SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		4 / 8 MET A  64
LEU A  78
ARG A  91
GLY A 123
 None
 1.03A 2qd5B-4h43A:
undetectable		 2qd5B-4h43A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		6 / 10 LEU A 187
VAL A 192
GLY A 191
LEU A 121
SER A 122
ALA A 117
 None
 1.09A 2v3kA-4h43A:
undetectable		 2v3kA-4h43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A 187
GLY A 191
LEU A 121
SER A 122
 None
 0.86A 3aiaA-4h43A:
undetectable		 3aiaA-4h43A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 12 PHE A 172
LEU A 173
GLY A 102
ASP A 162
PHE A 105
 None
 1.34A 3tbgC-4h43A:
undetectable		 3tbgC-4h43A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 12 PHE A 179
ARG A 186
VAL A 109
LEU A 121
LEU A 157
 None
 1.36A 4qzuA-4h43A:
undetectable		 4qzuA-4h43A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		4 / 7 LEU A  33
LEU A 238
ARG A 177
LEU A 173
 None
 0.72A 4wg0B-4h43A:
undetectable
4wg0C-4h43A:
undetectable		 4wg0B-4h43A:
8.57
4wg0C-4h43A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4h43 27.5 KDA VIRULENCE
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A  33
ASP A 201
PRO A 131
PHE A 235
TYR A 212
 None
 1.41A 5dlvA-4h43A:
undetectable		 5dlvA-4h43A:
14.93