A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 271
ILE A 225
ASN A 285
MET A 343
 None
 1.00A 4g0vA-4h41A:
1.5		 4g0vA-4h41A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 202
MET A 206
ASN A 165
GLY A 150
ASP A 148
 None
 1.24A 4qckA-4h41A:
undetectable		 4qckA-4h41A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
 None
 1.10A 4x1iD-4h41A:
3.5		 4x1iD-4h41A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
 None
 1.15A 4x20D-4h41A:
3.3		 4x20D-4h41A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 169
LEU A 146
GLY A 207
LYS A 208
 None
None
None
PG4  A 409 (-2.9A)
 1.02A 4z69A-4h41A:
undetectable		 4z69A-4h41A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ASP A  66
HIS A  70
ASN A 299
GLN A 269
 None
1PE  A 406 ( 2.7A)
UNL  A 401 ( 3.6A)
UNL  A 401 ( 3.7A)
 1.48A 5il1A-4h41A:
0.0		 5il1A-4h41A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 273
ILE A 225
PHE A 268
GLU A 249
TRP A 252
 None
 1.21A 5lg3G-4h41A:
undetectable		 5lg3G-4h41A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 273
ILE A 225
PHE A 268
GLU A 249
TRP A 252
 None
 1.19A 5lg3H-4h41A:
undetectable		 5lg3H-4h41A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 273
ILE A 225
PHE A 268
GLU A 249
TRP A 252
 None
 1.20A 5lg3J-4h41A:
undetectable		 5lg3J-4h41A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 264
GLY A 216
PRO A 218
TRP A 186
 None
 0.97A 5nn8A-4h41A:
1.9		 5nn8A-4h41A:
15.46